Exploring structural features and potential lipid interactions of Pseudomonas aeruginosa type three secretion effector PemB by spectroscopic and calorimetric experiments
Article Swipe
Arkaprabha Choudhury
,
Saumen Saha
,
Nakul C. Maiti
,
Saumen Datta
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1002/pro.4627
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1002/pro.4627
Type Three Secretion System (T3SS) is a sophisticated nano‐scale weapon utilized by several gram negative bacteria under stringent spatio‐temporal regulation to manipulate and evade host immune systems in order to cause infection. To the best of our knowledge, this present study is the first report where we embark upon characterizing inherent features of native type three secretion effector protein PemB through biophysical techniques. Herein, first, we demonstrate binding affinity of PemB for phosphoinositides through isothermal calorimetric titrations. Second, we shed light on its strong homo‐oligomerization propensity in aqueous solution through multiple biophysical methods. Third, we also employ several spectroscopic techniques to delineate its disordered and helical conformation. Lastly, we perform a phylogenetic analysis of this new effector to elucidate evolutionary relationship with other organisms. Taken together, our results shall surely contribute to our existing knowledge of Pseudomonas aeruginosa secretome.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/pro.4627
- OA Status
- green
- Cited By
- 3
- References
- 90
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4324130322
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4324130322Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1002/pro.4627Digital Object Identifier
- Title
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Exploring structural features and potential lipid interactions of Pseudomonas aeruginosa type three secretion effector
PemB by spectroscopic and calorimetric experimentsWork title - Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-03-14Full publication date if available
- Authors
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Arkaprabha Choudhury, Saumen Saha, Nakul C. Maiti, Saumen DattaList of authors in order
- Landing page
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https://doi.org/10.1002/pro.4627Publisher landing page
- Open access
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
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https://pmc.ncbi.nlm.nih.gov/articles/PMC10044109/pdf/PRO-32-e4627.pdfDirect OA link when available
- Concepts
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Effector, Secretion, Isothermal titration calorimetry, Pseudomonas aeruginosa, Computational biology, Biology, Titration, Type three secretion system, Chemistry, Bacteria, Biophysics, Cell biology, Biochemistry, Genetics, Virulence, Gene, Inorganic chemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
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3Total citation count in OpenAlex
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2024: 1, 2023: 2Per-year citation counts (last 5 years)
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90Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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