Exploring shared mechanisms between ulcerative colitis and psoriasis and predicting therapeutic natural compounds through bioinformatics and molecular docking Article Swipe
Yixuan Yang
,
Zhuozhi Gong
,
Jiao Yang
,
Ying Cai
,
Shengwei Hong
,
Wenjun Mao
,
Zijian Guo
,
Mengting Qiu
,
Zhu Fan
,
Bingnan Cui
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.heliyon.2024.e37624
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.heliyon.2024.e37624
MMP9, MMP1, and CXCL10, central mediators in the inflammatory pathways of UC and PS, establish a shared mechanism by triggering cytokine and chemokine activation, leading to tissue damage and positioning them as promising therapeutic targets for both conditions. Compounds such as quercetin, luteolin, irisolidone, rutaecarpine, and so on may be key drugs for treating both conditions. These findings suggest the potential advancement of therapeutic strategies and the enhancement of patient care by exploring shared mechanisms and predicting promising natural compounds for treating UC and PS.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.heliyon.2024.e37624
- OA Status
- gold
- Cited By
- 3
- References
- 116
- Related Works
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- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4402334102Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1016/j.heliyon.2024.e37624Digital Object Identifier
- Title
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Exploring shared mechanisms between ulcerative colitis and psoriasis and predicting therapeutic natural compounds through bioinformatics and molecular dockingWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-09-01Full publication date if available
- Authors
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Yixuan Yang, Zhuozhi Gong, Jiao Yang, Ying Cai, Shengwei Hong, Wenjun Mao, Zijian Guo, Mengting Qiu, Zhu Fan, Bingnan CuiList of authors in order
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https://doi.org/10.1016/j.heliyon.2024.e37624Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.1016/j.heliyon.2024.e37624Direct OA link when available
- Concepts
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Ulcerative colitis, Psoriasis, Computational biology, Bioinformatics, Medicine, Biology, Disease, Dermatology, Internal medicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
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3Total citation count in OpenAlex
- Citations by year (recent)
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2025: 3Per-year citation counts (last 5 years)
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116Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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