Exploring the Anti-Alzheimer’s Disease Potential of Aspergillus terreus C23-3 Through Genomic Insights, Metabolomic Analysis, and Molecular Docking Article Swipe
Zeyuan Ma
,
Longjian Zhou
,
Zhiyou Yang
,
Yayue Liu
,
Yi Zhang
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/jof11080546
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/jof11080546
Alzheimer’s disease (AD) is a prevalent neurodegenerative disorder with a pressing need for novel therapeutics. However, current medications only offer symptomatic relief, without tackling the underlying pathology. To explore the bioactive potential of marine-derived fungi, this study focused on Aspergillus terreus C23-3, a strain isolated from the coral Pavona cactus in Xuwen County, China, which showed a richer metabolite fingerprint among the three deposited A. terreus strains. AntiSMASH analysis based on complete genome sequencing predicted 68 biosynthetic gene clusters (BGCs) with 7 BGCs synthesizing compounds reported to have anti-AD potential, including benzodiazepines, benzaldehydes, butenolides, and lovastatin. Liquid chromatography coupled with mass spectrometry (LC-MS)-based combinational metabolomic annotation verified most of the compounds predicted by BGCs with the acetylcholinesterase (AChE) inhibitor territrem B characterized from its fermentation extract. Subsequently, molecular docking showed that these compounds, especially aspulvione B1, possessed strong interactions with AD-related targets including AChE, cyclin-dependent kinase 5-p25 complex (CDK5/p25), glycogen synthase kinase-3β (GSK-3β), and monoamine oxidase-B (MAO-B). In conclusion, the genomic–metabolomic analyses and molecular docking indicated that C23-3 is a high-value source strain for anti-AD natural compounds.
Related Topics
Concepts
Aspergillus terreus
Metabolomics
Biology
Aspergillus nidulans
Biochemistry
Metabolite
Computational biology
Gene
Bioinformatics
Mutant
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/jof11080546
- https://www.mdpi.com/2309-608X/11/8/546/pdf?version=1753267444
- OA Status
- gold
- Cited By
- 1
- References
- 81
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4412614250
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4412614250Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/jof11080546Digital Object Identifier
- Title
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Exploring the Anti-Alzheimer’s Disease Potential of Aspergillus terreus C23-3 Through Genomic Insights, Metabolomic Analysis, and Molecular DockingWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-07-23Full publication date if available
- Authors
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Zeyuan Ma, Longjian Zhou, Zhiyou Yang, Yayue Liu, Yi ZhangList of authors in order
- Landing page
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https://doi.org/10.3390/jof11080546Publisher landing page
- PDF URL
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https://www.mdpi.com/2309-608X/11/8/546/pdf?version=1753267444Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://www.mdpi.com/2309-608X/11/8/546/pdf?version=1753267444Direct OA link when available
- Concepts
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Aspergillus terreus, Metabolomics, Biology, Aspergillus nidulans, Biochemistry, Metabolite, Computational biology, Gene, Bioinformatics, MutantTop concepts (fields/topics) attached by OpenAlex
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1Total citation count in OpenAlex
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2025: 1Per-year citation counts (last 5 years)
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81Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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