Experimental evolution of insect immune memory versus pathogen resistance Article Swipe
Imroze Khan
,
Arun Prakash
,
Deepa Agashe
·
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1098/rspb.2017.1583
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1098/rspb.2017.1583
Under strong pathogen pressure, insects often evolve resistance to infection. Many insects are also protected via immune memory (immune priming), whereby sublethal exposure to a pathogen enhances survival after secondary infection. Theory predicts that immune memory should evolve when the pathogen is highly virulent, or when pathogen exposure is relatively rare. However, there are no empirical tests of these hypotheses, and the adaptive benefits of immune memory relative to direct resistance against a pathogen are poorly understood. To determine the selective pressures and ecological conditions that shape immune evolution, we imposed strong pathogen selection on flour beetle ( Tribolium castaneum ) populations, infecting them with Bacillus thuringiensis (Bt) for 11 generations. Populations injected first with heat-killed and then live Bt evolved high basal resistance against multiple Bt strains. By contrast, populations injected only with a high dose of live Bt evolved a less effective but strain-specific priming response. Control populations injected with heat-killed Bt did not evolve priming; and in the ancestor, priming was effective only against a low Bt dose. Intriguingly, one replicate population first evolved priming and subsequently evolved basal resistance, suggesting the potential for dynamic evolution of different immune strategies. Our work is the first report showing that pathogens can select for rapid modulation of insect priming ability, allowing hosts to evolve divergent immune strategies (generalized resistance versus specific immune memory) with potentially distinct mechanisms.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1098/rspb.2017.1583
- https://royalsocietypublishing.org/doi/pdf/10.1098/rspb.2017.1583
- OA Status
- bronze
- Cited By
- 70
- References
- 43
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2951337779
All OpenAlex metadata
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https://openalex.org/W2951337779Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1098/rspb.2017.1583Digital Object Identifier
- Title
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Experimental evolution of insect immune memory versus pathogen resistanceWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2017Year of publication
- Publication date
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2017-12-13Full publication date if available
- Authors
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Imroze Khan, Arun Prakash, Deepa AgasheList of authors in order
- Landing page
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https://doi.org/10.1098/rspb.2017.1583Publisher landing page
- PDF URL
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https://royalsocietypublishing.org/doi/pdf/10.1098/rspb.2017.1583Direct link to full text PDF
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YesWhether a free full text is available
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bronzeOpen access status per OpenAlex
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https://royalsocietypublishing.org/doi/pdf/10.1098/rspb.2017.1583Direct OA link when available
- Concepts
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Biology, Pathogen, Immune system, Priming (agriculture), Bacillus thuringiensis, Experimental evolution, Population, Immunity, Immunology, Microbiology, Genetics, Gene, Botany, Bacteria, Sociology, Demography, GerminationTop concepts (fields/topics) attached by OpenAlex
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70Total citation count in OpenAlex
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2025: 9, 2024: 4, 2023: 3, 2022: 6, 2021: 34Per-year citation counts (last 5 years)
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43Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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