Exploring cancer metabolism using stable isotope-resolved metabolomics (SIRM) Article Swipe
Ronald C. Bruntz
,
Andrew N. Lane
,
Richard M. Higashi
,
Teresa W.‐M. Fan
·
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1074/jbc.r117.776054
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1074/jbc.r117.776054
Metabolic reprogramming is a hallmark of cancer. The changes in metabolism are adaptive to permit proliferation, survival, and eventually metastasis in a harsh environment. Stable isotope-resolved metabolomics (SIRM) is an approach that uses advanced approaches of NMR and mass spectrometry to analyze the fate of individual atoms from stable isotope-enriched precursors to products to deduce metabolic pathways and networks. The approach can be applied to a wide range of biological systems, including human subjects. This review focuses on the applications of SIRM to cancer metabolism and its use in understanding drug actions.
Related Topics
Concepts
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1074/jbc.r117.776054
- http://www.jbc.org/article/S0021925820370289/pdf
- OA Status
- hybrid
- Cited By
- 97
- References
- 104
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2624447764
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2624447764Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1074/jbc.r117.776054Digital Object Identifier
- Title
-
Exploring cancer metabolism using stable isotope-resolved metabolomics (SIRM)Work title
- Type
-
reviewOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2017Year of publication
- Publication date
-
2017-06-08Full publication date if available
- Authors
-
Ronald C. Bruntz, Andrew N. Lane, Richard M. Higashi, Teresa W.‐M. FanList of authors in order
- Landing page
-
https://doi.org/10.1074/jbc.r117.776054Publisher landing page
- PDF URL
-
https://www.jbc.org/article/S0021925820370289/pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://www.jbc.org/article/S0021925820370289/pdfDirect OA link when available
- Concepts
-
Metabolomics, Chemistry, Stable isotope ratio, Environmental chemistry, Energy metabolism, Metabolism, Computational biology, Biology, Chromatography, Biochemistry, Physics, Quantum mechanics, EndocrinologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
97Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 5, 2024: 9, 2023: 10, 2022: 12, 2021: 16Per-year citation counts (last 5 years)
- References (count)
-
104Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W2624447764 |
|---|---|
| doi | https://doi.org/10.1074/jbc.r117.776054 |
| ids.doi | https://doi.org/10.1074/jbc.r117.776054 |
| ids.mag | 2624447764 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/28592486 |
| ids.openalex | https://openalex.org/W2624447764 |
| fwci | 6.01266193 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D000818 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Animals |
| mesh[1].qualifier_ui | Q000494 |
| mesh[1].descriptor_ui | D000970 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | pharmacology |
| mesh[1].descriptor_name | Antineoplastic Agents |
| mesh[2].qualifier_ui | Q000627 |
| mesh[2].descriptor_ui | D000970 |
| mesh[2].is_major_topic | False |
| mesh[2].qualifier_name | therapeutic use |
| mesh[2].descriptor_name | Antineoplastic Agents |
| mesh[3].qualifier_ui | |
| mesh[3].descriptor_ui | D002247 |
| mesh[3].is_major_topic | False |
| mesh[3].qualifier_name | |
| mesh[3].descriptor_name | Carbon Isotopes |
| mesh[4].qualifier_ui | Q000187 |
| mesh[4].descriptor_ui | D065150 |
| mesh[4].is_major_topic | False |
| mesh[4].qualifier_name | drug effects |
| mesh[4].descriptor_name | Cellular Reprogramming |
| mesh[5].qualifier_ui | Q000379 |
| mesh[5].descriptor_ui | D004353 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | methods |
| mesh[5].descriptor_name | Drug Evaluation, Preclinical |
| mesh[6].qualifier_ui | Q000639 |
| mesh[6].descriptor_ui | D004353 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | trends |
| mesh[6].descriptor_name | Drug Evaluation, Preclinical |
| mesh[7].qualifier_ui | Q000187 |
| mesh[7].descriptor_ui | D004734 |
| mesh[7].is_major_topic | True |
| mesh[7].qualifier_name | drug effects |
| mesh[7].descriptor_name | Energy Metabolism |
| mesh[8].qualifier_ui | |
| mesh[8].descriptor_ui | D005583 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | |
| mesh[8].descriptor_name | Fourier Analysis |
| mesh[9].qualifier_ui | |
| mesh[9].descriptor_ui | D006801 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | |
| mesh[9].descriptor_name | Humans |
| mesh[10].qualifier_ui | |
| mesh[10].descriptor_ui | D009682 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | |
| mesh[10].descriptor_name | Magnetic Resonance Spectroscopy |
| mesh[11].qualifier_ui | |
| mesh[11].descriptor_ui | D013058 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | |
| mesh[11].descriptor_name | Mass Spectrometry |
| mesh[12].qualifier_ui | Q000379 |
| mesh[12].descriptor_ui | D055432 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | methods |
| mesh[12].descriptor_name | Metabolomics |
| mesh[13].qualifier_ui | Q000639 |
| mesh[13].descriptor_ui | D055432 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | trends |
| mesh[13].descriptor_name | Metabolomics |
| mesh[14].qualifier_ui | Q000188 |
| mesh[14].descriptor_ui | D009369 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | drug therapy |
| mesh[14].descriptor_name | Neoplasms |
| mesh[15].qualifier_ui | Q000201 |
| mesh[15].descriptor_ui | D009369 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | enzymology |
| mesh[15].descriptor_name | Neoplasms |
| mesh[16].qualifier_ui | Q000378 |
| mesh[16].descriptor_ui | D009369 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | metabolism |
| mesh[16].descriptor_name | Neoplasms |
| mesh[17].qualifier_ui | |
| mesh[17].descriptor_ui | D009587 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | |
| mesh[17].descriptor_name | Nitrogen Isotopes |
| mesh[18].qualifier_ui | |
| mesh[18].descriptor_ui | D000818 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | |
| mesh[18].descriptor_name | Animals |
| mesh[19].qualifier_ui | Q000494 |
| mesh[19].descriptor_ui | D000970 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | pharmacology |
| mesh[19].descriptor_name | Antineoplastic Agents |
| mesh[20].qualifier_ui | Q000627 |
| mesh[20].descriptor_ui | D000970 |
| mesh[20].is_major_topic | False |
| mesh[20].qualifier_name | therapeutic use |
| mesh[20].descriptor_name | Antineoplastic Agents |
| mesh[21].qualifier_ui | |
| mesh[21].descriptor_ui | D002247 |
| mesh[21].is_major_topic | False |
| mesh[21].qualifier_name | |
| mesh[21].descriptor_name | Carbon Isotopes |
| mesh[22].qualifier_ui | Q000187 |
| mesh[22].descriptor_ui | D065150 |
| mesh[22].is_major_topic | False |
| mesh[22].qualifier_name | drug effects |
| mesh[22].descriptor_name | Cellular Reprogramming |
| mesh[23].qualifier_ui | Q000379 |
| mesh[23].descriptor_ui | D004353 |
| mesh[23].is_major_topic | False |
| mesh[23].qualifier_name | methods |
| mesh[23].descriptor_name | Drug Evaluation, Preclinical |
| mesh[24].qualifier_ui | Q000639 |
| mesh[24].descriptor_ui | D004353 |
| mesh[24].is_major_topic | False |
| mesh[24].qualifier_name | trends |
| mesh[24].descriptor_name | Drug Evaluation, Preclinical |
| mesh[25].qualifier_ui | Q000187 |
| mesh[25].descriptor_ui | D004734 |
| mesh[25].is_major_topic | True |
| mesh[25].qualifier_name | drug effects |
| mesh[25].descriptor_name | Energy Metabolism |
| mesh[26].qualifier_ui | |
| mesh[26].descriptor_ui | D005583 |
| mesh[26].is_major_topic | False |
| mesh[26].qualifier_name | |
| mesh[26].descriptor_name | Fourier Analysis |
| mesh[27].qualifier_ui | |
| mesh[27].descriptor_ui | D006801 |
| mesh[27].is_major_topic | False |
| mesh[27].qualifier_name | |
| mesh[27].descriptor_name | Humans |
| mesh[28].qualifier_ui | |
| mesh[28].descriptor_ui | D009682 |
| mesh[28].is_major_topic | False |
| mesh[28].qualifier_name | |
| mesh[28].descriptor_name | Magnetic Resonance Spectroscopy |
| mesh[29].qualifier_ui | |
| mesh[29].descriptor_ui | D013058 |
| mesh[29].is_major_topic | False |
| mesh[29].qualifier_name | |
| mesh[29].descriptor_name | Mass Spectrometry |
| mesh[30].qualifier_ui | Q000379 |
| mesh[30].descriptor_ui | D055432 |
| mesh[30].is_major_topic | False |
| mesh[30].qualifier_name | methods |
| mesh[30].descriptor_name | Metabolomics |
| mesh[31].qualifier_ui | Q000639 |
| mesh[31].descriptor_ui | D055432 |
| mesh[31].is_major_topic | False |
| mesh[31].qualifier_name | trends |
| mesh[31].descriptor_name | Metabolomics |
| mesh[32].qualifier_ui | Q000188 |
| mesh[32].descriptor_ui | D009369 |
| mesh[32].is_major_topic | False |
| mesh[32].qualifier_name | drug therapy |
| mesh[32].descriptor_name | Neoplasms |
| mesh[33].qualifier_ui | Q000201 |
| mesh[33].descriptor_ui | D009369 |
| mesh[33].is_major_topic | False |
| mesh[33].qualifier_name | enzymology |
| mesh[33].descriptor_name | Neoplasms |
| mesh[34].qualifier_ui | Q000378 |
| mesh[34].descriptor_ui | D009369 |
| mesh[34].is_major_topic | False |
| mesh[34].qualifier_name | metabolism |
| mesh[34].descriptor_name | Neoplasms |
| mesh[35].qualifier_ui | |
| mesh[35].descriptor_ui | D009587 |
| mesh[35].is_major_topic | False |
| mesh[35].qualifier_name | |
| mesh[35].descriptor_name | Nitrogen Isotopes |
| mesh[36].qualifier_ui | |
| mesh[36].descriptor_ui | D000818 |
| mesh[36].is_major_topic | False |
| mesh[36].qualifier_name | |
| mesh[36].descriptor_name | Animals |
| mesh[37].qualifier_ui | Q000494 |
| mesh[37].descriptor_ui | D000970 |
| mesh[37].is_major_topic | False |
| mesh[37].qualifier_name | pharmacology |
| mesh[37].descriptor_name | Antineoplastic Agents |
| mesh[38].qualifier_ui | Q000627 |
| mesh[38].descriptor_ui | D000970 |
| mesh[38].is_major_topic | False |
| mesh[38].qualifier_name | therapeutic use |
| mesh[38].descriptor_name | Antineoplastic Agents |
| mesh[39].qualifier_ui | |
| mesh[39].descriptor_ui | D002247 |
| mesh[39].is_major_topic | False |
| mesh[39].qualifier_name | |
| mesh[39].descriptor_name | Carbon Isotopes |
| mesh[40].qualifier_ui | Q000187 |
| mesh[40].descriptor_ui | D065150 |
| mesh[40].is_major_topic | False |
| mesh[40].qualifier_name | drug effects |
| mesh[40].descriptor_name | Cellular Reprogramming |
| mesh[41].qualifier_ui | Q000379 |
| mesh[41].descriptor_ui | D004353 |
| mesh[41].is_major_topic | False |
| mesh[41].qualifier_name | methods |
| mesh[41].descriptor_name | Drug Evaluation, Preclinical |
| mesh[42].qualifier_ui | Q000639 |
| mesh[42].descriptor_ui | D004353 |
| mesh[42].is_major_topic | False |
| mesh[42].qualifier_name | trends |
| mesh[42].descriptor_name | Drug Evaluation, Preclinical |
| mesh[43].qualifier_ui | Q000187 |
| mesh[43].descriptor_ui | D004734 |
| mesh[43].is_major_topic | True |
| mesh[43].qualifier_name | drug effects |
| mesh[43].descriptor_name | Energy Metabolism |
| mesh[44].qualifier_ui | |
| mesh[44].descriptor_ui | D005583 |
| mesh[44].is_major_topic | False |
| mesh[44].qualifier_name | |
| mesh[44].descriptor_name | Fourier Analysis |
| mesh[45].qualifier_ui | |
| mesh[45].descriptor_ui | D006801 |
| mesh[45].is_major_topic | False |
| mesh[45].qualifier_name | |
| mesh[45].descriptor_name | Humans |
| mesh[46].qualifier_ui | |
| mesh[46].descriptor_ui | D009682 |
| mesh[46].is_major_topic | False |
| mesh[46].qualifier_name | |
| mesh[46].descriptor_name | Magnetic Resonance Spectroscopy |
| mesh[47].qualifier_ui | |
| mesh[47].descriptor_ui | D013058 |
| mesh[47].is_major_topic | False |
| mesh[47].qualifier_name | |
| mesh[47].descriptor_name | Mass Spectrometry |
| mesh[48].qualifier_ui | Q000379 |
| mesh[48].descriptor_ui | D055432 |
| mesh[48].is_major_topic | False |
| mesh[48].qualifier_name | methods |
| mesh[48].descriptor_name | Metabolomics |
| mesh[49].qualifier_ui | Q000639 |
| mesh[49].descriptor_ui | D055432 |
| mesh[49].is_major_topic | False |
| mesh[49].qualifier_name | trends |
| mesh[49].descriptor_name | Metabolomics |
| type | review |
| title | Exploring cancer metabolism using stable isotope-resolved metabolomics (SIRM) |
| biblio.issue | 28 |
| biblio.volume | 292 |
| biblio.last_page | 11609 |
| biblio.first_page | 11601 |
| grants[0].funder | https://openalex.org/F4320337351 |
| grants[0].award_id | 1P01CA163223–01A1 |
| grants[0].funder_display_name | National Cancer Institute |
| grants[1].funder | https://openalex.org/F4320337351 |
| grants[1].award_id | T32CA165990 |
| grants[1].funder_display_name | National Cancer Institute |
| grants[2].funder | https://openalex.org/F4320337357 |
| grants[2].award_id | |
| grants[2].funder_display_name | National Institute of Diabetes and Digestive and Kidney Diseases |
| grants[3].funder | https://openalex.org/F4320337361 |
| grants[3].award_id | 1R01ES022191–01 |
| grants[3].funder_display_name | National Institute of Environmental Health Sciences |
| topics[0].id | https://openalex.org/T10836 |
| topics[0].field.id | https://openalex.org/fields/13 |
| topics[0].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[0].score | 0.9998999834060669 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1312 |
| topics[0].subfield.display_name | Molecular Biology |
| topics[0].display_name | Metabolomics and Mass Spectrometry Studies |
| topics[1].id | https://openalex.org/T10631 |
| topics[1].field.id | https://openalex.org/fields/13 |
| topics[1].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[1].score | 0.9998000264167786 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1306 |
| topics[1].subfield.display_name | Cancer Research |
| topics[1].display_name | Cancer, Hypoxia, and Metabolism |
| topics[2].id | https://openalex.org/T10301 |
| topics[2].field.id | https://openalex.org/fields/13 |
| topics[2].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[2].score | 0.9846000075340271 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/1312 |
| topics[2].subfield.display_name | Molecular Biology |
| topics[2].display_name | Mitochondrial Function and Pathology |
| funders[0].id | https://openalex.org/F4320337351 |
| funders[0].ror | https://ror.org/040gcmg81 |
| funders[0].display_name | National Cancer Institute |
| funders[1].id | https://openalex.org/F4320337357 |
| funders[1].ror | https://ror.org/00adh9b73 |
| funders[1].display_name | National Institute of Diabetes and Digestive and Kidney Diseases |
| funders[2].id | https://openalex.org/F4320337361 |
| funders[2].ror | https://ror.org/00j4k1h63 |
| funders[2].display_name | National Institute of Environmental Health Sciences |
| is_xpac | False |
| apc_list.value | 2500 |
| apc_list.currency | USD |
| apc_list.value_usd | 2500 |
| apc_paid.value | 2500 |
| apc_paid.currency | USD |
| apc_paid.value_usd | 2500 |
| concepts[0].id | https://openalex.org/C21565614 |
| concepts[0].level | 2 |
| concepts[0].score | 0.7633687257766724 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q12149006 |
| concepts[0].display_name | Metabolomics |
| concepts[1].id | https://openalex.org/C185592680 |
| concepts[1].level | 0 |
| concepts[1].score | 0.530292809009552 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[1].display_name | Chemistry |
| concepts[2].id | https://openalex.org/C22117777 |
| concepts[2].level | 2 |
| concepts[2].score | 0.5234515070915222 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q17148629 |
| concepts[2].display_name | Stable isotope ratio |
| concepts[3].id | https://openalex.org/C107872376 |
| concepts[3].level | 1 |
| concepts[3].score | 0.48690974712371826 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q321355 |
| concepts[3].display_name | Environmental chemistry |
| concepts[4].id | https://openalex.org/C2986317502 |
| concepts[4].level | 2 |
| concepts[4].score | 0.43164128065109253 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q570714 |
| concepts[4].display_name | Energy metabolism |
| concepts[5].id | https://openalex.org/C62231903 |
| concepts[5].level | 2 |
| concepts[5].score | 0.4107932150363922 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q1057 |
| concepts[5].display_name | Metabolism |
| concepts[6].id | https://openalex.org/C70721500 |
| concepts[6].level | 1 |
| concepts[6].score | 0.3207961618900299 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q177005 |
| concepts[6].display_name | Computational biology |
| concepts[7].id | https://openalex.org/C86803240 |
| concepts[7].level | 0 |
| concepts[7].score | 0.2496192455291748 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[7].display_name | Biology |
| concepts[8].id | https://openalex.org/C43617362 |
| concepts[8].level | 1 |
| concepts[8].score | 0.24856731295585632 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q170050 |
| concepts[8].display_name | Chromatography |
| concepts[9].id | https://openalex.org/C55493867 |
| concepts[9].level | 1 |
| concepts[9].score | 0.24621587991714478 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[9].display_name | Biochemistry |
| concepts[10].id | https://openalex.org/C121332964 |
| concepts[10].level | 0 |
| concepts[10].score | 0.0810733437538147 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q413 |
| concepts[10].display_name | Physics |
| concepts[11].id | https://openalex.org/C62520636 |
| concepts[11].level | 1 |
| concepts[11].score | 0.0 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q944 |
| concepts[11].display_name | Quantum mechanics |
| concepts[12].id | https://openalex.org/C134018914 |
| concepts[12].level | 1 |
| concepts[12].score | 0.0 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q162606 |
| concepts[12].display_name | Endocrinology |
| keywords[0].id | https://openalex.org/keywords/metabolomics |
| keywords[0].score | 0.7633687257766724 |
| keywords[0].display_name | Metabolomics |
| keywords[1].id | https://openalex.org/keywords/chemistry |
| keywords[1].score | 0.530292809009552 |
| keywords[1].display_name | Chemistry |
| keywords[2].id | https://openalex.org/keywords/stable-isotope-ratio |
| keywords[2].score | 0.5234515070915222 |
| keywords[2].display_name | Stable isotope ratio |
| keywords[3].id | https://openalex.org/keywords/environmental-chemistry |
| keywords[3].score | 0.48690974712371826 |
| keywords[3].display_name | Environmental chemistry |
| keywords[4].id | https://openalex.org/keywords/energy-metabolism |
| keywords[4].score | 0.43164128065109253 |
| keywords[4].display_name | Energy metabolism |
| keywords[5].id | https://openalex.org/keywords/metabolism |
| keywords[5].score | 0.4107932150363922 |
| keywords[5].display_name | Metabolism |
| keywords[6].id | https://openalex.org/keywords/computational-biology |
| keywords[6].score | 0.3207961618900299 |
| keywords[6].display_name | Computational biology |
| keywords[7].id | https://openalex.org/keywords/biology |
| keywords[7].score | 0.2496192455291748 |
| keywords[7].display_name | Biology |
| keywords[8].id | https://openalex.org/keywords/chromatography |
| keywords[8].score | 0.24856731295585632 |
| keywords[8].display_name | Chromatography |
| keywords[9].id | https://openalex.org/keywords/biochemistry |
| keywords[9].score | 0.24621587991714478 |
| keywords[9].display_name | Biochemistry |
| keywords[10].id | https://openalex.org/keywords/physics |
| keywords[10].score | 0.0810733437538147 |
| keywords[10].display_name | Physics |
| language | en |
| locations[0].id | doi:10.1074/jbc.r117.776054 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S140251998 |
| locations[0].source.issn | 0021-9258, 1067-8816, 1083-351X |
| locations[0].source.type | journal |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | 0021-9258 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Journal of Biological Chemistry |
| locations[0].source.host_organization | https://openalex.org/P4310320990 |
| locations[0].source.host_organization_name | Elsevier BV |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320990 |
| locations[0].license | cc-by |
| locations[0].pdf_url | http://www.jbc.org/article/S0021925820370289/pdf |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Journal of Biological Chemistry |
| locations[0].landing_page_url | https://doi.org/10.1074/jbc.r117.776054 |
| locations[1].id | pmid:28592486 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | The Journal of biological chemistry |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/28592486 |
| locations[2].id | pmh:oai:europepmc.org:4995677 |
| locations[2].is_oa | False |
| locations[2].source.id | https://openalex.org/S4306400806 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | Europe PMC (PubMed Central) |
| locations[2].source.host_organization | https://openalex.org/I1303153112 |
| locations[2].source.host_organization_name | European Bioinformatics Institute |
| locations[2].source.host_organization_lineage | https://openalex.org/I1303153112 |
| locations[2].license | |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | |
| locations[2].landing_page_url | http://europepmc.org/pmc/articles/PMC5512057 |
| locations[3].id | pmh:oai:pubmedcentral.nih.gov:5512057 |
| locations[3].is_oa | True |
| locations[3].source.id | https://openalex.org/S2764455111 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | PubMed Central |
| locations[3].source.host_organization | https://openalex.org/I1299303238 |
| locations[3].source.host_organization_name | National Institutes of Health |
| locations[3].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[3].license | |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | Text |
| locations[3].license_id | |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | J Biol Chem |
| locations[3].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/5512057 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5033205170 |
| authorships[0].author.orcid | |
| authorships[0].author.display_name | Ronald C. Bruntz |
| authorships[0].countries | US |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I2802239656 |
| authorships[0].affiliations[0].raw_affiliation_string | Center for Environmental and Systems Biochemistry, Markey Cancer Center, Lexington, Kentucky 40506 |
| authorships[0].affiliations[1].institution_ids | https://openalex.org/I143302722 |
| authorships[0].affiliations[1].raw_affiliation_string | Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, Kentucky 40506 |
| authorships[0].institutions[0].id | https://openalex.org/I2802239656 |
| authorships[0].institutions[0].ror | https://ror.org/01dhvva97 |
| authorships[0].institutions[0].type | healthcare |
| authorships[0].institutions[0].lineage | https://openalex.org/I1285210727, https://openalex.org/I2802239656 |
| authorships[0].institutions[0].country_code | US |
| authorships[0].institutions[0].display_name | Markey Cancer Center |
| authorships[0].institutions[1].id | https://openalex.org/I143302722 |
| authorships[0].institutions[1].ror | https://ror.org/02k3smh20 |
| authorships[0].institutions[1].type | education |
| authorships[0].institutions[1].lineage | https://openalex.org/I143302722 |
| authorships[0].institutions[1].country_code | US |
| authorships[0].institutions[1].display_name | University of Kentucky |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Ronald C. Bruntz |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Center for Environmental and Systems Biochemistry, Markey Cancer Center, Lexington, Kentucky 40506, Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, Kentucky 40506 |
| authorships[1].author.id | https://openalex.org/A5029157205 |
| authorships[1].author.orcid | https://orcid.org/0000-0003-1121-5106 |
| authorships[1].author.display_name | Andrew N. Lane |
| authorships[1].countries | US |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I2802239656 |
| authorships[1].affiliations[0].raw_affiliation_string | Center for Environmental and Systems Biochemistry, Markey Cancer Center, Lexington, Kentucky 40506 |
| authorships[1].affiliations[1].institution_ids | https://openalex.org/I143302722 |
| authorships[1].affiliations[1].raw_affiliation_string | Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, Kentucky 40506 |
| authorships[1].institutions[0].id | https://openalex.org/I2802239656 |
| authorships[1].institutions[0].ror | https://ror.org/01dhvva97 |
| authorships[1].institutions[0].type | healthcare |
| authorships[1].institutions[0].lineage | https://openalex.org/I1285210727, https://openalex.org/I2802239656 |
| authorships[1].institutions[0].country_code | US |
| authorships[1].institutions[0].display_name | Markey Cancer Center |
| authorships[1].institutions[1].id | https://openalex.org/I143302722 |
| authorships[1].institutions[1].ror | https://ror.org/02k3smh20 |
| authorships[1].institutions[1].type | education |
| authorships[1].institutions[1].lineage | https://openalex.org/I143302722 |
| authorships[1].institutions[1].country_code | US |
| authorships[1].institutions[1].display_name | University of Kentucky |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Andrew N. Lane |
| authorships[1].is_corresponding | True |
| authorships[1].raw_affiliation_strings | Center for Environmental and Systems Biochemistry, Markey Cancer Center, Lexington, Kentucky 40506, Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, Kentucky 40506 |
| authorships[2].author.id | https://openalex.org/A5063823424 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-3256-0622 |
| authorships[2].author.display_name | Richard M. Higashi |
| authorships[2].countries | US |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I2802239656 |
| authorships[2].affiliations[0].raw_affiliation_string | Center for Environmental and Systems Biochemistry, Markey Cancer Center, Lexington, Kentucky 40506 |
| authorships[2].affiliations[1].institution_ids | https://openalex.org/I143302722 |
| authorships[2].affiliations[1].raw_affiliation_string | Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, Kentucky 40506 |
| authorships[2].institutions[0].id | https://openalex.org/I2802239656 |
| authorships[2].institutions[0].ror | https://ror.org/01dhvva97 |
| authorships[2].institutions[0].type | healthcare |
| authorships[2].institutions[0].lineage | https://openalex.org/I1285210727, https://openalex.org/I2802239656 |
| authorships[2].institutions[0].country_code | US |
| authorships[2].institutions[0].display_name | Markey Cancer Center |
| authorships[2].institutions[1].id | https://openalex.org/I143302722 |
| authorships[2].institutions[1].ror | https://ror.org/02k3smh20 |
| authorships[2].institutions[1].type | education |
| authorships[2].institutions[1].lineage | https://openalex.org/I143302722 |
| authorships[2].institutions[1].country_code | US |
| authorships[2].institutions[1].display_name | University of Kentucky |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Richard M. Higashi |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Center for Environmental and Systems Biochemistry, Markey Cancer Center, Lexington, Kentucky 40506, Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, Kentucky 40506 |
| authorships[3].author.id | https://openalex.org/A5070964312 |
| authorships[3].author.orcid | https://orcid.org/0000-0001-6478-4797 |
| authorships[3].author.display_name | Teresa W.‐M. Fan |
| authorships[3].countries | US |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I2802239656 |
| authorships[3].affiliations[0].raw_affiliation_string | Center for Environmental and Systems Biochemistry, Markey Cancer Center, Lexington, Kentucky 40506 |
| authorships[3].affiliations[1].institution_ids | https://openalex.org/I143302722 |
| authorships[3].affiliations[1].raw_affiliation_string | Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, Kentucky 40506 |
| authorships[3].institutions[0].id | https://openalex.org/I2802239656 |
| authorships[3].institutions[0].ror | https://ror.org/01dhvva97 |
| authorships[3].institutions[0].type | healthcare |
| authorships[3].institutions[0].lineage | https://openalex.org/I1285210727, https://openalex.org/I2802239656 |
| authorships[3].institutions[0].country_code | US |
| authorships[3].institutions[0].display_name | Markey Cancer Center |
| authorships[3].institutions[1].id | https://openalex.org/I143302722 |
| authorships[3].institutions[1].ror | https://ror.org/02k3smh20 |
| authorships[3].institutions[1].type | education |
| authorships[3].institutions[1].lineage | https://openalex.org/I143302722 |
| authorships[3].institutions[1].country_code | US |
| authorships[3].institutions[1].display_name | University of Kentucky |
| authorships[3].author_position | last |
| authorships[3].raw_author_name | Teresa W.-M. Fan |
| authorships[3].is_corresponding | True |
| authorships[3].raw_affiliation_strings | Center for Environmental and Systems Biochemistry, Markey Cancer Center, Lexington, Kentucky 40506, Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, Kentucky 40506 |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | http://www.jbc.org/article/S0021925820370289/pdf |
| open_access.oa_status | hybrid |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Exploring cancer metabolism using stable isotope-resolved metabolomics (SIRM) |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10836 |
| primary_topic.field.id | https://openalex.org/fields/13 |
| primary_topic.field.display_name | Biochemistry, Genetics and Molecular Biology |
| primary_topic.score | 0.9998999834060669 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1312 |
| primary_topic.subfield.display_name | Molecular Biology |
| primary_topic.display_name | Metabolomics and Mass Spectrometry Studies |
| related_works | https://openalex.org/W4283390424, https://openalex.org/W2137270828, https://openalex.org/W1976072307, https://openalex.org/W4205440119, https://openalex.org/W1561393703, https://openalex.org/W4292104203, https://openalex.org/W2040768604, https://openalex.org/W2096576371, https://openalex.org/W2947662853, https://openalex.org/W2412775339 |
| cited_by_count | 97 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 5 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 9 |
| counts_by_year[2].year | 2023 |
| counts_by_year[2].cited_by_count | 10 |
| counts_by_year[3].year | 2022 |
| counts_by_year[3].cited_by_count | 12 |
| counts_by_year[4].year | 2021 |
| counts_by_year[4].cited_by_count | 16 |
| counts_by_year[5].year | 2020 |
| counts_by_year[5].cited_by_count | 15 |
| counts_by_year[6].year | 2019 |
| counts_by_year[6].cited_by_count | 15 |
| counts_by_year[7].year | 2018 |
| counts_by_year[7].cited_by_count | 15 |
| locations_count | 4 |
| best_oa_location.id | doi:10.1074/jbc.r117.776054 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S140251998 |
| best_oa_location.source.issn | 0021-9258, 1067-8816, 1083-351X |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | 0021-9258 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Journal of Biological Chemistry |
| best_oa_location.source.host_organization | https://openalex.org/P4310320990 |
| best_oa_location.source.host_organization_name | Elsevier BV |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320990 |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | http://www.jbc.org/article/S0021925820370289/pdf |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Journal of Biological Chemistry |
| best_oa_location.landing_page_url | https://doi.org/10.1074/jbc.r117.776054 |
| primary_location.id | doi:10.1074/jbc.r117.776054 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S140251998 |
| primary_location.source.issn | 0021-9258, 1067-8816, 1083-351X |
| primary_location.source.type | journal |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | 0021-9258 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Journal of Biological Chemistry |
| primary_location.source.host_organization | https://openalex.org/P4310320990 |
| primary_location.source.host_organization_name | Elsevier BV |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320990 |
| primary_location.license | cc-by |
| primary_location.pdf_url | http://www.jbc.org/article/S0021925820370289/pdf |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Journal of Biological Chemistry |
| primary_location.landing_page_url | https://doi.org/10.1074/jbc.r117.776054 |
| publication_date | 2017-06-08 |
| publication_year | 2017 |
| referenced_works | https://openalex.org/W2097259163, https://openalex.org/W2162740426, https://openalex.org/W2055255976, https://openalex.org/W2041596211, https://openalex.org/W1985106139, https://openalex.org/W2117284175, https://openalex.org/W2009189236, https://openalex.org/W1995845139, https://openalex.org/W2253879855, https://openalex.org/W2102277559, https://openalex.org/W152894611, https://openalex.org/W1499832207, https://openalex.org/W1967981266, https://openalex.org/W2041987999, https://openalex.org/W2095246084, https://openalex.org/W2262766247, https://openalex.org/W2173466127, https://openalex.org/W2049759143, https://openalex.org/W2039220817, https://openalex.org/W2069269337, https://openalex.org/W2374279688, https://openalex.org/W2004571372, https://openalex.org/W1990912652, https://openalex.org/W2021158044, https://openalex.org/W1758280303, https://openalex.org/W2026781351, https://openalex.org/W2137386173, https://openalex.org/W2041729369, https://openalex.org/W2044565982, https://openalex.org/W2008421457, https://openalex.org/W2215229515, https://openalex.org/W1996480339, https://openalex.org/W2465746198, https://openalex.org/W4243903519, https://openalex.org/W2258066491, https://openalex.org/W2114805483, https://openalex.org/W2009999719, https://openalex.org/W1992060971, https://openalex.org/W2112963260, https://openalex.org/W1989008846, https://openalex.org/W1991106802, https://openalex.org/W2039343804, https://openalex.org/W2134294998, https://openalex.org/W2130784515, https://openalex.org/W2151980465, https://openalex.org/W2060592426, https://openalex.org/W2036659083, https://openalex.org/W2509261975, https://openalex.org/W2131170195, https://openalex.org/W2174361280, https://openalex.org/W2264411128, https://openalex.org/W2088545470, https://openalex.org/W2033958147, https://openalex.org/W2149343603, https://openalex.org/W2116516144, https://openalex.org/W2092152920, https://openalex.org/W2337267398, https://openalex.org/W2120553786, https://openalex.org/W2106318552, https://openalex.org/W1986991123, https://openalex.org/W1992524428, https://openalex.org/W6683894838, https://openalex.org/W2141517721, https://openalex.org/W2116057372, https://openalex.org/W2171228244, https://openalex.org/W2014988241, https://openalex.org/W2151184827, https://openalex.org/W2145757445, https://openalex.org/W2158107632, https://openalex.org/W2054657650, https://openalex.org/W2051181260, https://openalex.org/W2074873270, https://openalex.org/W1999565461, https://openalex.org/W1972593924, https://openalex.org/W2149852478, https://openalex.org/W2037338364, https://openalex.org/W2165868533, https://openalex.org/W2022770923, https://openalex.org/W2131719921, https://openalex.org/W2522492952, https://openalex.org/W1975918337, https://openalex.org/W2040827479, https://openalex.org/W1967291345, https://openalex.org/W1483430612, https://openalex.org/W2159594827, https://openalex.org/W2242964979, https://openalex.org/W1972205860, https://openalex.org/W2135003533, https://openalex.org/W1949900586, https://openalex.org/W149259628, https://openalex.org/W1892036645, https://openalex.org/W2274058631, https://openalex.org/W2411552143, https://openalex.org/W2468543693, https://openalex.org/W2119159785, https://openalex.org/W2090124334, https://openalex.org/W2135602302, https://openalex.org/W2120514137, https://openalex.org/W2010679017, https://openalex.org/W2023103376, https://openalex.org/W2091967608, https://openalex.org/W2289707431, https://openalex.org/W1996323185, https://openalex.org/W4210508355 |
| referenced_works_count | 104 |
| abstract_inverted_index.a | 3, 21, 65 |
| abstract_inverted_index.an | 29 |
| abstract_inverted_index.be | 62 |
| abstract_inverted_index.in | 9, 20, 88 |
| abstract_inverted_index.is | 2, 28 |
| abstract_inverted_index.of | 5, 35, 44, 68, 80 |
| abstract_inverted_index.on | 77 |
| abstract_inverted_index.to | 13, 40, 51, 53, 64, 82 |
| abstract_inverted_index.NMR | 36 |
| abstract_inverted_index.The | 7, 59 |
| abstract_inverted_index.and | 17, 37, 57, 85 |
| abstract_inverted_index.are | 11 |
| abstract_inverted_index.can | 61 |
| abstract_inverted_index.its | 86 |
| abstract_inverted_index.the | 42, 78 |
| abstract_inverted_index.use | 87 |
| abstract_inverted_index.SIRM | 81 |
| abstract_inverted_index.This | 74 |
| abstract_inverted_index.drug | 90 |
| abstract_inverted_index.fate | 43 |
| abstract_inverted_index.from | 47 |
| abstract_inverted_index.mass | 38 |
| abstract_inverted_index.that | 31 |
| abstract_inverted_index.uses | 32 |
| abstract_inverted_index.wide | 66 |
| abstract_inverted_index.atoms | 46 |
| abstract_inverted_index.harsh | 22 |
| abstract_inverted_index.human | 72 |
| abstract_inverted_index.range | 67 |
| abstract_inverted_index.(SIRM) | 27 |
| abstract_inverted_index.Stable | 24 |
| abstract_inverted_index.cancer | 83 |
| abstract_inverted_index.deduce | 54 |
| abstract_inverted_index.permit | 14 |
| abstract_inverted_index.review | 75 |
| abstract_inverted_index.stable | 48 |
| abstract_inverted_index.analyze | 41 |
| abstract_inverted_index.applied | 63 |
| abstract_inverted_index.cancer. | 6 |
| abstract_inverted_index.changes | 8 |
| abstract_inverted_index.focuses | 76 |
| abstract_inverted_index.actions. | 91 |
| abstract_inverted_index.adaptive | 12 |
| abstract_inverted_index.advanced | 33 |
| abstract_inverted_index.approach | 30, 60 |
| abstract_inverted_index.hallmark | 4 |
| abstract_inverted_index.pathways | 56 |
| abstract_inverted_index.products | 52 |
| abstract_inverted_index.systems, | 70 |
| abstract_inverted_index.Metabolic | 0 |
| abstract_inverted_index.including | 71 |
| abstract_inverted_index.metabolic | 55 |
| abstract_inverted_index.networks. | 58 |
| abstract_inverted_index.subjects. | 73 |
| abstract_inverted_index.survival, | 16 |
| abstract_inverted_index.approaches | 34 |
| abstract_inverted_index.biological | 69 |
| abstract_inverted_index.eventually | 18 |
| abstract_inverted_index.individual | 45 |
| abstract_inverted_index.metabolism | 10, 84 |
| abstract_inverted_index.metastasis | 19 |
| abstract_inverted_index.precursors | 50 |
| abstract_inverted_index.applications | 79 |
| abstract_inverted_index.environment. | 23 |
| abstract_inverted_index.metabolomics | 26 |
| abstract_inverted_index.spectrometry | 39 |
| abstract_inverted_index.reprogramming | 1 |
| abstract_inverted_index.understanding | 89 |
| abstract_inverted_index.proliferation, | 15 |
| abstract_inverted_index.isotope-enriched | 49 |
| abstract_inverted_index.isotope-resolved | 25 |
| cited_by_percentile_year.max | 100 |
| cited_by_percentile_year.min | 98 |
| corresponding_author_ids | https://openalex.org/A5070964312, https://openalex.org/A5029157205 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 4 |
| corresponding_institution_ids | https://openalex.org/I143302722, https://openalex.org/I2802239656 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.7200000286102295 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.96169259 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |