Exploring affinity receptors in bioanalysis: from natural binders to biomimetics Article Swipe
Federico Maria Vivaldi
,
Francesca Torrini
,
Fagnani Francesco
,
Maria Minunni
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1016/j.snr.2025.100359
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1016/j.snr.2025.100359
Affinity receptors have played a pivotal role in advancing bioanalysis, primarily for diagnostic and therapeutic purposes, thanks to their high selectivity toward target molecules, which enables their use in complex biofluids. While antibodies remain the gold standard, ongoing research has explored alternative receptors with improved stability, reduced size, and enhanced performance in bioanalytical and clinical applications. This works traces the evolution of affinity receptors from classical antibodies to emerging biomimetic and synthetic alternatives, including affibodies, nanobodies, aptamers, and molecularly imprinted polymers (MIPs). We highlight their molecular features, advantages, and limitations, emphasizing their use as part of the molecular toolbox for bioanalytical assay development and biosensing. Overall, the continuous diversification of affinity binders reflects the dynamic nature of this field, where the optimal receptor remains context dependent. For this reason, the research into new binders to complement or eventually replace antibodies that, for the moment, remain the choice for high-throughput applications, is still ongoing.
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https://doi.org/10.1016/j.snr.2025.100359Digital Object Identifier
- Title
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Exploring affinity receptors in bioanalysis: from natural binders to biomimeticsWork title
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articleOpenAlex work type
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enPrimary language
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2025Year of publication
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2025-07-03Full publication date if available
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Federico Maria Vivaldi, Francesca Torrini, Fagnani Francesco, Maria MinunniList of authors in order
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https://doi.org/10.1016/j.snr.2025.100359Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.1016/j.snr.2025.100359Direct OA link when available
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0Total citation count in OpenAlex
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155Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.for | 11, 99, 141, 147 |
| abstract_inverted_index.has | 39 |
| abstract_inverted_index.new | 132 |
| abstract_inverted_index.the | 34, 59, 96, 106, 113, 120, 129, 142, 145 |
| abstract_inverted_index.use | 27, 92 |
| abstract_inverted_index.This | 56 |
| abstract_inverted_index.from | 64 |
| abstract_inverted_index.gold | 35 |
| abstract_inverted_index.have | 2 |
| abstract_inverted_index.high | 19 |
| abstract_inverted_index.into | 131 |
| abstract_inverted_index.part | 94 |
| abstract_inverted_index.role | 6 |
| abstract_inverted_index.this | 117, 127 |
| abstract_inverted_index.with | 43 |
| abstract_inverted_index.While | 31 |
| abstract_inverted_index.assay | 101 |
| abstract_inverted_index.size, | 47 |
| abstract_inverted_index.still | 151 |
| abstract_inverted_index.that, | 140 |
| abstract_inverted_index.their | 18, 26, 84, 91 |
| abstract_inverted_index.where | 119 |
| abstract_inverted_index.which | 24 |
| abstract_inverted_index.works | 57 |
| abstract_inverted_index.choice | 146 |
| abstract_inverted_index.field, | 118 |
| abstract_inverted_index.nature | 115 |
| abstract_inverted_index.played | 3 |
| abstract_inverted_index.remain | 33, 144 |
| abstract_inverted_index.target | 22 |
| abstract_inverted_index.thanks | 16 |
| abstract_inverted_index.toward | 21 |
| abstract_inverted_index.traces | 58 |
| abstract_inverted_index.(MIPs). | 81 |
| abstract_inverted_index.binders | 111, 133 |
| abstract_inverted_index.complex | 29 |
| abstract_inverted_index.context | 124 |
| abstract_inverted_index.dynamic | 114 |
| abstract_inverted_index.enables | 25 |
| abstract_inverted_index.moment, | 143 |
| abstract_inverted_index.ongoing | 37 |
| abstract_inverted_index.optimal | 121 |
| abstract_inverted_index.pivotal | 5 |
| abstract_inverted_index.reason, | 128 |
| abstract_inverted_index.reduced | 46 |
| abstract_inverted_index.remains | 123 |
| abstract_inverted_index.replace | 138 |
| abstract_inverted_index.toolbox | 98 |
| abstract_inverted_index.Affinity | 0 |
| abstract_inverted_index.Overall, | 105 |
| abstract_inverted_index.affinity | 62, 110 |
| abstract_inverted_index.clinical | 54 |
| abstract_inverted_index.emerging | 68 |
| abstract_inverted_index.enhanced | 49 |
| abstract_inverted_index.explored | 40 |
| abstract_inverted_index.improved | 44 |
| abstract_inverted_index.ongoing. | 152 |
| abstract_inverted_index.polymers | 80 |
| abstract_inverted_index.receptor | 122 |
| abstract_inverted_index.reflects | 112 |
| abstract_inverted_index.research | 38, 130 |
| abstract_inverted_index.advancing | 8 |
| abstract_inverted_index.aptamers, | 76 |
| abstract_inverted_index.classical | 65 |
| abstract_inverted_index.evolution | 60 |
| abstract_inverted_index.features, | 86 |
| abstract_inverted_index.highlight | 83 |
| abstract_inverted_index.imprinted | 79 |
| abstract_inverted_index.including | 73 |
| abstract_inverted_index.molecular | 85, 97 |
| abstract_inverted_index.primarily | 10 |
| abstract_inverted_index.purposes, | 15 |
| abstract_inverted_index.receptors | 1, 42, 63 |
| abstract_inverted_index.standard, | 36 |
| abstract_inverted_index.synthetic | 71 |
| abstract_inverted_index.antibodies | 32, 66, 139 |
| abstract_inverted_index.biofluids. | 30 |
| abstract_inverted_index.biomimetic | 69 |
| abstract_inverted_index.complement | 135 |
| abstract_inverted_index.continuous | 107 |
| abstract_inverted_index.dependent. | 125 |
| abstract_inverted_index.diagnostic | 12 |
| abstract_inverted_index.eventually | 137 |
| abstract_inverted_index.molecules, | 23 |
| abstract_inverted_index.stability, | 45 |
| abstract_inverted_index.advantages, | 87 |
| abstract_inverted_index.affibodies, | 74 |
| abstract_inverted_index.alternative | 41 |
| abstract_inverted_index.biosensing. | 104 |
| abstract_inverted_index.development | 102 |
| abstract_inverted_index.emphasizing | 90 |
| abstract_inverted_index.molecularly | 78 |
| abstract_inverted_index.nanobodies, | 75 |
| abstract_inverted_index.performance | 50 |
| abstract_inverted_index.selectivity | 20 |
| abstract_inverted_index.therapeutic | 14 |
| abstract_inverted_index.bioanalysis, | 9 |
| abstract_inverted_index.limitations, | 89 |
| abstract_inverted_index.alternatives, | 72 |
| abstract_inverted_index.applications, | 149 |
| abstract_inverted_index.applications. | 55 |
| abstract_inverted_index.bioanalytical | 52, 100 |
| abstract_inverted_index.diversification | 108 |
| abstract_inverted_index.high-throughput | 148 |
| cited_by_percentile_year | |
| countries_distinct_count | 0 |
| institutions_distinct_count | 4 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/2 |
| sustainable_development_goals[0].score | 0.5699999928474426 |
| sustainable_development_goals[0].display_name | Zero hunger |
| citation_normalized_percentile.value | 0.36274574 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |