Exploration of the Antimicrobial Effects of Benzothiazolylthiazolidin-4-One and In Silico Mechanistic Investigation Article Swipe
Michelyne Haroun
,
Christophe Tratrat
,
Anthi Petrou
,
Athina Geronikaki
,
Marija Ivanov
,
Ana Ćirić
,
Marina Sokóvić
,
Nagaraja Sreeharsha
,
Katharigatta N. Venugopala
,
Anroop B. Nair
,
Heba S. Elsewedy
,
Hafedh Kochkar
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/molecules26134061
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/molecules26134061
Background: Infectious diseases still affect large populations causing significant morbidity and mortality. Bacterial and fungal infections for centuries were the main factors of death and disability of millions of humans. Despite the progress in the control of infectious diseases, the appearance of resistance of microbes to existing drugs creates the need for the development of new effective antimicrobial agents. In an attempt to improve the antibacterial activity of previously synthesized compounds modifications to their structures were performed. Methods: Nineteen thiazolidinone derivatives with 6-Cl, 4-OMe, 6-CN, 6-adamantan, 4-Me, 6-adamantan substituents at benzothiazole ring were synthesized and evaluated against panel of four bacterial strains S. aureus, L. monocytogenes, E. coli and S. typhimirium and three resistant strains MRSA, E. coli and P. aeruginosa in order to improve activity of previously evaluated 6-OCF3-benzothiazole-based thiazolidinones. The evaluation of minimum inhibitory and minimum bactericidal concentration was determined by microdilution method. As reference compounds ampicillin and streptomycin were used. Results: All compounds showed antibacterial activity with MIC in range of 0.12–0.75 mg/mL and MBC at 0.25–>1.00 mg/mL The most active compound among all tested appeared to be compound 18, with MIC at 0.10 mg/mL and MBC at 0.12 mg/mL against P. aeruginosa. as well as against resistant strain P. aeruginosa with MIC at 0.06 mg/mL and MBC at 0.12 mg/mL almost equipotent with streptomycin and better than ampicillin. Docking studies predicted that the inhibition of LD-carboxypeptidase is probably the possible mechanism of antibacterial activity of tested compounds. Conclusion: The best improvement of antibacterial activity after modifications was achieved by replacement of 6-OCF3 substituent in benzothiazole moiety by 6-Cl against S. aureus, MRSA and resistant strain of E. coli by 2.5 folds, while against L. monocytogenes and S. typhimirium from 4 to 5 folds.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/molecules26134061
- https://www.mdpi.com/1420-3049/26/13/4061/pdf?version=1625228905
- OA Status
- gold
- Cited By
- 19
- References
- 66
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3174662174
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3174662174Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/molecules26134061Digital Object Identifier
- Title
-
Exploration of the Antimicrobial Effects of Benzothiazolylthiazolidin-4-One and In Silico Mechanistic InvestigationWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-07-02Full publication date if available
- Authors
-
Michelyne Haroun, Christophe Tratrat, Anthi Petrou, Athina Geronikaki, Marija Ivanov, Ana Ćirić, Marina Sokóvić, Nagaraja Sreeharsha, Katharigatta N. Venugopala, Anroop B. Nair, Heba S. Elsewedy, Hafedh KochkarList of authors in order
- Landing page
-
https://doi.org/10.3390/molecules26134061Publisher landing page
- PDF URL
-
https://www.mdpi.com/1420-3049/26/13/4061/pdf?version=1625228905Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/1420-3049/26/13/4061/pdf?version=1625228905Direct OA link when available
- Concepts
-
In silico, Antimicrobial, Computational biology, Biochemical engineering, Chemistry, Biology, Microbiology, Biochemistry, Engineering, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
19Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 4, 2024: 3, 2023: 5, 2022: 6, 2021: 1Per-year citation counts (last 5 years)
- References (count)
-
66Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W3174662174 |
|---|---|
| doi | https://doi.org/10.3390/molecules26134061 |
| ids.doi | https://doi.org/10.3390/molecules26134061 |
| ids.mag | 3174662174 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/34279400 |
| ids.openalex | https://openalex.org/W3174662174 |
| fwci | 1.99029114 |
| mesh[0].qualifier_ui | Q000138 |
| mesh[0].descriptor_ui | D000890 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | chemical synthesis |
| mesh[0].descriptor_name | Anti-Infective Agents |
| mesh[1].qualifier_ui | Q000494 |
| mesh[1].descriptor_ui | D000890 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | pharmacology |
| mesh[1].descriptor_name | Anti-Infective Agents |
| mesh[2].qualifier_ui | Q000037 |
| mesh[2].descriptor_ui | D001426 |
| mesh[2].is_major_topic | False |
| mesh[2].qualifier_name | antagonists & inhibitors |
| mesh[2].descriptor_name | Bacterial Proteins |
| mesh[3].qualifier_ui | Q000737 |
| mesh[3].descriptor_ui | D001426 |
| mesh[3].is_major_topic | False |
| mesh[3].qualifier_name | chemistry |
| mesh[3].descriptor_name | Bacterial Proteins |
| mesh[4].qualifier_ui | Q000378 |
| mesh[4].descriptor_ui | D001426 |
| mesh[4].is_major_topic | False |
| mesh[4].qualifier_name | metabolism |
| mesh[4].descriptor_name | Bacterial Proteins |
| mesh[5].qualifier_ui | Q000037 |
| mesh[5].descriptor_ui | D002268 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | antagonists & inhibitors |
| mesh[5].descriptor_name | Carboxypeptidases |
| mesh[6].qualifier_ui | Q000737 |
| mesh[6].descriptor_ui | D002268 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | chemistry |
| mesh[6].descriptor_name | Carboxypeptidases |
| mesh[7].qualifier_ui | Q000378 |
| mesh[7].descriptor_ui | D002268 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | metabolism |
| mesh[7].descriptor_name | Carboxypeptidases |
| mesh[8].qualifier_ui | Q000187 |
| mesh[8].descriptor_ui | D008089 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | drug effects |
| mesh[8].descriptor_name | Listeria monocytogenes |
| mesh[9].qualifier_ui | Q000187 |
| mesh[9].descriptor_ui | D055624 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | drug effects |
| mesh[9].descriptor_name | Methicillin-Resistant Staphylococcus aureus |
| mesh[10].qualifier_ui | |
| mesh[10].descriptor_ui | D062105 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | |
| mesh[10].descriptor_name | Molecular Docking Simulation |
| mesh[11].qualifier_ui | Q000138 |
| mesh[11].descriptor_ui | D011480 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | chemical synthesis |
| mesh[11].descriptor_name | Protease Inhibitors |
| mesh[12].qualifier_ui | Q000494 |
| mesh[12].descriptor_ui | D011480 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | pharmacology |
| mesh[12].descriptor_name | Protease Inhibitors |
| mesh[13].qualifier_ui | Q000187 |
| mesh[13].descriptor_ui | D012486 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | drug effects |
| mesh[13].descriptor_name | Salmonella typhimurium |
| mesh[14].qualifier_ui | Q000138 |
| mesh[14].descriptor_ui | D053778 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | chemical synthesis |
| mesh[14].descriptor_name | Thiazolidines |
| mesh[15].qualifier_ui | Q000494 |
| mesh[15].descriptor_ui | D053778 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | pharmacology |
| mesh[15].descriptor_name | Thiazolidines |
| mesh[16].qualifier_ui | Q000138 |
| mesh[16].descriptor_ui | D000890 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | chemical synthesis |
| mesh[16].descriptor_name | Anti-Infective Agents |
| mesh[17].qualifier_ui | Q000494 |
| mesh[17].descriptor_ui | D000890 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | pharmacology |
| mesh[17].descriptor_name | Anti-Infective Agents |
| mesh[18].qualifier_ui | Q000037 |
| mesh[18].descriptor_ui | D001426 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | antagonists & inhibitors |
| mesh[18].descriptor_name | Bacterial Proteins |
| mesh[19].qualifier_ui | Q000737 |
| mesh[19].descriptor_ui | D001426 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | chemistry |
| mesh[19].descriptor_name | Bacterial Proteins |
| mesh[20].qualifier_ui | Q000378 |
| mesh[20].descriptor_ui | D001426 |
| mesh[20].is_major_topic | False |
| mesh[20].qualifier_name | metabolism |
| mesh[20].descriptor_name | Bacterial Proteins |
| mesh[21].qualifier_ui | Q000037 |
| mesh[21].descriptor_ui | D002268 |
| mesh[21].is_major_topic | False |
| mesh[21].qualifier_name | antagonists & inhibitors |
| mesh[21].descriptor_name | Carboxypeptidases |
| mesh[22].qualifier_ui | Q000737 |
| mesh[22].descriptor_ui | D002268 |
| mesh[22].is_major_topic | False |
| mesh[22].qualifier_name | chemistry |
| mesh[22].descriptor_name | Carboxypeptidases |
| mesh[23].qualifier_ui | Q000378 |
| mesh[23].descriptor_ui | D002268 |
| mesh[23].is_major_topic | False |
| mesh[23].qualifier_name | metabolism |
| mesh[23].descriptor_name | Carboxypeptidases |
| mesh[24].qualifier_ui | Q000187 |
| mesh[24].descriptor_ui | D008089 |
| mesh[24].is_major_topic | False |
| mesh[24].qualifier_name | drug effects |
| mesh[24].descriptor_name | Listeria monocytogenes |
| mesh[25].qualifier_ui | Q000187 |
| mesh[25].descriptor_ui | D055624 |
| mesh[25].is_major_topic | False |
| mesh[25].qualifier_name | drug effects |
| mesh[25].descriptor_name | Methicillin-Resistant Staphylococcus aureus |
| mesh[26].qualifier_ui | |
| mesh[26].descriptor_ui | D062105 |
| mesh[26].is_major_topic | False |
| mesh[26].qualifier_name | |
| mesh[26].descriptor_name | Molecular Docking Simulation |
| mesh[27].qualifier_ui | Q000138 |
| mesh[27].descriptor_ui | D011480 |
| mesh[27].is_major_topic | False |
| mesh[27].qualifier_name | chemical synthesis |
| mesh[27].descriptor_name | Protease Inhibitors |
| mesh[28].qualifier_ui | Q000494 |
| mesh[28].descriptor_ui | D011480 |
| mesh[28].is_major_topic | False |
| mesh[28].qualifier_name | pharmacology |
| mesh[28].descriptor_name | Protease Inhibitors |
| mesh[29].qualifier_ui | Q000187 |
| mesh[29].descriptor_ui | D012486 |
| mesh[29].is_major_topic | False |
| mesh[29].qualifier_name | drug effects |
| mesh[29].descriptor_name | Salmonella typhimurium |
| mesh[30].qualifier_ui | Q000138 |
| mesh[30].descriptor_ui | D053778 |
| mesh[30].is_major_topic | False |
| mesh[30].qualifier_name | chemical synthesis |
| mesh[30].descriptor_name | Thiazolidines |
| mesh[31].qualifier_ui | Q000494 |
| mesh[31].descriptor_ui | D053778 |
| mesh[31].is_major_topic | False |
| mesh[31].qualifier_name | pharmacology |
| mesh[31].descriptor_name | Thiazolidines |
| mesh[32].qualifier_ui | Q000138 |
| mesh[32].descriptor_ui | D000890 |
| mesh[32].is_major_topic | False |
| mesh[32].qualifier_name | chemical synthesis |
| mesh[32].descriptor_name | Anti-Infective Agents |
| mesh[33].qualifier_ui | Q000494 |
| mesh[33].descriptor_ui | D000890 |
| mesh[33].is_major_topic | False |
| mesh[33].qualifier_name | pharmacology |
| mesh[33].descriptor_name | Anti-Infective Agents |
| mesh[34].qualifier_ui | Q000037 |
| mesh[34].descriptor_ui | D001426 |
| mesh[34].is_major_topic | False |
| mesh[34].qualifier_name | antagonists & inhibitors |
| mesh[34].descriptor_name | Bacterial Proteins |
| mesh[35].qualifier_ui | Q000737 |
| mesh[35].descriptor_ui | D001426 |
| mesh[35].is_major_topic | False |
| mesh[35].qualifier_name | chemistry |
| mesh[35].descriptor_name | Bacterial Proteins |
| mesh[36].qualifier_ui | Q000378 |
| mesh[36].descriptor_ui | D001426 |
| mesh[36].is_major_topic | False |
| mesh[36].qualifier_name | metabolism |
| mesh[36].descriptor_name | Bacterial Proteins |
| mesh[37].qualifier_ui | Q000037 |
| mesh[37].descriptor_ui | D002268 |
| mesh[37].is_major_topic | False |
| mesh[37].qualifier_name | antagonists & inhibitors |
| mesh[37].descriptor_name | Carboxypeptidases |
| mesh[38].qualifier_ui | Q000737 |
| mesh[38].descriptor_ui | D002268 |
| mesh[38].is_major_topic | False |
| mesh[38].qualifier_name | chemistry |
| mesh[38].descriptor_name | Carboxypeptidases |
| mesh[39].qualifier_ui | Q000378 |
| mesh[39].descriptor_ui | D002268 |
| mesh[39].is_major_topic | False |
| mesh[39].qualifier_name | metabolism |
| mesh[39].descriptor_name | Carboxypeptidases |
| mesh[40].qualifier_ui | Q000187 |
| mesh[40].descriptor_ui | D008089 |
| mesh[40].is_major_topic | False |
| mesh[40].qualifier_name | drug effects |
| mesh[40].descriptor_name | Listeria monocytogenes |
| mesh[41].qualifier_ui | Q000187 |
| mesh[41].descriptor_ui | D055624 |
| mesh[41].is_major_topic | False |
| mesh[41].qualifier_name | drug effects |
| mesh[41].descriptor_name | Methicillin-Resistant Staphylococcus aureus |
| mesh[42].qualifier_ui | |
| mesh[42].descriptor_ui | D062105 |
| mesh[42].is_major_topic | False |
| mesh[42].qualifier_name | |
| mesh[42].descriptor_name | Molecular Docking Simulation |
| mesh[43].qualifier_ui | Q000138 |
| mesh[43].descriptor_ui | D011480 |
| mesh[43].is_major_topic | False |
| mesh[43].qualifier_name | chemical synthesis |
| mesh[43].descriptor_name | Protease Inhibitors |
| mesh[44].qualifier_ui | Q000494 |
| mesh[44].descriptor_ui | D011480 |
| mesh[44].is_major_topic | False |
| mesh[44].qualifier_name | pharmacology |
| mesh[44].descriptor_name | Protease Inhibitors |
| mesh[45].qualifier_ui | Q000187 |
| mesh[45].descriptor_ui | D012486 |
| mesh[45].is_major_topic | False |
| mesh[45].qualifier_name | drug effects |
| mesh[45].descriptor_name | Salmonella typhimurium |
| mesh[46].qualifier_ui | Q000138 |
| mesh[46].descriptor_ui | D053778 |
| mesh[46].is_major_topic | False |
| mesh[46].qualifier_name | chemical synthesis |
| mesh[46].descriptor_name | Thiazolidines |
| mesh[47].qualifier_ui | Q000494 |
| mesh[47].descriptor_ui | D053778 |
| mesh[47].is_major_topic | False |
| mesh[47].qualifier_name | pharmacology |
| mesh[47].descriptor_name | Thiazolidines |
| type | article |
| title | Exploration of the Antimicrobial Effects of Benzothiazolylthiazolidin-4-One and In Silico Mechanistic Investigation |
| biblio.issue | 13 |
| biblio.volume | 26 |
| biblio.last_page | 4061 |
| biblio.first_page | 4061 |
| topics[0].id | https://openalex.org/T10274 |
| topics[0].field.id | https://openalex.org/fields/16 |
| topics[0].field.display_name | Chemistry |
| topics[0].score | 0.9997000098228455 |
| topics[0].domain.id | https://openalex.org/domains/3 |
| topics[0].domain.display_name | Physical Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1605 |
| topics[0].subfield.display_name | Organic Chemistry |
| topics[0].display_name | Synthesis and biological activity |
| topics[1].id | https://openalex.org/T10211 |
| topics[1].field.id | https://openalex.org/fields/17 |
| topics[1].field.display_name | Computer Science |
| topics[1].score | 0.9976000189781189 |
| topics[1].domain.id | https://openalex.org/domains/3 |
| topics[1].domain.display_name | Physical Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1703 |
| topics[1].subfield.display_name | Computational Theory and Mathematics |
| topics[1].display_name | Computational Drug Discovery Methods |
| topics[2].id | https://openalex.org/T14099 |
| topics[2].field.id | https://openalex.org/fields/16 |
| topics[2].field.display_name | Chemistry |
| topics[2].score | 0.9957000017166138 |
| topics[2].domain.id | https://openalex.org/domains/3 |
| topics[2].domain.display_name | Physical Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/1605 |
| topics[2].subfield.display_name | Organic Chemistry |
| topics[2].display_name | Synthesis and Characterization of Heterocyclic Compounds |
| is_xpac | False |
| apc_list.value | 2300 |
| apc_list.currency | CHF |
| apc_list.value_usd | 2490 |
| apc_paid.value | 2300 |
| apc_paid.currency | CHF |
| apc_paid.value_usd | 2490 |
| concepts[0].id | https://openalex.org/C2775905019 |
| concepts[0].level | 3 |
| concepts[0].score | 0.8828017711639404 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q192572 |
| concepts[0].display_name | In silico |
| concepts[1].id | https://openalex.org/C4937899 |
| concepts[1].level | 2 |
| concepts[1].score | 0.6508132219314575 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q68541106 |
| concepts[1].display_name | Antimicrobial |
| concepts[2].id | https://openalex.org/C70721500 |
| concepts[2].level | 1 |
| concepts[2].score | 0.6103849411010742 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q177005 |
| concepts[2].display_name | Computational biology |
| concepts[3].id | https://openalex.org/C183696295 |
| concepts[3].level | 1 |
| concepts[3].score | 0.45617955923080444 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q2487696 |
| concepts[3].display_name | Biochemical engineering |
| concepts[4].id | https://openalex.org/C185592680 |
| concepts[4].level | 0 |
| concepts[4].score | 0.3910893201828003 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[4].display_name | Chemistry |
| concepts[5].id | https://openalex.org/C86803240 |
| concepts[5].level | 0 |
| concepts[5].score | 0.35853245854377747 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[5].display_name | Biology |
| concepts[6].id | https://openalex.org/C89423630 |
| concepts[6].level | 1 |
| concepts[6].score | 0.2547993063926697 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q7193 |
| concepts[6].display_name | Microbiology |
| concepts[7].id | https://openalex.org/C55493867 |
| concepts[7].level | 1 |
| concepts[7].score | 0.16722866892814636 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[7].display_name | Biochemistry |
| concepts[8].id | https://openalex.org/C127413603 |
| concepts[8].level | 0 |
| concepts[8].score | 0.1284230351448059 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q11023 |
| concepts[8].display_name | Engineering |
| concepts[9].id | https://openalex.org/C104317684 |
| concepts[9].level | 2 |
| concepts[9].score | 0.0 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q7187 |
| concepts[9].display_name | Gene |
| keywords[0].id | https://openalex.org/keywords/in-silico |
| keywords[0].score | 0.8828017711639404 |
| keywords[0].display_name | In silico |
| keywords[1].id | https://openalex.org/keywords/antimicrobial |
| keywords[1].score | 0.6508132219314575 |
| keywords[1].display_name | Antimicrobial |
| keywords[2].id | https://openalex.org/keywords/computational-biology |
| keywords[2].score | 0.6103849411010742 |
| keywords[2].display_name | Computational biology |
| keywords[3].id | https://openalex.org/keywords/biochemical-engineering |
| keywords[3].score | 0.45617955923080444 |
| keywords[3].display_name | Biochemical engineering |
| keywords[4].id | https://openalex.org/keywords/chemistry |
| keywords[4].score | 0.3910893201828003 |
| keywords[4].display_name | Chemistry |
| keywords[5].id | https://openalex.org/keywords/biology |
| keywords[5].score | 0.35853245854377747 |
| keywords[5].display_name | Biology |
| keywords[6].id | https://openalex.org/keywords/microbiology |
| keywords[6].score | 0.2547993063926697 |
| keywords[6].display_name | Microbiology |
| keywords[7].id | https://openalex.org/keywords/biochemistry |
| keywords[7].score | 0.16722866892814636 |
| keywords[7].display_name | Biochemistry |
| keywords[8].id | https://openalex.org/keywords/engineering |
| keywords[8].score | 0.1284230351448059 |
| keywords[8].display_name | Engineering |
| language | en |
| locations[0].id | doi:10.3390/molecules26134061 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S108911230 |
| locations[0].source.issn | 1420-3049, 1433-1373 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 1420-3049 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Molecules |
| locations[0].source.host_organization | https://openalex.org/P4310310987 |
| locations[0].source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310310987 |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://www.mdpi.com/1420-3049/26/13/4061/pdf?version=1625228905 |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Molecules |
| locations[0].landing_page_url | https://doi.org/10.3390/molecules26134061 |
| locations[1].id | pmid:34279400 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Molecules (Basel, Switzerland) |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/34279400 |
| locations[2].id | pmh:oai:pubmedcentral.nih.gov:8271899 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S2764455111 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed Central |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | other-oa |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | https://openalex.org/licenses/other-oa |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Molecules |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/8271899 |
| locations[3].id | pmh:oai:mdpi.com:/1420-3049/26/13/4061/ |
| locations[3].is_oa | True |
| locations[3].source.id | https://openalex.org/S4306400947 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | True |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | MDPI (MDPI AG) |
| locations[3].source.host_organization | https://openalex.org/I4210097602 |
| locations[3].source.host_organization_name | Multidisciplinary Digital Publishing Institute (Switzerland) |
| locations[3].source.host_organization_lineage | https://openalex.org/I4210097602 |
| locations[3].license | cc-by |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | Text |
| locations[3].license_id | https://openalex.org/licenses/cc-by |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | Molecules; Volume 26; Issue 13; Pages: 4061 |
| locations[3].landing_page_url | https://dx.doi.org/10.3390/molecules26134061 |
| locations[4].id | pmh:oai:doaj.org/article:0f62d5fd50d4408dbcf8ec1b77089a30 |
| locations[4].is_oa | True |
| locations[4].source.id | https://openalex.org/S4306401280 |
| locations[4].source.issn | |
| locations[4].source.type | repository |
| locations[4].source.is_oa | False |
| locations[4].source.issn_l | |
| locations[4].source.is_core | False |
| locations[4].source.is_in_doaj | False |
| locations[4].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[4].source.host_organization | |
| locations[4].source.host_organization_name | |
| locations[4].source.host_organization_lineage | |
| locations[4].license | cc-by-sa |
| locations[4].pdf_url | |
| locations[4].version | submittedVersion |
| locations[4].raw_type | article |
| locations[4].license_id | https://openalex.org/licenses/cc-by-sa |
| locations[4].is_accepted | False |
| locations[4].is_published | False |
| locations[4].raw_source_name | Molecules, Vol 26, Iss 13, p 4061 (2021) |
| locations[4].landing_page_url | https://doaj.org/article/0f62d5fd50d4408dbcf8ec1b77089a30 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5088211625 |
| authorships[0].author.orcid | https://orcid.org/0000-0003-1521-1399 |
| authorships[0].author.display_name | Michelyne Haroun |
| authorships[0].countries | SA |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I4626487 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi Arabia |
| authorships[0].institutions[0].id | https://openalex.org/I4626487 |
| authorships[0].institutions[0].ror | https://ror.org/00dn43547 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I4626487 |
| authorships[0].institutions[0].country_code | SA |
| authorships[0].institutions[0].display_name | King Faisal University |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Michelyne Haroun |
| authorships[0].is_corresponding | True |
| authorships[0].raw_affiliation_strings | Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi Arabia |
| authorships[1].author.id | https://openalex.org/A5061770993 |
| authorships[1].author.orcid | https://orcid.org/0000-0001-9064-1706 |
| authorships[1].author.display_name | Christophe Tratrat |
| authorships[1].countries | SA |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I4626487 |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi Arabia |
| authorships[1].institutions[0].id | https://openalex.org/I4626487 |
| authorships[1].institutions[0].ror | https://ror.org/00dn43547 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I4626487 |
| authorships[1].institutions[0].country_code | SA |
| authorships[1].institutions[0].display_name | King Faisal University |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Christophe Tratrat |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi Arabia |
| authorships[2].author.id | https://openalex.org/A5086912125 |
| authorships[2].author.orcid | https://orcid.org/0000-0001-8587-2710 |
| authorships[2].author.display_name | Anthi Petrou |
| authorships[2].countries | GR |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I21370196 |
| authorships[2].affiliations[0].raw_affiliation_string | School of Pharmacy, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece |
| authorships[2].institutions[0].id | https://openalex.org/I21370196 |
| authorships[2].institutions[0].ror | https://ror.org/02j61yw88 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I21370196 |
| authorships[2].institutions[0].country_code | GR |
| authorships[2].institutions[0].display_name | Aristotle University of Thessaloniki |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Anthi Petrou |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | School of Pharmacy, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece |
| authorships[3].author.id | https://openalex.org/A5041216662 |
| authorships[3].author.orcid | https://orcid.org/0000-0001-9894-7777 |
| authorships[3].author.display_name | Athina Geronikaki |
| authorships[3].countries | GR |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I21370196 |
| authorships[3].affiliations[0].raw_affiliation_string | School of Pharmacy, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece |
| authorships[3].institutions[0].id | https://openalex.org/I21370196 |
| authorships[3].institutions[0].ror | https://ror.org/02j61yw88 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I21370196 |
| authorships[3].institutions[0].country_code | GR |
| authorships[3].institutions[0].display_name | Aristotle University of Thessaloniki |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Athina Geronikaki |
| authorships[3].is_corresponding | True |
| authorships[3].raw_affiliation_strings | School of Pharmacy, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece |
| authorships[4].author.id | https://openalex.org/A5040517622 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-2480-5490 |
| authorships[4].author.display_name | Marija Ivanov |
| authorships[4].countries | RS |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I4068193 |
| authorships[4].affiliations[0].raw_affiliation_string | Mycological Laboratory, Department of Plant Physiology, Institute for Biological Research, Siniša Stanković-National Institute of Republic of Serbia, University of Belgrade, Bulevar Despota Stefana 142, 11000 Belgrade, Serbia |
| authorships[4].institutions[0].id | https://openalex.org/I4068193 |
| authorships[4].institutions[0].ror | https://ror.org/02qsmb048 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I4068193 |
| authorships[4].institutions[0].country_code | RS |
| authorships[4].institutions[0].display_name | University of Belgrade |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Marija Ivanov |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Mycological Laboratory, Department of Plant Physiology, Institute for Biological Research, Siniša Stanković-National Institute of Republic of Serbia, University of Belgrade, Bulevar Despota Stefana 142, 11000 Belgrade, Serbia |
| authorships[5].author.id | https://openalex.org/A5023003388 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-9478-5448 |
| authorships[5].author.display_name | Ana Ćirić |
| authorships[5].countries | RS |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I4068193 |
| authorships[5].affiliations[0].raw_affiliation_string | Mycological Laboratory, Department of Plant Physiology, Institute for Biological Research, Siniša Stanković-National Institute of Republic of Serbia, University of Belgrade, Bulevar Despota Stefana 142, 11000 Belgrade, Serbia |
| authorships[5].institutions[0].id | https://openalex.org/I4068193 |
| authorships[5].institutions[0].ror | https://ror.org/02qsmb048 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I4068193 |
| authorships[5].institutions[0].country_code | RS |
| authorships[5].institutions[0].display_name | University of Belgrade |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Ana Ćirić |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Mycological Laboratory, Department of Plant Physiology, Institute for Biological Research, Siniša Stanković-National Institute of Republic of Serbia, University of Belgrade, Bulevar Despota Stefana 142, 11000 Belgrade, Serbia |
| authorships[6].author.id | https://openalex.org/A5033981454 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-7381-756X |
| authorships[6].author.display_name | Marina Sokóvić |
| authorships[6].countries | RS |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I4068193 |
| authorships[6].affiliations[0].raw_affiliation_string | Mycological Laboratory, Department of Plant Physiology, Institute for Biological Research, Siniša Stanković-National Institute of Republic of Serbia, University of Belgrade, Bulevar Despota Stefana 142, 11000 Belgrade, Serbia |
| authorships[6].institutions[0].id | https://openalex.org/I4068193 |
| authorships[6].institutions[0].ror | https://ror.org/02qsmb048 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I4068193 |
| authorships[6].institutions[0].country_code | RS |
| authorships[6].institutions[0].display_name | University of Belgrade |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Marina Soković |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Mycological Laboratory, Department of Plant Physiology, Institute for Biological Research, Siniša Stanković-National Institute of Republic of Serbia, University of Belgrade, Bulevar Despota Stefana 142, 11000 Belgrade, Serbia |
| authorships[7].author.id | https://openalex.org/A5040297048 |
| authorships[7].author.orcid | https://orcid.org/0000-0002-2058-255X |
| authorships[7].author.display_name | Nagaraja Sreeharsha |
| authorships[7].countries | SA |
| authorships[7].affiliations[0].raw_affiliation_string | Department of Pharmaceutics, Vidya Siri College of Pharmacy, Off Sarjapura Road, Bengaluru 560 035, Karnataka, India |
| authorships[7].affiliations[1].institution_ids | https://openalex.org/I4626487 |
| authorships[7].affiliations[1].raw_affiliation_string | Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi Arabia |
| authorships[7].institutions[0].id | https://openalex.org/I4626487 |
| authorships[7].institutions[0].ror | https://ror.org/00dn43547 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I4626487 |
| authorships[7].institutions[0].country_code | SA |
| authorships[7].institutions[0].display_name | King Faisal University |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Sreeharsha Nagaraja |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi Arabia, Department of Pharmaceutics, Vidya Siri College of Pharmacy, Off Sarjapura Road, Bengaluru 560 035, Karnataka, India |
| authorships[8].author.id | https://openalex.org/A5011098931 |
| authorships[8].author.orcid | https://orcid.org/0000-0003-0680-1549 |
| authorships[8].author.display_name | Katharigatta N. Venugopala |
| authorships[8].countries | SA, ZA |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I177181097 |
| authorships[8].affiliations[0].raw_affiliation_string | Department of Biotechnology and Food Technology, Faculty of Applied Sciences, Durban University of Technology, Durban 4001, South Africa |
| authorships[8].affiliations[1].institution_ids | https://openalex.org/I4626487 |
| authorships[8].affiliations[1].raw_affiliation_string | Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi Arabia |
| authorships[8].institutions[0].id | https://openalex.org/I4626487 |
| authorships[8].institutions[0].ror | https://ror.org/00dn43547 |
| authorships[8].institutions[0].type | education |
| authorships[8].institutions[0].lineage | https://openalex.org/I4626487 |
| authorships[8].institutions[0].country_code | SA |
| authorships[8].institutions[0].display_name | King Faisal University |
| authorships[8].institutions[1].id | https://openalex.org/I177181097 |
| authorships[8].institutions[1].ror | https://ror.org/0303y7a51 |
| authorships[8].institutions[1].type | education |
| authorships[8].institutions[1].lineage | https://openalex.org/I177181097 |
| authorships[8].institutions[1].country_code | ZA |
| authorships[8].institutions[1].display_name | Durban University of Technology |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Katharigatta Narayanaswamy Venugopala |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Department of Biotechnology and Food Technology, Faculty of Applied Sciences, Durban University of Technology, Durban 4001, South Africa, Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi Arabia |
| authorships[9].author.id | https://openalex.org/A5001934184 |
| authorships[9].author.orcid | https://orcid.org/0000-0003-2850-8669 |
| authorships[9].author.display_name | Anroop B. Nair |
| authorships[9].countries | SA |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I4626487 |
| authorships[9].affiliations[0].raw_affiliation_string | Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi Arabia |
| authorships[9].institutions[0].id | https://openalex.org/I4626487 |
| authorships[9].institutions[0].ror | https://ror.org/00dn43547 |
| authorships[9].institutions[0].type | education |
| authorships[9].institutions[0].lineage | https://openalex.org/I4626487 |
| authorships[9].institutions[0].country_code | SA |
| authorships[9].institutions[0].display_name | King Faisal University |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Anroop Balachandran Nair |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi Arabia |
| authorships[10].author.id | https://openalex.org/A5088799187 |
| authorships[10].author.orcid | https://orcid.org/0000-0002-3221-9168 |
| authorships[10].author.display_name | Heba S. Elsewedy |
| authorships[10].countries | SA |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I4626487 |
| authorships[10].affiliations[0].raw_affiliation_string | Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi Arabia |
| authorships[10].institutions[0].id | https://openalex.org/I4626487 |
| authorships[10].institutions[0].ror | https://ror.org/00dn43547 |
| authorships[10].institutions[0].type | education |
| authorships[10].institutions[0].lineage | https://openalex.org/I4626487 |
| authorships[10].institutions[0].country_code | SA |
| authorships[10].institutions[0].display_name | King Faisal University |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Heba S. Elsewedy |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi Arabia |
| authorships[11].author.id | https://openalex.org/A5084125508 |
| authorships[11].author.orcid | https://orcid.org/0000-0002-8176-6571 |
| authorships[11].author.display_name | Hafedh Kochkar |
| authorships[11].countries | SA |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I76571253 |
| authorships[11].affiliations[0].raw_affiliation_string | Basic & Applied Scientific Research Center, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia |
| authorships[11].affiliations[1].institution_ids | https://openalex.org/I76571253 |
| authorships[11].affiliations[1].raw_affiliation_string | Department of Chemistry, College of Science, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia |
| authorships[11].institutions[0].id | https://openalex.org/I76571253 |
| authorships[11].institutions[0].ror | https://ror.org/038cy8j79 |
| authorships[11].institutions[0].type | education |
| authorships[11].institutions[0].lineage | https://openalex.org/I76571253 |
| authorships[11].institutions[0].country_code | SA |
| authorships[11].institutions[0].display_name | Imam Abdulrahman Bin Faisal University |
| authorships[11].author_position | last |
| authorships[11].raw_author_name | Hafedh Kochkar |
| authorships[11].is_corresponding | False |
| authorships[11].raw_affiliation_strings | Basic & Applied Scientific Research Center, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia, Department of Chemistry, College of Science, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.mdpi.com/1420-3049/26/13/4061/pdf?version=1625228905 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Exploration of the Antimicrobial Effects of Benzothiazolylthiazolidin-4-One and In Silico Mechanistic Investigation |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10274 |
| primary_topic.field.id | https://openalex.org/fields/16 |
| primary_topic.field.display_name | Chemistry |
| primary_topic.score | 0.9997000098228455 |
| primary_topic.domain.id | https://openalex.org/domains/3 |
| primary_topic.domain.display_name | Physical Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1605 |
| primary_topic.subfield.display_name | Organic Chemistry |
| primary_topic.display_name | Synthesis and biological activity |
| related_works | https://openalex.org/W2003194288, https://openalex.org/W2513589746, https://openalex.org/W2153919606, https://openalex.org/W2213189664, https://openalex.org/W2074002899, https://openalex.org/W2062254828, https://openalex.org/W4237480606, https://openalex.org/W2936968863, https://openalex.org/W2941821699, https://openalex.org/W1971792277 |
| cited_by_count | 19 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 4 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 3 |
| counts_by_year[2].year | 2023 |
| counts_by_year[2].cited_by_count | 5 |
| counts_by_year[3].year | 2022 |
| counts_by_year[3].cited_by_count | 6 |
| counts_by_year[4].year | 2021 |
| counts_by_year[4].cited_by_count | 1 |
| locations_count | 5 |
| best_oa_location.id | doi:10.3390/molecules26134061 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S108911230 |
| best_oa_location.source.issn | 1420-3049, 1433-1373 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 1420-3049 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Molecules |
| best_oa_location.source.host_organization | https://openalex.org/P4310310987 |
| best_oa_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://www.mdpi.com/1420-3049/26/13/4061/pdf?version=1625228905 |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Molecules |
| best_oa_location.landing_page_url | https://doi.org/10.3390/molecules26134061 |
| primary_location.id | doi:10.3390/molecules26134061 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S108911230 |
| primary_location.source.issn | 1420-3049, 1433-1373 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 1420-3049 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Molecules |
| primary_location.source.host_organization | https://openalex.org/P4310310987 |
| primary_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://www.mdpi.com/1420-3049/26/13/4061/pdf?version=1625228905 |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Molecules |
| primary_location.landing_page_url | https://doi.org/10.3390/molecules26134061 |
| publication_date | 2021-07-02 |
| publication_year | 2021 |
| referenced_works | https://openalex.org/W3006198151, https://openalex.org/W2134122507, https://openalex.org/W1989044995, https://openalex.org/W2971842436, https://openalex.org/W1653739410, https://openalex.org/W2783897572, https://openalex.org/W3092712933, https://openalex.org/W2160147788, https://openalex.org/W3091865989, https://openalex.org/W2027991790, https://openalex.org/W3021313895, https://openalex.org/W3113586818, https://openalex.org/W2789495552, https://openalex.org/W3023571643, https://openalex.org/W3003680559, https://openalex.org/W3094337096, https://openalex.org/W2793653487, https://openalex.org/W2014629964, https://openalex.org/W2622625576, https://openalex.org/W6746133347, https://openalex.org/W2992038112, https://openalex.org/W2800353007, https://openalex.org/W3044542086, https://openalex.org/W3102110386, https://openalex.org/W2951438665, https://openalex.org/W3080940645, https://openalex.org/W2946254528, https://openalex.org/W2904265364, https://openalex.org/W2283808938, https://openalex.org/W2177027740, https://openalex.org/W3017677608, https://openalex.org/W1997729148, https://openalex.org/W2286357612, https://openalex.org/W2974144491, https://openalex.org/W2485803280, https://openalex.org/W2013021080, https://openalex.org/W2095300431, https://openalex.org/W3099837439, https://openalex.org/W3088640685, https://openalex.org/W3116350895, https://openalex.org/W3047767410, https://openalex.org/W3046598720, https://openalex.org/W2887011246, https://openalex.org/W3139272602, https://openalex.org/W3107497725, https://openalex.org/W1507102203, https://openalex.org/W1997872815, https://openalex.org/W2135732933, https://openalex.org/W2052907531, https://openalex.org/W2105649494, https://openalex.org/W2011505858, https://openalex.org/W2003076573, https://openalex.org/W1973428197, https://openalex.org/W2033495141, https://openalex.org/W2051216542, https://openalex.org/W2028347256, https://openalex.org/W2124029523, https://openalex.org/W2797251728, https://openalex.org/W2735092774, https://openalex.org/W2981892507, https://openalex.org/W1964366874, https://openalex.org/W2962873827, https://openalex.org/W3082334027, https://openalex.org/W2767586820, https://openalex.org/W1515319064, https://openalex.org/W4249509658 |
| referenced_works_count | 66 |
| abstract_inverted_index.4 | 283 |
| abstract_inverted_index.5 | 285 |
| abstract_inverted_index.As | 145 |
| abstract_inverted_index.E. | 106, 116, 270 |
| abstract_inverted_index.In | 59 |
| abstract_inverted_index.L. | 104, 277 |
| abstract_inverted_index.P. | 119, 194, 202 |
| abstract_inverted_index.S. | 102, 109, 263, 280 |
| abstract_inverted_index.an | 60 |
| abstract_inverted_index.as | 196, 198 |
| abstract_inverted_index.at | 89, 168, 185, 190, 206, 211 |
| abstract_inverted_index.be | 180 |
| abstract_inverted_index.by | 142, 252, 260, 272 |
| abstract_inverted_index.in | 33, 121, 161, 257 |
| abstract_inverted_index.is | 230 |
| abstract_inverted_index.of | 22, 26, 28, 36, 41, 43, 54, 67, 98, 126, 133, 163, 228, 235, 238, 245, 254, 269 |
| abstract_inverted_index.to | 45, 62, 72, 123, 179, 284 |
| abstract_inverted_index.18, | 182 |
| abstract_inverted_index.2.5 | 273 |
| abstract_inverted_index.All | 154 |
| abstract_inverted_index.MBC | 167, 189, 210 |
| abstract_inverted_index.MIC | 160, 184, 205 |
| abstract_inverted_index.The | 131, 171, 242 |
| abstract_inverted_index.all | 176 |
| abstract_inverted_index.and | 10, 13, 24, 94, 108, 111, 118, 136, 149, 166, 188, 209, 218, 266, 279 |
| abstract_inverted_index.for | 16, 51 |
| abstract_inverted_index.new | 55 |
| abstract_inverted_index.the | 19, 31, 34, 39, 49, 52, 64, 226, 232 |
| abstract_inverted_index.was | 140, 250 |
| abstract_inverted_index.0.06 | 207 |
| abstract_inverted_index.0.10 | 186 |
| abstract_inverted_index.0.12 | 191, 212 |
| abstract_inverted_index.6-Cl | 261 |
| abstract_inverted_index.MRSA | 265 |
| abstract_inverted_index.best | 243 |
| abstract_inverted_index.coli | 107, 117, 271 |
| abstract_inverted_index.four | 99 |
| abstract_inverted_index.from | 282 |
| abstract_inverted_index.main | 20 |
| abstract_inverted_index.most | 172 |
| abstract_inverted_index.need | 50 |
| abstract_inverted_index.ring | 91 |
| abstract_inverted_index.than | 220 |
| abstract_inverted_index.that | 225 |
| abstract_inverted_index.well | 197 |
| abstract_inverted_index.were | 18, 75, 92, 151 |
| abstract_inverted_index.with | 81, 159, 183, 204, 216 |
| abstract_inverted_index.4-Me, | 86 |
| abstract_inverted_index.6-CN, | 84 |
| abstract_inverted_index.6-Cl, | 82 |
| abstract_inverted_index.MRSA, | 115 |
| abstract_inverted_index.after | 248 |
| abstract_inverted_index.among | 175 |
| abstract_inverted_index.death | 23 |
| abstract_inverted_index.drugs | 47 |
| abstract_inverted_index.large | 5 |
| abstract_inverted_index.mg/mL | 165, 170, 187, 192, 208, 213 |
| abstract_inverted_index.order | 122 |
| abstract_inverted_index.panel | 97 |
| abstract_inverted_index.range | 162 |
| abstract_inverted_index.still | 3 |
| abstract_inverted_index.their | 73 |
| abstract_inverted_index.three | 112 |
| abstract_inverted_index.used. | 152 |
| abstract_inverted_index.while | 275 |
| abstract_inverted_index.4-OMe, | 83 |
| abstract_inverted_index.6-OCF3 | 255 |
| abstract_inverted_index.active | 173 |
| abstract_inverted_index.affect | 4 |
| abstract_inverted_index.almost | 214 |
| abstract_inverted_index.better | 219 |
| abstract_inverted_index.folds, | 274 |
| abstract_inverted_index.folds. | 286 |
| abstract_inverted_index.fungal | 14 |
| abstract_inverted_index.moiety | 259 |
| abstract_inverted_index.showed | 156 |
| abstract_inverted_index.strain | 201, 268 |
| abstract_inverted_index.tested | 177, 239 |
| abstract_inverted_index.Despite | 30 |
| abstract_inverted_index.Docking | 222 |
| abstract_inverted_index.against | 96, 193, 199, 262, 276 |
| abstract_inverted_index.agents. | 58 |
| abstract_inverted_index.attempt | 61 |
| abstract_inverted_index.aureus, | 103, 264 |
| abstract_inverted_index.causing | 7 |
| abstract_inverted_index.control | 35 |
| abstract_inverted_index.creates | 48 |
| abstract_inverted_index.factors | 21 |
| abstract_inverted_index.humans. | 29 |
| abstract_inverted_index.improve | 63, 124 |
| abstract_inverted_index.method. | 144 |
| abstract_inverted_index.minimum | 134, 137 |
| abstract_inverted_index.strains | 101, 114 |
| abstract_inverted_index.studies | 223 |
| abstract_inverted_index.Methods: | 77 |
| abstract_inverted_index.Nineteen | 78 |
| abstract_inverted_index.Results: | 153 |
| abstract_inverted_index.achieved | 251 |
| abstract_inverted_index.activity | 66, 125, 158, 237, 247 |
| abstract_inverted_index.appeared | 178 |
| abstract_inverted_index.compound | 174, 181 |
| abstract_inverted_index.diseases | 2 |
| abstract_inverted_index.existing | 46 |
| abstract_inverted_index.microbes | 44 |
| abstract_inverted_index.millions | 27 |
| abstract_inverted_index.possible | 233 |
| abstract_inverted_index.probably | 231 |
| abstract_inverted_index.progress | 32 |
| abstract_inverted_index.Bacterial | 12 |
| abstract_inverted_index.bacterial | 100 |
| abstract_inverted_index.centuries | 17 |
| abstract_inverted_index.compounds | 70, 147, 155 |
| abstract_inverted_index.diseases, | 38 |
| abstract_inverted_index.effective | 56 |
| abstract_inverted_index.evaluated | 95, 128 |
| abstract_inverted_index.mechanism | 234 |
| abstract_inverted_index.morbidity | 9 |
| abstract_inverted_index.predicted | 224 |
| abstract_inverted_index.reference | 146 |
| abstract_inverted_index.resistant | 113, 200, 267 |
| abstract_inverted_index.Infectious | 1 |
| abstract_inverted_index.aeruginosa | 120, 203 |
| abstract_inverted_index.ampicillin | 148 |
| abstract_inverted_index.appearance | 40 |
| abstract_inverted_index.compounds. | 240 |
| abstract_inverted_index.determined | 141 |
| abstract_inverted_index.disability | 25 |
| abstract_inverted_index.equipotent | 215 |
| abstract_inverted_index.evaluation | 132 |
| abstract_inverted_index.infections | 15 |
| abstract_inverted_index.infectious | 37 |
| abstract_inverted_index.inhibition | 227 |
| abstract_inverted_index.inhibitory | 135 |
| abstract_inverted_index.mortality. | 11 |
| abstract_inverted_index.performed. | 76 |
| abstract_inverted_index.previously | 68, 127 |
| abstract_inverted_index.resistance | 42 |
| abstract_inverted_index.structures | 74 |
| abstract_inverted_index.0.12–0.75 | 164 |
| abstract_inverted_index.6-adamantan | 87 |
| abstract_inverted_index.Background: | 0 |
| abstract_inverted_index.Conclusion: | 241 |
| abstract_inverted_index.aeruginosa. | 195 |
| abstract_inverted_index.ampicillin. | 221 |
| abstract_inverted_index.derivatives | 80 |
| abstract_inverted_index.development | 53 |
| abstract_inverted_index.improvement | 244 |
| abstract_inverted_index.populations | 6 |
| abstract_inverted_index.replacement | 253 |
| abstract_inverted_index.significant | 8 |
| abstract_inverted_index.substituent | 256 |
| abstract_inverted_index.synthesized | 69, 93 |
| abstract_inverted_index.typhimirium | 110, 281 |
| abstract_inverted_index.6-adamantan, | 85 |
| abstract_inverted_index.bactericidal | 138 |
| abstract_inverted_index.streptomycin | 150, 217 |
| abstract_inverted_index.substituents | 88 |
| abstract_inverted_index.antibacterial | 65, 157, 236, 246 |
| abstract_inverted_index.antimicrobial | 57 |
| abstract_inverted_index.benzothiazole | 90, 258 |
| abstract_inverted_index.concentration | 139 |
| abstract_inverted_index.microdilution | 143 |
| abstract_inverted_index.modifications | 71, 249 |
| abstract_inverted_index.monocytogenes | 278 |
| abstract_inverted_index.monocytogenes, | 105 |
| abstract_inverted_index.thiazolidinone | 79 |
| abstract_inverted_index.0.25–>1.00 | 169 |
| abstract_inverted_index.thiazolidinones. | 130 |
| abstract_inverted_index.LD-carboxypeptidase | 229 |
| abstract_inverted_index.6-OCF3-benzothiazole-based | 129 |
| cited_by_percentile_year.max | 98 |
| cited_by_percentile_year.min | 89 |
| corresponding_author_ids | https://openalex.org/A5041216662, https://openalex.org/A5088211625 |
| countries_distinct_count | 4 |
| institutions_distinct_count | 12 |
| corresponding_institution_ids | https://openalex.org/I21370196, https://openalex.org/I4626487 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8399999737739563 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.82495985 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |