Experimental and Therapeutic Medicine Article Swipe
· 2025
· Open Access
· DOI: https://doi.org/10.3892/etm
Cancer cachexia occurs in the majority of cancer patients before death, and it is responsible for the death of 22% of cancer patients.One of the most relevant characteristics of cachexia is that of asthenia, which reflects significant muscle wasting noted in cachectic cancer patients The aim of the present study was to assess whether the β 2 -adrenergic agonist formoterol is associated with an improvement in physiological parameters such as grip force and total physical activity in cachetic rats.Administration of the β 2 -agonist formoterol (0.3 mg/kg for 7 days) in rats bearing Yoshida AH-130 ascites hepatoma tumors, a model which induces a strong loss of both body and muscle weight, resulted in a significant reversal of the muscle wasting process, as reflected by individual muscle weights.The anti-wasting effects of the drug were also observed in terms of total physical activity and grip force, thus resulting in an improvement in physical performance in cachectic tumor-bearing rats.
Related Topics
Concepts
Cachexia
Wasting
Molecular medicine
Cancer
Medicine
Agonist
Formoterol
Internal medicine
Cancer cachexia
Anorexia
Lean body mass
Endocrinology
Weight loss
Body weight
Obesity
Receptor
Cell cycle
Corticosteroid
Budesonide
Metadata
- Type
- paratext
- Language
- en
- Landing Page
- https://doi.org/10.3892/etm
- OA Status
- diamond
- Cited By
- 1739
- References
- 25
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4200519416
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4200519416Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3892/etmDigital Object Identifier
- Title
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Experimental and Therapeutic MedicineWork title
- Type
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paratextOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-12-05Full publication date if available
- Landing page
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https://doi.org/10.3892/etmPublisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
diamondOpen access status per OpenAlex
- OA URL
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https://doi.org/10.3892/etmDirect OA link when available
- Concepts
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Cachexia, Wasting, Molecular medicine, Cancer, Medicine, Agonist, Formoterol, Internal medicine, Cancer cachexia, Anorexia, Lean body mass, Endocrinology, Weight loss, Body weight, Obesity, Receptor, Cell cycle, Corticosteroid, BudesonideTop concepts (fields/topics) attached by OpenAlex
- Cited by
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1739Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 68, 2024: 232, 2023: 313, 2022: 269, 2021: 295Per-year citation counts (last 5 years)
- References (count)
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25Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.reflected | 122 |
| abstract_inverted_index.resulting | 145 |
| abstract_inverted_index.associated | 61 |
| abstract_inverted_index.formoterol | 59, 84 |
| abstract_inverted_index.individual | 124 |
| abstract_inverted_index.parameters | 67 |
| abstract_inverted_index.-adrenergic | 57 |
| abstract_inverted_index.improvement | 64, 148 |
| abstract_inverted_index.performance | 151 |
| abstract_inverted_index.responsible | 14 |
| abstract_inverted_index.significant | 36, 114 |
| abstract_inverted_index.weights.The | 126 |
| abstract_inverted_index.anti-wasting | 127 |
| abstract_inverted_index.patients.One | 22 |
| abstract_inverted_index.physiological | 66 |
| abstract_inverted_index.tumor-bearing | 154 |
| abstract_inverted_index.characteristics | 27 |
| abstract_inverted_index.rats.Administration | 78 |
| cited_by_percentile_year | |
| countries_distinct_count | 0 |
| institutions_distinct_count | 0 |
| citation_normalized_percentile |