Exploring the Potential of Phytocannabinoids Against Multidrug-Resistant Bacteria Article Swipe
Carmina Sirignano
,
Simona De Vita
,
Ernesto Gargiulo
,
Massimiliano Lucidi
,
Daniela Visaggio
,
Maria Giovanna Chini
,
Gianluigi Lauro
,
Giuseppina Chianese
,
Paolo Visca
,
Gennaro Nicola Bifulco
,
Orazio Taglialatela‐Scafati
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/plants14131901
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/plants14131901
The rapid emergence of multidrug-resistant (MDR) bacterial pathogens poses a critical threat to global health, creating an urgent need for novel antimicrobial agents. In this study, we evaluated a small library of natural and semisynthetic phytocannabinoids against a broad panel of MDR Gram-positive bacterial strains, evidencing very good activity in the low µM range. We provide evidence of the antibacterial activity of the two separated enantiomers of cannabidiol, offering novel insights into the stereochemical aspects of their bioactivity. To investigate the possible molecular targets and clarify the mechanism of action, we employed Inverse Virtual Screening (IVS), a computational approach optimized for predicting potential protein–ligand interactions, on three selected MDR bacterial species. Interestingly, key targets belonging to important bacterial metabolic pathways and defense mechanisms were retrieved, and the results were used to rationalize the observed biological activities. To the best of our knowledge, this study marks the first application of IVS to microorganisms, offering a novel strategy for identifying bacterial protein targets. The results pave the way for future experimental validation, structure-based drug design, and the development of novel antibacterial agents.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/plants14131901
- https://www.mdpi.com/2223-7747/14/13/1901/pdf?version=1750423033
- OA Status
- gold
- References
- 64
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4411491458
All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4411491458Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/plants14131901Digital Object Identifier
- Title
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Exploring the Potential of Phytocannabinoids Against Multidrug-Resistant BacteriaWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-06-20Full publication date if available
- Authors
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Carmina Sirignano, Simona De Vita, Ernesto Gargiulo, Massimiliano Lucidi, Daniela Visaggio, Maria Giovanna Chini, Gianluigi Lauro, Giuseppina Chianese, Paolo Visca, Gennaro Nicola Bifulco, Orazio Taglialatela‐ScafatiList of authors in order
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https://doi.org/10.3390/plants14131901Publisher landing page
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https://www.mdpi.com/2223-7747/14/13/1901/pdf?version=1750423033Direct link to full text PDF
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://www.mdpi.com/2223-7747/14/13/1901/pdf?version=1750423033Direct OA link when available
- Concepts
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Multiple drug resistance, Bacteria, Microbiology, Chemistry, Antibiotics, Biology, GeneticsTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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64Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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