Exploring the Causal Relationship Between Blood Metabolites and Chronic Periodontitis: Insights From Genetic Causal Analysis Article Swipe
Wenzhi Cai
,
Huaxuan Zhao
,
Panpan Wang
,
Xiaohong Chen
,
Yumeng Yang
,
Hongle Wu
,
Zehao Chen
,
Fuchun Fang
,
Wei Qiu
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1111/jcmm.70938
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1111/jcmm.70938
To investigate the potential bidirectional causal relationship between specific blood metabolites and chronic periodontitis using Mendelian randomisation (MR). A two‐sample bidirectional MR analysis was conducted. Data on 1400 blood metabolites were obtained from a genome‐wide association study involving 8299 participants. Chronic periodontitis data were sourced from the FinnGen consortium, comprising 4784 cases and 272,252 controls. The primary analysis involved the inverse‐variance weighted (IVW) method. Furthermore, a metabolic pathway enrichment analysis was conducted on the metabolites identified by the IVW method. Following IVW and sensitivity analyses, 60 blood metabolites were found to be associated with chronic periodontitis. Metabolic pathway analysis suggested that these metabolites may influence chronic periodontitis through four pathways: pyrimidine metabolism, glycine, serine and threonine metabolism, arginine and proline metabolism and riboflavin metabolism. Reverse MR analysis indicated that chronic periodontitis could alter the levels of 47 blood metabolites. Pathway analysis revealed that chronic periodontitis might affect blood metabolite levels through four pathways: vitamin B6 metabolism, ether lipid metabolism, glycerophospholipid metabolism and caffeine metabolism. This study provides new insights into the pathogenesis of periodontitis, identifying potential blood biomarkers for early detection and monitoring.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1111/jcmm.70938
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jcmm.70938
- OA Status
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- References
- 32
- OpenAlex ID
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All OpenAlex metadata
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https://openalex.org/W4415731871Canonical identifier for this work in OpenAlex
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https://doi.org/10.1111/jcmm.70938Digital Object Identifier
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Exploring the Causal Relationship Between Blood Metabolites and Chronic Periodontitis: Insights From Genetic Causal AnalysisWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-10-31Full publication date if available
- Authors
-
Wenzhi Cai, Huaxuan Zhao, Panpan Wang, Xiaohong Chen, Yumeng Yang, Hongle Wu, Zehao Chen, Fuchun Fang, Wei QiuList of authors in order
- Landing page
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https://doi.org/10.1111/jcmm.70938Publisher landing page
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jcmm.70938Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jcmm.70938Direct OA link when available
- Cited by
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0Total citation count in OpenAlex
- References (count)
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32Number of works referenced by this work
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