Exploring the Obesity Paradox in A Murine Model of Sepsis: Improved Survival Despite Increased Organ Injury in Obese Mice Article Swipe
Erick D. Lewis
,
Holden C. Williams
,
Maria E. C. Bruno
,
Arnold J. Stromberg
,
Hiroshi Saitō
,
Lance A. Johnson
,
Marlene E. Starr
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1097/shk.0000000000001856
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1097/shk.0000000000001856
Despite the known deleterious effects of obesity, clinical data indicate that overweight or obese patients experience higher rates of sepsis survival compared to normal and underweight patients; a phenomenon called the obesity paradox. Results from preclinical sepsis studies have not been able to replicate these findings. The objective of this study was to test the existence of the obesity paradox in a murine model of cecal slurry (CS)-induced sepsis with insulin-resistant diet-induced obese mice. Male C57BL/6 mice were provided high-fat (HFD) or low-fat (LFD) diets for 20 weeks. HFD-fed mice experienced higher rates of survival compared to LFD-fed mice after septic challenge induced by CS injection (66% vs. 25%, P = 0.01, survival assessed for 14 days). Despite the survival advantage, HFD-fed mice had higher rates of positive bacterial cultures and increased markers of kidney injury. Circulating levels of IL-6, IL-1β, TNFα, and IL-23 were equivalent 24 h after CS-injection; however, IL-17A was uniquely increased in HFD-fed mice. While LFD-fed mice maintained euglycemia, HFD-fed mice were hyperglycemic 6 and 12 h after CS-injection. Stable isotope resolved metabolomics analysis of liver tissue showed diverging pathways of glucose utilization during sepsis, with LFD-fed mice significantly upregulating glycolytic activity and HFD-fed mice decreasing glucose entry into the TCA cycle. This murine study corroborates clinical data that obesity confers a survival benefit in sepsis, albeit at the expense of more significant organ injury. The mechanisms promoting survival in the obese remain unknown; however, this model appears to be well-poised to begin answering this question. Differences in glucose utilization are a novel target to investigate this paradox.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1097/shk.0000000000001856
- OA Status
- green
- Cited By
- 18
- References
- 48
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3197076630
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3197076630Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1097/shk.0000000000001856Digital Object Identifier
- Title
-
Exploring the Obesity Paradox in A Murine Model of Sepsis: Improved Survival Despite Increased Organ Injury in Obese MiceWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-09-02Full publication date if available
- Authors
-
Erick D. Lewis, Holden C. Williams, Maria E. C. Bruno, Arnold J. Stromberg, Hiroshi Saitō, Lance A. Johnson, Marlene E. StarrList of authors in order
- Landing page
-
https://doi.org/10.1097/shk.0000000000001856Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.ncbi.nlm.nih.gov/pmc/articles/8678195Direct OA link when available
- Concepts
-
Sepsis, Overweight, Internal medicine, Endocrinology, Medicine, Obesity, Lipopolysaccharide, Glycolysis, Kidney, Underweight, MetabolismTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
18Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 6, 2024: 8, 2023: 3, 2022: 1Per-year citation counts (last 5 years)
- References (count)
-
48Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W3197076630 |
|---|---|
| doi | https://doi.org/10.1097/shk.0000000000001856 |
| ids.doi | https://doi.org/10.1097/shk.0000000000001856 |
| ids.mag | 3197076630 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/34482320 |
| ids.openalex | https://openalex.org/W3197076630 |
| fwci | 2.24014525 |
| mesh[0].qualifier_ui | Q000097 |
| mesh[0].descriptor_ui | D058186 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | blood |
| mesh[0].descriptor_name | Acute Kidney Injury |
| mesh[1].qualifier_ui | |
| mesh[1].descriptor_ui | D000818 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | |
| mesh[1].descriptor_name | Animals |
| mesh[2].qualifier_ui | Q000097 |
| mesh[2].descriptor_ui | D016207 |
| mesh[2].is_major_topic | False |
| mesh[2].qualifier_name | blood |
| mesh[2].descriptor_name | Cytokines |
| mesh[3].qualifier_ui | |
| mesh[3].descriptor_ui | D059305 |
| mesh[3].is_major_topic | False |
| mesh[3].qualifier_name | |
| mesh[3].descriptor_name | Diet, High-Fat |
| mesh[4].qualifier_ui | |
| mesh[4].descriptor_ui | D004195 |
| mesh[4].is_major_topic | False |
| mesh[4].qualifier_name | |
| mesh[4].descriptor_name | Disease Models, Animal |
| mesh[5].qualifier_ui | Q000097 |
| mesh[5].descriptor_ui | D007378 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | blood |
| mesh[5].descriptor_name | Interleukins |
| mesh[6].qualifier_ui | |
| mesh[6].descriptor_ui | D008810 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | |
| mesh[6].descriptor_name | Mice, Inbred C57BL |
| mesh[7].qualifier_ui | |
| mesh[7].descriptor_ui | D008820 |
| mesh[7].is_major_topic | True |
| mesh[7].qualifier_name | |
| mesh[7].descriptor_name | Mice, Obese |
| mesh[8].qualifier_ui | Q000097 |
| mesh[8].descriptor_ui | D018805 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | blood |
| mesh[8].descriptor_name | Sepsis |
| mesh[9].qualifier_ui | Q000401 |
| mesh[9].descriptor_ui | D018805 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | mortality |
| mesh[9].descriptor_name | Sepsis |
| mesh[10].qualifier_ui | Q000097 |
| mesh[10].descriptor_ui | D014409 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | blood |
| mesh[10].descriptor_name | Tumor Necrosis Factor-alpha |
| mesh[11].qualifier_ui | Q000097 |
| mesh[11].descriptor_ui | D058186 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | blood |
| mesh[11].descriptor_name | Acute Kidney Injury |
| mesh[12].qualifier_ui | |
| mesh[12].descriptor_ui | D000818 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | |
| mesh[12].descriptor_name | Animals |
| mesh[13].qualifier_ui | Q000097 |
| mesh[13].descriptor_ui | D016207 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | blood |
| mesh[13].descriptor_name | Cytokines |
| mesh[14].qualifier_ui | |
| mesh[14].descriptor_ui | D059305 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | |
| mesh[14].descriptor_name | Diet, High-Fat |
| mesh[15].qualifier_ui | |
| mesh[15].descriptor_ui | D004195 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | |
| mesh[15].descriptor_name | Disease Models, Animal |
| mesh[16].qualifier_ui | Q000097 |
| mesh[16].descriptor_ui | D007378 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | blood |
| mesh[16].descriptor_name | Interleukins |
| mesh[17].qualifier_ui | |
| mesh[17].descriptor_ui | D008810 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | |
| mesh[17].descriptor_name | Mice, Inbred C57BL |
| mesh[18].qualifier_ui | |
| mesh[18].descriptor_ui | D008820 |
| mesh[18].is_major_topic | True |
| mesh[18].qualifier_name | |
| mesh[18].descriptor_name | Mice, Obese |
| mesh[19].qualifier_ui | Q000097 |
| mesh[19].descriptor_ui | D018805 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | blood |
| mesh[19].descriptor_name | Sepsis |
| mesh[20].qualifier_ui | Q000401 |
| mesh[20].descriptor_ui | D018805 |
| mesh[20].is_major_topic | False |
| mesh[20].qualifier_name | mortality |
| mesh[20].descriptor_name | Sepsis |
| mesh[21].qualifier_ui | Q000097 |
| mesh[21].descriptor_ui | D014409 |
| mesh[21].is_major_topic | False |
| mesh[21].qualifier_name | blood |
| mesh[21].descriptor_name | Tumor Necrosis Factor-alpha |
| mesh[22].qualifier_ui | |
| mesh[22].descriptor_ui | D051379 |
| mesh[22].is_major_topic | False |
| mesh[22].qualifier_name | |
| mesh[22].descriptor_name | Mice |
| mesh[23].qualifier_ui | Q000097 |
| mesh[23].descriptor_ui | D058186 |
| mesh[23].is_major_topic | False |
| mesh[23].qualifier_name | blood |
| mesh[23].descriptor_name | Acute Kidney Injury |
| mesh[24].qualifier_ui | |
| mesh[24].descriptor_ui | D000818 |
| mesh[24].is_major_topic | False |
| mesh[24].qualifier_name | |
| mesh[24].descriptor_name | Animals |
| mesh[25].qualifier_ui | Q000097 |
| mesh[25].descriptor_ui | D016207 |
| mesh[25].is_major_topic | False |
| mesh[25].qualifier_name | blood |
| mesh[25].descriptor_name | Cytokines |
| mesh[26].qualifier_ui | |
| mesh[26].descriptor_ui | D059305 |
| mesh[26].is_major_topic | False |
| mesh[26].qualifier_name | |
| mesh[26].descriptor_name | Diet, High-Fat |
| mesh[27].qualifier_ui | |
| mesh[27].descriptor_ui | D004195 |
| mesh[27].is_major_topic | False |
| mesh[27].qualifier_name | |
| mesh[27].descriptor_name | Disease Models, Animal |
| mesh[28].qualifier_ui | Q000097 |
| mesh[28].descriptor_ui | D007378 |
| mesh[28].is_major_topic | False |
| mesh[28].qualifier_name | blood |
| mesh[28].descriptor_name | Interleukins |
| mesh[29].qualifier_ui | |
| mesh[29].descriptor_ui | D008810 |
| mesh[29].is_major_topic | False |
| mesh[29].qualifier_name | |
| mesh[29].descriptor_name | Mice, Inbred C57BL |
| mesh[30].qualifier_ui | |
| mesh[30].descriptor_ui | D008820 |
| mesh[30].is_major_topic | True |
| mesh[30].qualifier_name | |
| mesh[30].descriptor_name | Mice, Obese |
| mesh[31].qualifier_ui | Q000097 |
| mesh[31].descriptor_ui | D018805 |
| mesh[31].is_major_topic | False |
| mesh[31].qualifier_name | blood |
| mesh[31].descriptor_name | Sepsis |
| mesh[32].qualifier_ui | Q000401 |
| mesh[32].descriptor_ui | D018805 |
| mesh[32].is_major_topic | False |
| mesh[32].qualifier_name | mortality |
| mesh[32].descriptor_name | Sepsis |
| mesh[33].qualifier_ui | Q000097 |
| mesh[33].descriptor_ui | D014409 |
| mesh[33].is_major_topic | False |
| mesh[33].qualifier_name | blood |
| mesh[33].descriptor_name | Tumor Necrosis Factor-alpha |
| mesh[34].qualifier_ui | |
| mesh[34].descriptor_ui | D051379 |
| mesh[34].is_major_topic | False |
| mesh[34].qualifier_name | |
| mesh[34].descriptor_name | Mice |
| type | article |
| title | Exploring the Obesity Paradox in A Murine Model of Sepsis: Improved Survival Despite Increased Organ Injury in Obese Mice |
| biblio.issue | 1 |
| biblio.volume | 57 |
| biblio.last_page | 159 |
| biblio.first_page | 151 |
| topics[0].id | https://openalex.org/T10218 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9994000196456909 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2713 |
| topics[0].subfield.display_name | Epidemiology |
| topics[0].display_name | Sepsis Diagnosis and Treatment |
| topics[1].id | https://openalex.org/T11623 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9958999752998352 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2712 |
| topics[1].subfield.display_name | Endocrinology, Diabetes and Metabolism |
| topics[1].display_name | Hyperglycemia and glycemic control in critically ill and hospitalized patients |
| topics[2].id | https://openalex.org/T11171 |
| topics[2].field.id | https://openalex.org/fields/13 |
| topics[2].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[2].score | 0.9866999983787537 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/1311 |
| topics[2].subfield.display_name | Genetics |
| topics[2].display_name | Diabetes and associated disorders |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C2778384902 |
| concepts[0].level | 2 |
| concepts[0].score | 0.838583767414093 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q183134 |
| concepts[0].display_name | Sepsis |
| concepts[1].id | https://openalex.org/C2780586474 |
| concepts[1].level | 3 |
| concepts[1].score | 0.6662616729736328 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q332428 |
| concepts[1].display_name | Overweight |
| concepts[2].id | https://openalex.org/C126322002 |
| concepts[2].level | 1 |
| concepts[2].score | 0.6193833351135254 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[2].display_name | Internal medicine |
| concepts[3].id | https://openalex.org/C134018914 |
| concepts[3].level | 1 |
| concepts[3].score | 0.5978493690490723 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q162606 |
| concepts[3].display_name | Endocrinology |
| concepts[4].id | https://openalex.org/C71924100 |
| concepts[4].level | 0 |
| concepts[4].score | 0.5836189389228821 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[4].display_name | Medicine |
| concepts[5].id | https://openalex.org/C511355011 |
| concepts[5].level | 2 |
| concepts[5].score | 0.549329936504364 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q12174 |
| concepts[5].display_name | Obesity |
| concepts[6].id | https://openalex.org/C2778754761 |
| concepts[6].level | 2 |
| concepts[6].score | 0.5213043093681335 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q421804 |
| concepts[6].display_name | Lipopolysaccharide |
| concepts[7].id | https://openalex.org/C20251656 |
| concepts[7].level | 3 |
| concepts[7].score | 0.45758146047592163 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q162643 |
| concepts[7].display_name | Glycolysis |
| concepts[8].id | https://openalex.org/C2780091579 |
| concepts[8].level | 2 |
| concepts[8].score | 0.4189158082008362 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q9377 |
| concepts[8].display_name | Kidney |
| concepts[9].id | https://openalex.org/C2781121325 |
| concepts[9].level | 4 |
| concepts[9].score | 0.4168641269207001 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q1146902 |
| concepts[9].display_name | Underweight |
| concepts[10].id | https://openalex.org/C62231903 |
| concepts[10].level | 2 |
| concepts[10].score | 0.3143972158432007 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q1057 |
| concepts[10].display_name | Metabolism |
| keywords[0].id | https://openalex.org/keywords/sepsis |
| keywords[0].score | 0.838583767414093 |
| keywords[0].display_name | Sepsis |
| keywords[1].id | https://openalex.org/keywords/overweight |
| keywords[1].score | 0.6662616729736328 |
| keywords[1].display_name | Overweight |
| keywords[2].id | https://openalex.org/keywords/internal-medicine |
| keywords[2].score | 0.6193833351135254 |
| keywords[2].display_name | Internal medicine |
| keywords[3].id | https://openalex.org/keywords/endocrinology |
| keywords[3].score | 0.5978493690490723 |
| keywords[3].display_name | Endocrinology |
| keywords[4].id | https://openalex.org/keywords/medicine |
| keywords[4].score | 0.5836189389228821 |
| keywords[4].display_name | Medicine |
| keywords[5].id | https://openalex.org/keywords/obesity |
| keywords[5].score | 0.549329936504364 |
| keywords[5].display_name | Obesity |
| keywords[6].id | https://openalex.org/keywords/lipopolysaccharide |
| keywords[6].score | 0.5213043093681335 |
| keywords[6].display_name | Lipopolysaccharide |
| keywords[7].id | https://openalex.org/keywords/glycolysis |
| keywords[7].score | 0.45758146047592163 |
| keywords[7].display_name | Glycolysis |
| keywords[8].id | https://openalex.org/keywords/kidney |
| keywords[8].score | 0.4189158082008362 |
| keywords[8].display_name | Kidney |
| keywords[9].id | https://openalex.org/keywords/underweight |
| keywords[9].score | 0.4168641269207001 |
| keywords[9].display_name | Underweight |
| keywords[10].id | https://openalex.org/keywords/metabolism |
| keywords[10].score | 0.3143972158432007 |
| keywords[10].display_name | Metabolism |
| language | en |
| locations[0].id | doi:10.1097/shk.0000000000001856 |
| locations[0].is_oa | False |
| locations[0].source.id | https://openalex.org/S174819509 |
| locations[0].source.issn | 1073-2322, 1540-0514 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | 1073-2322 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Shock |
| locations[0].source.host_organization | https://openalex.org/P4310315671 |
| locations[0].source.host_organization_name | Lippincott Williams & Wilkins |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310315671 |
| locations[0].license | |
| locations[0].pdf_url | |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Shock |
| locations[0].landing_page_url | https://doi.org/10.1097/shk.0000000000001856 |
| locations[1].id | pmid:34482320 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Shock (Augusta, Ga.) |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/34482320 |
| locations[2].id | pmh:oai:pubmedcentral.nih.gov:8678195 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S2764455111 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed Central |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Shock |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/8678195 |
| indexed_in | crossref, pubmed |
| authorships[0].author.id | https://openalex.org/A5089153232 |
| authorships[0].author.orcid | |
| authorships[0].author.display_name | Erick D. Lewis |
| authorships[0].affiliations[0].raw_affiliation_string | Aging and Critical Care Research Laboratory |
| authorships[0].affiliations[1].raw_affiliation_string | Department of Pharmacology and Nutritional Sciences |
| authorships[0].affiliations[2].raw_affiliation_string | Department of Surgery |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Erick D. Lewis |
| authorships[0].is_corresponding | True |
| authorships[0].raw_affiliation_strings | Aging and Critical Care Research Laboratory, Department of Pharmacology and Nutritional Sciences, Department of Surgery |
| authorships[1].author.id | https://openalex.org/A5040836772 |
| authorships[1].author.orcid | https://orcid.org/0000-0003-4041-5190 |
| authorships[1].author.display_name | Holden C. Williams |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Physiology |
| authorships[1].affiliations[1].raw_affiliation_string | Sanders Brown Center on Aging |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Holden C. Williams |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Physiology, Sanders Brown Center on Aging |
| authorships[2].author.id | https://openalex.org/A5111532410 |
| authorships[2].author.orcid | |
| authorships[2].author.display_name | Maria E. C. Bruno |
| authorships[2].affiliations[0].raw_affiliation_string | Aging and Critical Care Research Laboratory |
| authorships[2].affiliations[1].raw_affiliation_string | Department of Surgery |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Maria E.C. Bruno |
| authorships[2].is_corresponding | True |
| authorships[2].raw_affiliation_strings | Aging and Critical Care Research Laboratory, Department of Surgery |
| authorships[3].author.id | https://openalex.org/A5067935460 |
| authorships[3].author.orcid | https://orcid.org/0000-0003-0336-9789 |
| authorships[3].author.display_name | Arnold J. Stromberg |
| authorships[3].countries | US |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I143302722 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Statistics, University of Kentucky, Lexington, Kentucky |
| authorships[3].institutions[0].id | https://openalex.org/I143302722 |
| authorships[3].institutions[0].ror | https://ror.org/02k3smh20 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I143302722 |
| authorships[3].institutions[0].country_code | US |
| authorships[3].institutions[0].display_name | University of Kentucky |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Arnold J. Stromberg |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Statistics, University of Kentucky, Lexington, Kentucky |
| authorships[4].author.id | https://openalex.org/A5018970596 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-5845-5177 |
| authorships[4].author.display_name | Hiroshi Saitō |
| authorships[4].affiliations[0].raw_affiliation_string | Aging and Critical Care Research Laboratory |
| authorships[4].affiliations[1].raw_affiliation_string | Department of Physiology |
| authorships[4].affiliations[2].raw_affiliation_string | Department of Surgery |
| authorships[4].affiliations[3].raw_affiliation_string | Department of Pharmacology and Nutritional Sciences |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Hiroshi Saito |
| authorships[4].is_corresponding | True |
| authorships[4].raw_affiliation_strings | Aging and Critical Care Research Laboratory, Department of Pharmacology and Nutritional Sciences, Department of Physiology, Department of Surgery |
| authorships[5].author.id | https://openalex.org/A5020353300 |
| authorships[5].author.orcid | https://orcid.org/0000-0003-0134-7586 |
| authorships[5].author.display_name | Lance A. Johnson |
| authorships[5].affiliations[0].raw_affiliation_string | Department of Physiology |
| authorships[5].affiliations[1].raw_affiliation_string | Sanders Brown Center on Aging |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Lance A. Johnson |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Department of Physiology, Sanders Brown Center on Aging |
| authorships[6].author.id | https://openalex.org/A5072669719 |
| authorships[6].author.orcid | https://orcid.org/0000-0003-0304-348X |
| authorships[6].author.display_name | Marlene E. Starr |
| authorships[6].affiliations[0].raw_affiliation_string | Aging and Critical Care Research Laboratory |
| authorships[6].affiliations[1].raw_affiliation_string | Department of Pharmacology and Nutritional Sciences |
| authorships[6].affiliations[2].raw_affiliation_string | Department of Surgery |
| authorships[6].author_position | last |
| authorships[6].raw_author_name | Marlene E. Starr |
| authorships[6].is_corresponding | True |
| authorships[6].raw_affiliation_strings | Aging and Critical Care Research Laboratory, Department of Pharmacology and Nutritional Sciences, Department of Surgery |
| has_content.pdf | False |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.ncbi.nlm.nih.gov/pmc/articles/8678195 |
| open_access.oa_status | green |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Exploring the Obesity Paradox in A Murine Model of Sepsis: Improved Survival Despite Increased Organ Injury in Obese Mice |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10218 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9994000196456909 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2713 |
| primary_topic.subfield.display_name | Epidemiology |
| primary_topic.display_name | Sepsis Diagnosis and Treatment |
| related_works | https://openalex.org/W1897789714, https://openalex.org/W2520113602, https://openalex.org/W130814904, https://openalex.org/W2103497017, https://openalex.org/W2054438685, https://openalex.org/W2911488237, https://openalex.org/W798735226, https://openalex.org/W2166137611, https://openalex.org/W2411918094, https://openalex.org/W2131335005 |
| cited_by_count | 18 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 6 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 8 |
| counts_by_year[2].year | 2023 |
| counts_by_year[2].cited_by_count | 3 |
| counts_by_year[3].year | 2022 |
| counts_by_year[3].cited_by_count | 1 |
| locations_count | 3 |
| best_oa_location.id | pmh:oai:pubmedcentral.nih.gov:8678195 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S2764455111 |
| best_oa_location.source.issn | |
| best_oa_location.source.type | repository |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | |
| best_oa_location.source.is_core | False |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | PubMed Central |
| best_oa_location.source.host_organization | https://openalex.org/I1299303238 |
| best_oa_location.source.host_organization_name | National Institutes of Health |
| best_oa_location.source.host_organization_lineage | https://openalex.org/I1299303238 |
| best_oa_location.license | |
| best_oa_location.pdf_url | |
| best_oa_location.version | submittedVersion |
| best_oa_location.raw_type | Text |
| best_oa_location.license_id | |
| best_oa_location.is_accepted | False |
| best_oa_location.is_published | False |
| best_oa_location.raw_source_name | Shock |
| best_oa_location.landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/8678195 |
| primary_location.id | doi:10.1097/shk.0000000000001856 |
| primary_location.is_oa | False |
| primary_location.source.id | https://openalex.org/S174819509 |
| primary_location.source.issn | 1073-2322, 1540-0514 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | 1073-2322 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Shock |
| primary_location.source.host_organization | https://openalex.org/P4310315671 |
| primary_location.source.host_organization_name | Lippincott Williams & Wilkins |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310315671 |
| primary_location.license | |
| primary_location.pdf_url | |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Shock |
| primary_location.landing_page_url | https://doi.org/10.1097/shk.0000000000001856 |
| publication_date | 2021-09-02 |
| publication_year | 2021 |
| referenced_works | https://openalex.org/W2434130898, https://openalex.org/W2917899198, https://openalex.org/W2966430827, https://openalex.org/W2750649714, https://openalex.org/W3036473016, https://openalex.org/W2155045604, https://openalex.org/W2766859521, https://openalex.org/W3006332394, https://openalex.org/W3007830152, https://openalex.org/W2176413389, https://openalex.org/W2029334399, https://openalex.org/W2028662660, https://openalex.org/W2397668597, https://openalex.org/W2104328396, https://openalex.org/W2282178002, https://openalex.org/W2508427990, https://openalex.org/W2613377490, https://openalex.org/W2490099107, https://openalex.org/W2549474173, https://openalex.org/W2091648834, https://openalex.org/W3111323821, https://openalex.org/W1549912426, https://openalex.org/W2341031032, https://openalex.org/W2153615428, https://openalex.org/W2019402080, https://openalex.org/W2022243058, https://openalex.org/W2095465485, https://openalex.org/W3025458562, https://openalex.org/W2967129168, https://openalex.org/W2019646767, https://openalex.org/W4230798557, https://openalex.org/W2030630676, https://openalex.org/W2908147050, https://openalex.org/W2419143979, https://openalex.org/W2823725159, https://openalex.org/W2107117184, https://openalex.org/W2091503832, https://openalex.org/W6982587578, https://openalex.org/W2047286568, https://openalex.org/W4211084754, https://openalex.org/W6808231946, https://openalex.org/W2924371229, https://openalex.org/W2078226622, https://openalex.org/W2178272958, https://openalex.org/W2980178873, https://openalex.org/W2991104180, https://openalex.org/W2515730750, https://openalex.org/W2145053281 |
| referenced_works_count | 48 |
| abstract_inverted_index.6 | 168 |
| abstract_inverted_index.= | 111 |
| abstract_inverted_index.P | 110 |
| abstract_inverted_index.a | 28, 62, 216, 256 |
| abstract_inverted_index.h | 148, 171 |
| abstract_inverted_index.12 | 170 |
| abstract_inverted_index.14 | 116 |
| abstract_inverted_index.20 | 87 |
| abstract_inverted_index.24 | 147 |
| abstract_inverted_index.CS | 105 |
| abstract_inverted_index.at | 222 |
| abstract_inverted_index.be | 244 |
| abstract_inverted_index.by | 104 |
| abstract_inverted_index.in | 61, 156, 219, 234, 252 |
| abstract_inverted_index.of | 6, 19, 49, 57, 65, 94, 127, 134, 139, 179, 185, 225 |
| abstract_inverted_index.or | 13, 82 |
| abstract_inverted_index.to | 23, 43, 53, 97, 243, 246, 259 |
| abstract_inverted_index.TCA | 205 |
| abstract_inverted_index.The | 47, 230 |
| abstract_inverted_index.and | 25, 131, 143, 169, 197 |
| abstract_inverted_index.are | 255 |
| abstract_inverted_index.for | 86, 115 |
| abstract_inverted_index.had | 124 |
| abstract_inverted_index.not | 40 |
| abstract_inverted_index.the | 2, 31, 55, 58, 119, 204, 223, 235 |
| abstract_inverted_index.vs. | 108 |
| abstract_inverted_index.was | 52, 153 |
| abstract_inverted_index.(66% | 107 |
| abstract_inverted_index.25%, | 109 |
| abstract_inverted_index.Male | 75 |
| abstract_inverted_index.This | 207 |
| abstract_inverted_index.able | 42 |
| abstract_inverted_index.been | 41 |
| abstract_inverted_index.data | 9, 212 |
| abstract_inverted_index.from | 35 |
| abstract_inverted_index.have | 39 |
| abstract_inverted_index.into | 203 |
| abstract_inverted_index.mice | 77, 90, 99, 123, 161, 165, 192, 199 |
| abstract_inverted_index.more | 226 |
| abstract_inverted_index.test | 54 |
| abstract_inverted_index.that | 11, 213 |
| abstract_inverted_index.this | 50, 240, 249, 261 |
| abstract_inverted_index.were | 78, 145, 166 |
| abstract_inverted_index.with | 70, 190 |
| abstract_inverted_index.(HFD) | 81 |
| abstract_inverted_index.(LFD) | 84 |
| abstract_inverted_index.0.01, | 112 |
| abstract_inverted_index.IL-23 | 144 |
| abstract_inverted_index.IL-6, | 140 |
| abstract_inverted_index.While | 159 |
| abstract_inverted_index.after | 100, 149, 172 |
| abstract_inverted_index.begin | 247 |
| abstract_inverted_index.cecal | 66 |
| abstract_inverted_index.diets | 85 |
| abstract_inverted_index.entry | 202 |
| abstract_inverted_index.known | 3 |
| abstract_inverted_index.liver | 180 |
| abstract_inverted_index.mice. | 74, 158 |
| abstract_inverted_index.model | 64, 241 |
| abstract_inverted_index.novel | 257 |
| abstract_inverted_index.obese | 14, 73, 236 |
| abstract_inverted_index.organ | 228 |
| abstract_inverted_index.rates | 18, 93, 126 |
| abstract_inverted_index.study | 51, 209 |
| abstract_inverted_index.these | 45 |
| abstract_inverted_index.IL-17A | 152 |
| abstract_inverted_index.Stable | 174 |
| abstract_inverted_index.TNFα, | 142 |
| abstract_inverted_index.albeit | 221 |
| abstract_inverted_index.called | 30 |
| abstract_inverted_index.cycle. | 206 |
| abstract_inverted_index.days). | 117 |
| abstract_inverted_index.during | 188 |
| abstract_inverted_index.higher | 17, 92, 125 |
| abstract_inverted_index.kidney | 135 |
| abstract_inverted_index.levels | 138 |
| abstract_inverted_index.murine | 63, 208 |
| abstract_inverted_index.normal | 24 |
| abstract_inverted_index.remain | 237 |
| abstract_inverted_index.sepsis | 20, 37, 69 |
| abstract_inverted_index.septic | 101 |
| abstract_inverted_index.showed | 182 |
| abstract_inverted_index.slurry | 67 |
| abstract_inverted_index.target | 258 |
| abstract_inverted_index.tissue | 181 |
| abstract_inverted_index.weeks. | 88 |
| abstract_inverted_index.C57BL/6 | 76 |
| abstract_inverted_index.Despite | 1, 118 |
| abstract_inverted_index.HFD-fed | 89, 122, 157, 164, 198 |
| abstract_inverted_index.IL-1β, | 141 |
| abstract_inverted_index.LFD-fed | 98, 160, 191 |
| abstract_inverted_index.Results | 34 |
| abstract_inverted_index.appears | 242 |
| abstract_inverted_index.benefit | 218 |
| abstract_inverted_index.confers | 215 |
| abstract_inverted_index.effects | 5 |
| abstract_inverted_index.expense | 224 |
| abstract_inverted_index.glucose | 186, 201, 253 |
| abstract_inverted_index.induced | 103 |
| abstract_inverted_index.injury. | 136, 229 |
| abstract_inverted_index.isotope | 175 |
| abstract_inverted_index.low-fat | 83 |
| abstract_inverted_index.markers | 133 |
| abstract_inverted_index.obesity | 32, 59, 214 |
| abstract_inverted_index.paradox | 60 |
| abstract_inverted_index.sepsis, | 189, 220 |
| abstract_inverted_index.studies | 38 |
| abstract_inverted_index.ABSTRACT | 0 |
| abstract_inverted_index.activity | 196 |
| abstract_inverted_index.analysis | 178 |
| abstract_inverted_index.assessed | 114 |
| abstract_inverted_index.clinical | 8, 211 |
| abstract_inverted_index.compared | 22, 96 |
| abstract_inverted_index.cultures | 130 |
| abstract_inverted_index.high-fat | 80 |
| abstract_inverted_index.however, | 151, 239 |
| abstract_inverted_index.indicate | 10 |
| abstract_inverted_index.obesity, | 7 |
| abstract_inverted_index.paradox. | 33, 262 |
| abstract_inverted_index.pathways | 184 |
| abstract_inverted_index.patients | 15 |
| abstract_inverted_index.positive | 128 |
| abstract_inverted_index.provided | 79 |
| abstract_inverted_index.resolved | 176 |
| abstract_inverted_index.survival | 21, 95, 113, 120, 217, 233 |
| abstract_inverted_index.uniquely | 154 |
| abstract_inverted_index.unknown; | 238 |
| abstract_inverted_index.answering | 248 |
| abstract_inverted_index.bacterial | 129 |
| abstract_inverted_index.challenge | 102 |
| abstract_inverted_index.diverging | 183 |
| abstract_inverted_index.existence | 56 |
| abstract_inverted_index.findings. | 46 |
| abstract_inverted_index.increased | 132, 155 |
| abstract_inverted_index.injection | 106 |
| abstract_inverted_index.objective | 48 |
| abstract_inverted_index.patients; | 27 |
| abstract_inverted_index.promoting | 232 |
| abstract_inverted_index.question. | 250 |
| abstract_inverted_index.replicate | 44 |
| abstract_inverted_index.advantage, | 121 |
| abstract_inverted_index.decreasing | 200 |
| abstract_inverted_index.equivalent | 146 |
| abstract_inverted_index.experience | 16 |
| abstract_inverted_index.glycolytic | 195 |
| abstract_inverted_index.maintained | 162 |
| abstract_inverted_index.mechanisms | 231 |
| abstract_inverted_index.overweight | 12 |
| abstract_inverted_index.phenomenon | 29 |
| abstract_inverted_index.Circulating | 137 |
| abstract_inverted_index.Differences | 251 |
| abstract_inverted_index.deleterious | 4 |
| abstract_inverted_index.euglycemia, | 163 |
| abstract_inverted_index.experienced | 91 |
| abstract_inverted_index.investigate | 260 |
| abstract_inverted_index.preclinical | 36 |
| abstract_inverted_index.significant | 227 |
| abstract_inverted_index.underweight | 26 |
| abstract_inverted_index.utilization | 187, 254 |
| abstract_inverted_index.well-poised | 245 |
| abstract_inverted_index.(CS)-induced | 68 |
| abstract_inverted_index.corroborates | 210 |
| abstract_inverted_index.diet-induced | 72 |
| abstract_inverted_index.metabolomics | 177 |
| abstract_inverted_index.upregulating | 194 |
| abstract_inverted_index.CS-injection. | 173 |
| abstract_inverted_index.CS-injection; | 150 |
| abstract_inverted_index.hyperglycemic | 167 |
| abstract_inverted_index.significantly | 193 |
| abstract_inverted_index.insulin-resistant | 71 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 89 |
| corresponding_author_ids | https://openalex.org/A5072669719, https://openalex.org/A5089153232, https://openalex.org/A5111532410, https://openalex.org/A5018970596 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 7 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.7400000095367432 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.85791253 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |