Exploring Self-Assembled Cationic Nanostructures of Amphiphilic β-Peptides for Amplifying Drug Delivery Efficiency Article Swipe
Rahul Goel
,
Mahesh Mangal
,
Aruna Sharma
,
Pradeep Kumar
,
Alka Gupta
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.14233/ajchem.2023.30738
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.14233/ajchem.2023.30738
In this study, a set of short sequences of amphiphilic peptides composed of synthetic amino acids β-alanine and ornithine were designed. The synthesis of these peptides was carried out in a solution phase and then self-assembled into cationic nanostructures. The formation of cationic nanostructures was confirmed using dynamic light scattering (DLS) and the morphology of the nanostructures was studied using transmission electron microscopy (TEM), which revealed that the nanostructure adopted a spherical shape. To gain insight into the conformation of both solid samples and peptide solutions, the Fourier transform infrared (FTIR) and circular dichroism (CD) spectroscopic analysis were performed. Furthermore, the ability of these nanostructures to encapsulate hydrophobic drugs were also investigated. Three different drugs were tested as model drugs: L-dopa, an anti-Parkinson’s drug; curcumin, anti-cancerous drug and tetrabenazine, anti-Huntington’s drug. The nanostructures exhibited the capacity to encapsulate these drugs in varying ratios.
Related Topics
Concepts
Chemistry
Cationic polymerization
Amphiphile
Nanostructure
Dynamic light scattering
Drug delivery
Circular dichroism
Peptide
Transmission electron microscopy
Fourier transform infrared spectroscopy
Self-assembly
Combinatorial chemistry
Biophysics
Chemical engineering
Stereochemistry
Nanotechnology
Nanoparticle
Organic chemistry
Copolymer
Biochemistry
Materials science
Polymer
Biology
Engineering
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.14233/ajchem.2023.30738
- https://asianpubs.org/index.php/ajchem/article/download/35_12_31/29422
- OA Status
- diamond
- Cited By
- 1
- References
- 19
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4389273746
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4389273746Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.14233/ajchem.2023.30738Digital Object Identifier
- Title
-
Exploring Self-Assembled Cationic Nanostructures of Amphiphilic β-Peptides for Amplifying Drug Delivery EfficiencyWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-12-02Full publication date if available
- Authors
-
Rahul Goel, Mahesh Mangal, Aruna Sharma, Pradeep Kumar, Alka GuptaList of authors in order
- Landing page
-
https://doi.org/10.14233/ajchem.2023.30738Publisher landing page
- PDF URL
-
https://asianpubs.org/index.php/ajchem/article/download/35_12_31/29422Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
diamondOpen access status per OpenAlex
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https://asianpubs.org/index.php/ajchem/article/download/35_12_31/29422Direct OA link when available
- Concepts
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Chemistry, Cationic polymerization, Amphiphile, Nanostructure, Dynamic light scattering, Drug delivery, Circular dichroism, Peptide, Transmission electron microscopy, Fourier transform infrared spectroscopy, Self-assembly, Combinatorial chemistry, Biophysics, Chemical engineering, Stereochemistry, Nanotechnology, Nanoparticle, Organic chemistry, Copolymer, Biochemistry, Materials science, Polymer, Biology, EngineeringTop concepts (fields/topics) attached by OpenAlex
- Cited by
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1Total citation count in OpenAlex
- Citations by year (recent)
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2024: 1Per-year citation counts (last 5 years)
- References (count)
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19Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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