Exploratory rearing is governed by hypothalamic MCH cells according to the locus coeruleus Article Swipe
Cristina Concetti
,
Paulius Viskaitis
,
Nikola Grujic
,
Sian N. Duss
,
Mattia Privitera
,
Johannes Bohacek
,
Daria Peleg‐Raibstein
,
Denis Burdakov
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1101/2023.07.19.549648
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1101/2023.07.19.549648
Exploration is essential for survival because it allows animals to gather information about their environment. Rearing is a classic exploratory behavior, during which an animal transiently stands on its hind legs to sample its environment. It is widely observed in common lab conditions as well as in the wild, yet neural signals and circuits underlying this fundamental component of innate behavior remain unclear. We examined behavioral correlates of activity in hypothalamic MCH-producing neurons (MNs) – a recently characterized but still poorly understood neural type – and found that MN activation co-occurs with exploratory rears in mice. Complementary optogenetic and pharmacological manipulations indicated that MN activity selectively promotes rearing via G-protein coupled MCHR1 receptors. Furthermore, we show in vivo that activation of the locus coeruleus noradrenergic neurons rapidly inhibits MNs and suppresses rearing through MCHR1-dependent pathways. Overall, these findings define a subcortical neural module which both tracks and controls exploratory rearing.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2023.07.19.549648
- https://www.biorxiv.org/content/biorxiv/early/2023/07/19/2023.07.19.549648.full.pdf
- OA Status
- green
- Cited By
- 3
- References
- 95
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4384829995
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4384829995Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2023.07.19.549648Digital Object Identifier
- Title
-
Exploratory rearing is governed by hypothalamic MCH cells according to the locus coeruleusWork title
- Type
-
preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-07-19Full publication date if available
- Authors
-
Cristina Concetti, Paulius Viskaitis, Nikola Grujic, Sian N. Duss, Mattia Privitera, Johannes Bohacek, Daria Peleg‐Raibstein, Denis BurdakovList of authors in order
- Landing page
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https://doi.org/10.1101/2023.07.19.549648Publisher landing page
- PDF URL
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https://www.biorxiv.org/content/biorxiv/early/2023/07/19/2023.07.19.549648.full.pdfDirect link to full text PDF
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YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.biorxiv.org/content/biorxiv/early/2023/07/19/2023.07.19.549648.full.pdfDirect OA link when available
- Concepts
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Locus coeruleus, Optogenetics, Neuroscience, Biological neural network, Biology, Animal behavior, Receptor, Central nervous system, Psychology, Endocrinology, Internal medicine, Medicine, Genetics, ZoologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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3Total citation count in OpenAlex
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2025: 1, 2024: 1, 2023: 1Per-year citation counts (last 5 years)
- References (count)
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95Number of works referenced by this work
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-
10Other works algorithmically related by OpenAlex
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| primary_location.raw_type | posted-content |
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| publication_year | 2023 |
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| abstract_inverted_index.We | 64 |
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| corresponding_institution_ids | https://openalex.org/I35440088 |
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| citation_normalized_percentile.is_in_top_10_percent | False |