Exploring the Pharmacokinetics of Drugs in Disabled Saudi Patients: A Systematic Review Article Swipe
Faleh Alqahtani
,
Saeed A. Al Awadh
,
Muhammad Fawad Rasool
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/ph18040582
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/ph18040582
Background/Objectives: Disability is a term that involves mental, intellectual, or sensory impairment resulting in the loss of one’s ability to walk or perform the activities necessary to live in a society. This study aims to collect all the data regarding the absorption, distribution, and disposition of drugs in disabled Saudi patients, i.e., patients suffering from epilepsy, cancer, cardiovascular diseases, etc., and then compare these results with data reported in other ethnicities. Methods: An exhaustive online search used the key terms in Google Scholar, PubMed, Cochrane Library, and Science Direct to extract all articles that met the eligibility criteria. All research studies containing pharmacokinetic (PK) parameters (area under the curve from 0 to infinity (AUC0–∞), maximal plasma concentration (Cmax), clearance (CL), volume of distribution, time to reach maximum plasma concentration, and half-life) were included in this review. Results: In pediatric epileptic patients, carbamazepine showed a notable decrease in Cmax with increasing age, which may be due to ontogenetic changes in its disposition. The AUC0–∞ of busulphan in adult hematopoietic stem cell transplantation patients was recorded as 4392.5 ± 1354.65 μg·h/mL, with high inter-individual variability. Moreover, the CL of vancomycin was reported to be 25% higher among cancer patients in comparison to non-cancer subjects. Conclusions: The complications in disabled patients due to alterations in cytochrome P450 enzymes, pathophysiology, genetics, and ethnicity emphasize the significance of patient-centered drug dosing. These findings may aid healthcare physicians in refining therapeutic care in this population.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3390/ph18040582
- https://www.mdpi.com/1424-8247/18/4/582/pdf?version=1744806804
- OA Status
- gold
- References
- 47
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4409503210
All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4409503210Canonical identifier for this work in OpenAlex
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https://doi.org/10.3390/ph18040582Digital Object Identifier
- Title
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Exploring the Pharmacokinetics of Drugs in Disabled Saudi Patients: A Systematic ReviewWork title
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reviewOpenAlex work type
- Language
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enPrimary language
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2025Year of publication
- Publication date
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2025-04-16Full publication date if available
- Authors
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Faleh Alqahtani, Saeed A. Al Awadh, Muhammad Fawad RasoolList of authors in order
- Landing page
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https://doi.org/10.3390/ph18040582Publisher landing page
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https://www.mdpi.com/1424-8247/18/4/582/pdf?version=1744806804Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.mdpi.com/1424-8247/18/4/582/pdf?version=1744806804Direct OA link when available
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Cmax, Medicine, Pharmacokinetics, Population, Dosing, Ethnic group, Cancer, Volume of distribution, Pharmacology, Oncology, Internal medicine, Sociology, Anthropology, Environmental healthTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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47Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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