Exploiting trans‐Sulfinylation for the Synthesis of Diverse N‐Alkyl Sulfinamides via Decarboxylative Sulfinamidation Article Swipe

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Jonathan Andrews , Russell G. Woodger , Christopher F. Palmer , Darren L. Poole , Michael C. Willis ·

YOU? · · 2024 · Open Access · · DOI: https://doi.org/10.1002/ange.202407970

Combining simple amines with the bench‐stable sulfinylamine Tr‐NSO allows in situ preparation of reactive alkyl sulfinylamines, which when combined with alkyl radicals generated by photocatalytic decarboxylation, provides N‐alkyl sulfinamides. The reactions are broad in scope and tolerate a wide variety of functional groups on both the acid and amine components. The sulfinamide products are used to prepare a selection of challenging S(VI) products. The method provides a convenient way to use reactive and unstable alkyl sulfinylamines.

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Chemistry

Organic Chemistry

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Alkyl Chemistry Organic chemistry

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Type: article
Language: en
Landing Page: https://doi.org/10.1002/ange.202407970
OA Status: hybrid
Cited By: 1
References: 37
Related Works: 10
OpenAlex ID: https://openalex.org/W4400325594

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DOI: https://doi.org/10.1002/ange.202407970

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Title: Exploiting trans‐Sulfinylation for the Synthesis of Diverse N‐Alkyl Sulfinamides via Decarboxylative Sulfinamidation

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Type: article

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Language: en

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Publication year: 2024

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Publication date: 2024-07-04

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Authors: Jonathan Andrews, Russell G. Woodger, Christopher F. Palmer, Darren L. Poole, Michael C. Willis

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Landing page: https://doi.org/10.1002/ange.202407970

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OA URL: https://doi.org/10.1002/ange.202407970

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Concepts: Alkyl, Chemistry, Organic chemistry

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Cited by: 1

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