Experimental microevolution of Trypanosoma cruzi reveals hybridization and clonal mechanisms driving rapid diversification of genome sequence and structure Article Swipe
Gabriel Machado Matos
,
Michael D. Lewis
,
Carlos Talavera‐López
,
Matthew Yeo
,
Edmundo C. Grisard
,
Louisa A. Messenger
,
Michael A. Miles
,
Björn Andersson
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1101/2021.10.24.465605
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1101/2021.10.24.465605
Protozoa and fungi are known to have extraordinarily diverse mechanisms of genetic exchange. However, the presence and epidemiological relevance of genetic exchange in Trypanosoma cruzi , the agent of Chagas disease, has been controversial and debated for many years. Field studies have identified both predominantly clonal and sexually recombining natural populations. Two of six natural T. cruzi lineages (TcV and TcVI) show hybrid mosaicism, using analysis of single-gene locus markers. The formation of hybrid strains in vitro has been achieved and this provides a framework to study the mechanisms and adaptive significance of genetic exchange. Using whole genome sequencing of a set of experimental hybrids strains, we have confirmed that hybrid formation initially results in tetraploid parasites. The hybrid progeny showed novel mutations that were not attributable to either (diploid) parent showing an increase in amino acid changes. In long-term culture, up to 800 generations, there was progressive, gradual erosion of progeny genomes towards triploidy, yet retention of elevated copy number was observed at several core housekeeping loci. Our findings indicate hybrid formation by fusion of diploid T. cruzi , followed by sporadic genome erosion, but with substantial potential for adaptive evolution, as has been described as a genetic feature of other organisms, such as some fungi.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2021.10.24.465605
- https://www.biorxiv.org/content/biorxiv/early/2021/10/24/2021.10.24.465605.full.pdf
- OA Status
- green
- References
- 61
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3211285135
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Raw OpenAlex JSON
- OpenAlex ID
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- DOI
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https://doi.org/10.1101/2021.10.24.465605Digital Object Identifier
- Title
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Experimental microevolution of Trypanosoma cruzi reveals hybridization and clonal mechanisms driving rapid diversification of genome sequence and structureWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
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2021-10-24Full publication date if available
- Authors
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Gabriel Machado Matos, Michael D. Lewis, Carlos Talavera‐López, Matthew Yeo, Edmundo C. Grisard, Louisa A. Messenger, Michael A. Miles, Björn AnderssonList of authors in order
- Landing page
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https://doi.org/10.1101/2021.10.24.465605Publisher landing page
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https://www.biorxiv.org/content/biorxiv/early/2021/10/24/2021.10.24.465605.full.pdfDirect link to full text PDF
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
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https://www.biorxiv.org/content/biorxiv/early/2021/10/24/2021.10.24.465605.full.pdfDirect OA link when available
- Concepts
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Biology, Genetics, Microevolution, Genome, Ploidy, Locus (genetics), Trypanosoma cruzi, Whole genome sequencing, Gene, Hybrid, Population, Parasite hosting, World Wide Web, Computer science, Botany, Sociology, DemographyTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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61Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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