Exploring the relationship between cycle threshold values and oral manifestations in COVID-19: a comprehensive overview Article Swipe
Dalit Porat Ben Amy
,
Hanan Rohana
,
Maya Azrad
,
Michael V. Joachim
,
Ori Bar
,
Imad Abu El‐Naaj
,
Avi Peretz
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.2340/aos.v83.41390
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.2340/aos.v83.41390
Objective: This cross-sectional study aimed to compare oral manifestations between severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-positive and SARS-CoV-2-negative patients and to examine associations between oral symptoms, Ct values of E and N SARS-CoV-2 viral genes, and the implications of low Ct values indicating a high viral load, which is a predictive factor for the outcome of COVID-19. Methods: A total of 353 participating patients were aged ≥18 years with clinical manifestations of COVID-19 infection and tested for SARS-CoV-2 carriage at the medical center, by reverse transcriptase polymerase chain reaction (RT-PCR). All patients filled out an anonymous digital questionnaire regarding oral and general symptoms and overall medical health. Results: A significant association was found between SARS-CoV-2 carriage and dry mouth, unpleasant taste and changes in taste (p < 0.001); for example, 37.4% of the 147 SARS-CoV-2- positive participants had a dry mouth, compared to 18.9% of the 206 SARS-CoV-2- negative participants. Oral blisters were experienced by patients with an E gene Ct value of 10–20 (50%) or 21–30 (50%) (p = 0.041). Bad breath, dry mouth, unpleasant taste and changes in taste were mostly present in participants whose Ct values of both E and N genes were between 21 and 30. Conclusions: This study found significant associations between low Ct values of E and N SARS-CoV-2 viral genes and high viral load, indicating that Ct values can serve as predictive factors for COVID-19 outcomes. The findings suggest that while oral symptoms are present, the Ct values and associated high viral loads are more critical indicators of disease severity and prognosis.
Related Topics
Concepts
Coronavirus disease 2019 (COVID-19)
2019-20 coronavirus outbreak
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Medicine
Virology
Internal medicine
Outbreak
Disease
Infectious disease (medical specialty)
Metadata
- Type
- article
- Language
- en
- Landing Page
- http://doi.org/10.2340/aos.v83.41390
- OA Status
- diamond
- References
- 21
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4402732161
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4402732161Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.2340/aos.v83.41390Digital Object Identifier
- Title
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Exploring the relationship between cycle threshold values and oral manifestations in COVID-19: a comprehensive overviewWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-09-23Full publication date if available
- Authors
-
Dalit Porat Ben Amy, Hanan Rohana, Maya Azrad, Michael V. Joachim, Ori Bar, Imad Abu El‐Naaj, Avi PeretzList of authors in order
- Landing page
-
https://doi.org/10.2340/aos.v83.41390Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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diamondOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.2340/aos.v83.41390Direct OA link when available
- Concepts
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Coronavirus disease 2019 (COVID-19), 2019-20 coronavirus outbreak, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Medicine, Virology, Internal medicine, Outbreak, Disease, Infectious disease (medical specialty)Top concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- References (count)
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21Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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