Exploring the Connection Between Depression, Inflammatory Biomarkers, and Atherosclerotic Coronary Artery Disease Article Swipe
Marius Rus
,
Cristian Sava
,
Adriana Ioana Ardelean
,
Georgeta Pașca
,
Felicia Liana Andronie-Cioară
,
Simina Crişan
,
Claudia Teodora Judea Pusta
,
Madalina Ioana Guler
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/jcm14092946
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/jcm14092946
Background/Objectives: Depression is associated with an increased risk for the development and progression of cardiovascular disease. This research investigated the association between depressive symptoms and inflammation in the development of atherosclerotic coronary events. Methods: This retrospective observational study included 276 patients who were not previously diagnosed with atherosclerotic coronary artery disease at the beginning of the research. Participants were categorized using the Hamilton Depression Rating Scale (HDRS) and the Structured Clinical Interview for DSM-5 (SCID) into two groups: the depression group and the control group. Inflammatory biomarkers (C-reactive protein (CRP), fibrinogen, interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and cortisol) were measured at the beginning of the study, as well as at six months, one year, and two years. Results: Among patients with mild depression (17.3% vs. 4.2%) or moderate depression (15.4% vs. 6.7%), there were significantly more men than women, while among patients with very severe depression, there were significantly more women than men (21.7% vs. 11.5%). Participants with depression showed significantly higher increases at 2 years compared to baseline for all investigated parameters (p < 0.001). Depressed patients were significantly associated with an acute coronary syndrome (p = 0.038). Conclusions: This research highlights that individuals with depression face a greater risk of developing an acute coronary syndrome than those without depression.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/jcm14092946
- https://www.mdpi.com/2077-0383/14/9/2946/pdf?version=1745499872
- OA Status
- gold
- Cited By
- 2
- References
- 56
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4409766541
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4409766541Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/jcm14092946Digital Object Identifier
- Title
-
Exploring the Connection Between Depression, Inflammatory Biomarkers, and Atherosclerotic Coronary Artery DiseaseWork title
- Type
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articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-04-24Full publication date if available
- Authors
-
Marius Rus, Cristian Sava, Adriana Ioana Ardelean, Georgeta Pașca, Felicia Liana Andronie-Cioară, Simina Crişan, Claudia Teodora Judea Pusta, Madalina Ioana GulerList of authors in order
- Landing page
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https://doi.org/10.3390/jcm14092946Publisher landing page
- PDF URL
-
https://www.mdpi.com/2077-0383/14/9/2946/pdf?version=1745499872Direct link to full text PDF
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://www.mdpi.com/2077-0383/14/9/2946/pdf?version=1745499872Direct OA link when available
- Concepts
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Medicine, Depression (economics), Internal medicine, Coronary artery disease, Acute coronary syndrome, C-reactive protein, Fibrinogen, Observational study, Disease, Inflammation, Cardiology, Physical therapy, Myocardial infarction, Macroeconomics, EconomicsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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2Total citation count in OpenAlex
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2025: 2Per-year citation counts (last 5 years)
- References (count)
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56Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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