Exploring the Intersection of Cellular Regulation, Aging, and Disease Insights into Mechanisms and Implications Article Swipe
Imran Rashid
,
Rajip Nepa
,
Abhishek Kumar
,
Navneet Kaur
,
Dr Mohit Kumar
,
Dr Loveleen Preet Kaur
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.47191/ijpbms/v4-i4-24
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.47191/ijpbms/v4-i4-24
This thorough analysis explores the complex interactions between aging, the beginning of different diseases, and cellular control, with a special emphasis on neurodegeneration. Sustaining cellular homeostasis requires cellular regulation, which includes signaling pathways, proteostasis, and organelle communication. Age-related problems can result from intricate pathways that are currently poorly understood. These disorders range from cardiovascular ailments to neurodegenerative conditions like Alzheimer's and Parkinson's diseases. Oxidative stress is a major contributor to metabolic syndrome and aging. It is caused by an imbalance between the formations of reactive oxygen species (ROS) and antioxidant defense mechanisms. Moreover, changes in intracellular pH levels have been connected to neurodegenerative illnesses and the aging process, suggesting a new direction for research into the causes of and possible preventions for age-related neurodegeneration. Autophagy is an essential process for cellular upkeep that is critical to neurodegenerative pathways and brain aging because it promotes the breakdown of toxic chemicals and damaged organelles. Furthermore, aging and longevity are greatly influenced by the reduction in cellular energy metabolism, which is controlled by conserved pathways including mTORC and insulin/IGF1. Furthermore, it is noted that protein misfolding and aggregation are essential mechanisms in neurodegenerative illnesses that cause neuronal populations to malfunction and die. Knowing how these variables interact dynamically offers important insights into the pathophysiology of disease and the dynamics of aging, perhaps pointing to new therapeutic targets for the prevention and treatment of age-related disorders.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.47191/ijpbms/v4-i4-24
- https://ijpbms.com/index.php/ijpbms/article/download/516/350
- OA Status
- diamond
- References
- 41
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4396556766
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4396556766Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.47191/ijpbms/v4-i4-24Digital Object Identifier
- Title
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Exploring the Intersection of Cellular Regulation, Aging, and Disease Insights into Mechanisms and ImplicationsWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-03-30Full publication date if available
- Authors
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Imran Rashid, Rajip Nepa, Abhishek Kumar, Navneet Kaur, Dr Mohit Kumar, Dr Loveleen Preet KaurList of authors in order
- Landing page
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https://doi.org/10.47191/ijpbms/v4-i4-24Publisher landing page
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https://ijpbms.com/index.php/ijpbms/article/download/516/350Direct link to full text PDF
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YesWhether a free full text is available
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diamondOpen access status per OpenAlex
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https://ijpbms.com/index.php/ijpbms/article/download/516/350Direct OA link when available
- Concepts
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Proteostasis, Neurodegeneration, Autophagy, Biology, Neuroscience, Disease, Oxidative stress, Aging brain, Cellular stress response, Mitochondrion, Cell biology, Medicine, Fight-or-flight response, Genetics, Biochemistry, Apoptosis, Pathology, Gene, CognitionTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- References (count)
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41Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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