Exploring Adverse Outcome Pathways for Nanomaterials with semantic web technologies Article Swipe
Jeaphianne van Rijn
,
Marvin Martens
,
Ammar Ammar
,
Mihaela Roxana Cimpan
,
Valérie Fessard
,
Peter Hoet
,
Nina Jeliazkova
,
Sivakumar Murugadoss
,
Ivana Vinković Vrček
,
Egon Willighagen
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.26434/chemrxiv-2023-kjcl6
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.26434/chemrxiv-2023-kjcl6
Adverse Outcome Pathways (AOPs) have been proposed to facilitate mechanistic understanding of interactions of chemicals/materials with biological systems. Each AOP starts with a molecular initiating event (MIE) and possibly ends with adverse outcome(s) (AOs) via a series of key events (KEs). So far, the interaction of engineered nanomaterials (ENMs) with biomolecules, biomembranes, cells, and biological structures, in general, is not yet fully elucidated yet. There is also a huge lack of information on which AOPs are ENMs-relevant or -specific, despite numerous published data on toxicological endpoints they trigger, such as oxidative stress and inflammation. We propose to integrate related data and knowledge recently collected. Our approach combines the annotation of nanomaterials and their MIEs with ontology annotation to demonstrate how we can then query AOPs and biological pathway information for these materials. We conclude that a FAIR (Findable, Accessible, Interoperable, Reusable) representation of the ENM-MIE knowledge simplifies integration with other knowledge.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.26434/chemrxiv-2023-kjcl6
- https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/649e8f65ba3e99daef490af1/original/exploring-adverse-outcome-pathways-for-nanomaterials-with-semantic-web-technologies.pdf
- OA Status
- gold
- References
- 68
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4382938079
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4382938079Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.26434/chemrxiv-2023-kjcl6Digital Object Identifier
- Title
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Exploring Adverse Outcome Pathways for Nanomaterials with semantic web technologiesWork title
- Type
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preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-07-03Full publication date if available
- Authors
-
Jeaphianne van Rijn, Marvin Martens, Ammar Ammar, Mihaela Roxana Cimpan, Valérie Fessard, Peter Hoet, Nina Jeliazkova, Sivakumar Murugadoss, Ivana Vinković Vrček, Egon WillighagenList of authors in order
- Landing page
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https://doi.org/10.26434/chemrxiv-2023-kjcl6Publisher landing page
- PDF URL
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https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/649e8f65ba3e99daef490af1/original/exploring-adverse-outcome-pathways-for-nanomaterials-with-semantic-web-technologies.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
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https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/649e8f65ba3e99daef490af1/original/exploring-adverse-outcome-pathways-for-nanomaterials-with-semantic-web-technologies.pdfDirect OA link when available
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Adverse Outcome Pathway, Ontology, Computer science, Interoperability, Semantic Web, Representation (politics), Data science, Computational biology, Information retrieval, World Wide Web, Biology, Politics, Epistemology, Philosophy, Political science, LawTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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68Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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