Exploring the role of exosomes in diabetic neuropathy: From molecular mechanisms to therapeutic potential Article Swipe
Zohreh Tajabadi
,
Parisa Alsadat Dadkhah
,
Mohammad Sadra Gholami Chahkand
,
Fatemeh Esmaeilpour Moallem
,
Mohammad Amin Karimi
,
Ehsan Amini‐Salehi
,
Mehdi Karimi
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1016/j.biopha.2025.117959
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1016/j.biopha.2025.117959
Diabetic neuropathy (DN) is a debilitating complication of diabetes mellitus (DM), characterized by progressive neuronal damage, sensory dysfunction, and impaired quality of life. Recent advances in exosome research have elucidated their crucial role in DN's pathogenesis, diagnosis, and treatment. Exosomes-nanoscale extracellular vesicles-function as vehicles for molecular cargo, including microRNAs (miRNAs), proteins, and lipids, which mediate intercellular communication and regulate key biological processes. Pathologically, hyperglycemia and hyperlipidemia induce the release of exosomes enriched with pathogenic miRNAs, such as miR-130a and miR-20b-3p, which disrupt neuronal function, axonal regeneration, and inflammatory pathways. Conversely, diagnostic studies highlight the utility of exosomal biomarkers like miR-7 and miR-221 in the early detection and monitoring of DN. Therapeutically, Schwann cell-derived and mesenchymal stromal cell (MSC)-derived exosomes demonstrate neuroprotective and reparative effects by enhancing mitochondrial function, modulating inflammation, and promoting axonal repair. Emerging approaches, including engineered exosomes and miRNA-enriched vesicles, further expand their therapeutic potential. Despite these advances, challenges such as standardization, large-scale production, and clinical validation remain in translating these findings into clinical practice. This review underscores the multifaceted roles of exosomes in DN and highlights their potential as innovative tools for precision diagnostics and targeted therapies, paving the way for future research and clinical applications.
Related Topics
Concepts
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.biopha.2025.117959
- OA Status
- gold
- Cited By
- 6
- References
- 92
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4408254582
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4408254582Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1016/j.biopha.2025.117959Digital Object Identifier
- Title
-
Exploring the role of exosomes in diabetic neuropathy: From molecular mechanisms to therapeutic potentialWork title
- Type
-
reviewOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-03-08Full publication date if available
- Authors
-
Zohreh Tajabadi, Parisa Alsadat Dadkhah, Mohammad Sadra Gholami Chahkand, Fatemeh Esmaeilpour Moallem, Mohammad Amin Karimi, Ehsan Amini‐Salehi, Mehdi KarimiList of authors in order
- Landing page
-
https://doi.org/10.1016/j.biopha.2025.117959Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1016/j.biopha.2025.117959Direct OA link when available
- Concepts
-
Microvesicles, Diabetic neuropathy, Medicine, Diabetes mellitus, Bioinformatics, Pharmacology, Cancer research, Endocrinology, microRNA, Biology, Genetics, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
6Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 6Per-year citation counts (last 5 years)
- References (count)
-
92Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4408254582 |
|---|---|
| doi | https://doi.org/10.1016/j.biopha.2025.117959 |
| ids.doi | https://doi.org/10.1016/j.biopha.2025.117959 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/40056828 |
| ids.openalex | https://openalex.org/W4408254582 |
| fwci | 16.09766777 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D006801 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Humans |
| mesh[1].qualifier_ui | Q000378 |
| mesh[1].descriptor_ui | D055354 |
| mesh[1].is_major_topic | True |
| mesh[1].qualifier_name | metabolism |
| mesh[1].descriptor_name | Exosomes |
| mesh[2].qualifier_ui | Q000628 |
| mesh[2].descriptor_ui | D003929 |
| mesh[2].is_major_topic | True |
| mesh[2].qualifier_name | therapy |
| mesh[2].descriptor_name | Diabetic Neuropathies |
| mesh[3].qualifier_ui | Q000378 |
| mesh[3].descriptor_ui | D003929 |
| mesh[3].is_major_topic | True |
| mesh[3].qualifier_name | metabolism |
| mesh[3].descriptor_name | Diabetic Neuropathies |
| mesh[4].qualifier_ui | Q000235 |
| mesh[4].descriptor_ui | D003929 |
| mesh[4].is_major_topic | True |
| mesh[4].qualifier_name | genetics |
| mesh[4].descriptor_name | Diabetic Neuropathies |
| mesh[5].qualifier_ui | |
| mesh[5].descriptor_ui | D000818 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | |
| mesh[5].descriptor_name | Animals |
| mesh[6].qualifier_ui | Q000378 |
| mesh[6].descriptor_ui | D035683 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | metabolism |
| mesh[6].descriptor_name | MicroRNAs |
| mesh[7].qualifier_ui | Q000235 |
| mesh[7].descriptor_ui | D035683 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | genetics |
| mesh[7].descriptor_name | MicroRNAs |
| mesh[8].qualifier_ui | |
| mesh[8].descriptor_ui | D006801 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | |
| mesh[8].descriptor_name | Humans |
| mesh[9].qualifier_ui | Q000378 |
| mesh[9].descriptor_ui | D055354 |
| mesh[9].is_major_topic | True |
| mesh[9].qualifier_name | metabolism |
| mesh[9].descriptor_name | Exosomes |
| mesh[10].qualifier_ui | Q000628 |
| mesh[10].descriptor_ui | D003929 |
| mesh[10].is_major_topic | True |
| mesh[10].qualifier_name | therapy |
| mesh[10].descriptor_name | Diabetic Neuropathies |
| mesh[11].qualifier_ui | Q000378 |
| mesh[11].descriptor_ui | D003929 |
| mesh[11].is_major_topic | True |
| mesh[11].qualifier_name | metabolism |
| mesh[11].descriptor_name | Diabetic Neuropathies |
| mesh[12].qualifier_ui | |
| mesh[12].descriptor_ui | D000818 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | |
| mesh[12].descriptor_name | Animals |
| mesh[13].qualifier_ui | Q000235 |
| mesh[13].descriptor_ui | D035683 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | genetics |
| mesh[13].descriptor_name | MicroRNAs |
| mesh[14].qualifier_ui | Q000378 |
| mesh[14].descriptor_ui | D035683 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | metabolism |
| mesh[14].descriptor_name | MicroRNAs |
| mesh[15].qualifier_ui | Q000378 |
| mesh[15].descriptor_ui | D015415 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | metabolism |
| mesh[15].descriptor_name | Biomarkers |
| mesh[16].qualifier_ui | |
| mesh[16].descriptor_ui | D006801 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | |
| mesh[16].descriptor_name | Humans |
| mesh[17].qualifier_ui | Q000378 |
| mesh[17].descriptor_ui | D055354 |
| mesh[17].is_major_topic | True |
| mesh[17].qualifier_name | metabolism |
| mesh[17].descriptor_name | Exosomes |
| mesh[18].qualifier_ui | Q000628 |
| mesh[18].descriptor_ui | D003929 |
| mesh[18].is_major_topic | True |
| mesh[18].qualifier_name | therapy |
| mesh[18].descriptor_name | Diabetic Neuropathies |
| mesh[19].qualifier_ui | Q000378 |
| mesh[19].descriptor_ui | D003929 |
| mesh[19].is_major_topic | True |
| mesh[19].qualifier_name | metabolism |
| mesh[19].descriptor_name | Diabetic Neuropathies |
| mesh[20].qualifier_ui | Q000235 |
| mesh[20].descriptor_ui | D003929 |
| mesh[20].is_major_topic | True |
| mesh[20].qualifier_name | genetics |
| mesh[20].descriptor_name | Diabetic Neuropathies |
| mesh[21].qualifier_ui | |
| mesh[21].descriptor_ui | D000818 |
| mesh[21].is_major_topic | False |
| mesh[21].qualifier_name | |
| mesh[21].descriptor_name | Animals |
| mesh[22].qualifier_ui | Q000378 |
| mesh[22].descriptor_ui | D035683 |
| mesh[22].is_major_topic | False |
| mesh[22].qualifier_name | metabolism |
| mesh[22].descriptor_name | MicroRNAs |
| mesh[23].qualifier_ui | Q000235 |
| mesh[23].descriptor_ui | D035683 |
| mesh[23].is_major_topic | False |
| mesh[23].qualifier_name | genetics |
| mesh[23].descriptor_name | MicroRNAs |
| type | review |
| title | Exploring the role of exosomes in diabetic neuropathy: From molecular mechanisms to therapeutic potential |
| biblio.issue | |
| biblio.volume | 185 |
| biblio.last_page | 117959 |
| biblio.first_page | 117959 |
| topics[0].id | https://openalex.org/T10773 |
| topics[0].field.id | https://openalex.org/fields/13 |
| topics[0].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[0].score | 1.0 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1312 |
| topics[0].subfield.display_name | Molecular Biology |
| topics[0].display_name | Extracellular vesicles in disease |
| topics[1].id | https://openalex.org/T10725 |
| topics[1].field.id | https://openalex.org/fields/13 |
| topics[1].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[1].score | 0.9740999937057495 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1312 |
| topics[1].subfield.display_name | Molecular Biology |
| topics[1].display_name | RNA Interference and Gene Delivery |
| topics[2].id | https://openalex.org/T12610 |
| topics[2].field.id | https://openalex.org/fields/13 |
| topics[2].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[2].score | 0.9671000242233276 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/1312 |
| topics[2].subfield.display_name | Molecular Biology |
| topics[2].display_name | RNA regulation and disease |
| is_xpac | False |
| apc_list.value | 2660 |
| apc_list.currency | USD |
| apc_list.value_usd | 2660 |
| apc_paid.value | 2660 |
| apc_paid.currency | USD |
| apc_paid.value_usd | 2660 |
| concepts[0].id | https://openalex.org/C20518536 |
| concepts[0].level | 4 |
| concepts[0].score | 0.7918245196342468 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q6840469 |
| concepts[0].display_name | Microvesicles |
| concepts[1].id | https://openalex.org/C2779178840 |
| concepts[1].level | 3 |
| concepts[1].score | 0.7189261317253113 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q2046550 |
| concepts[1].display_name | Diabetic neuropathy |
| concepts[2].id | https://openalex.org/C71924100 |
| concepts[2].level | 0 |
| concepts[2].score | 0.5950360298156738 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[2].display_name | Medicine |
| concepts[3].id | https://openalex.org/C555293320 |
| concepts[3].level | 2 |
| concepts[3].score | 0.45163920521736145 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q12206 |
| concepts[3].display_name | Diabetes mellitus |
| concepts[4].id | https://openalex.org/C60644358 |
| concepts[4].level | 1 |
| concepts[4].score | 0.3768085539340973 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q128570 |
| concepts[4].display_name | Bioinformatics |
| concepts[5].id | https://openalex.org/C98274493 |
| concepts[5].level | 1 |
| concepts[5].score | 0.36641925573349 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q128406 |
| concepts[5].display_name | Pharmacology |
| concepts[6].id | https://openalex.org/C502942594 |
| concepts[6].level | 1 |
| concepts[6].score | 0.3293289542198181 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q3421914 |
| concepts[6].display_name | Cancer research |
| concepts[7].id | https://openalex.org/C134018914 |
| concepts[7].level | 1 |
| concepts[7].score | 0.20559433102607727 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q162606 |
| concepts[7].display_name | Endocrinology |
| concepts[8].id | https://openalex.org/C145059251 |
| concepts[8].level | 3 |
| concepts[8].score | 0.19255685806274414 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q310899 |
| concepts[8].display_name | microRNA |
| concepts[9].id | https://openalex.org/C86803240 |
| concepts[9].level | 0 |
| concepts[9].score | 0.17778801918029785 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[9].display_name | Biology |
| concepts[10].id | https://openalex.org/C54355233 |
| concepts[10].level | 1 |
| concepts[10].score | 0.10752829909324646 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q7162 |
| concepts[10].display_name | Genetics |
| concepts[11].id | https://openalex.org/C104317684 |
| concepts[11].level | 2 |
| concepts[11].score | 0.06875297427177429 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q7187 |
| concepts[11].display_name | Gene |
| keywords[0].id | https://openalex.org/keywords/microvesicles |
| keywords[0].score | 0.7918245196342468 |
| keywords[0].display_name | Microvesicles |
| keywords[1].id | https://openalex.org/keywords/diabetic-neuropathy |
| keywords[1].score | 0.7189261317253113 |
| keywords[1].display_name | Diabetic neuropathy |
| keywords[2].id | https://openalex.org/keywords/medicine |
| keywords[2].score | 0.5950360298156738 |
| keywords[2].display_name | Medicine |
| keywords[3].id | https://openalex.org/keywords/diabetes-mellitus |
| keywords[3].score | 0.45163920521736145 |
| keywords[3].display_name | Diabetes mellitus |
| keywords[4].id | https://openalex.org/keywords/bioinformatics |
| keywords[4].score | 0.3768085539340973 |
| keywords[4].display_name | Bioinformatics |
| keywords[5].id | https://openalex.org/keywords/pharmacology |
| keywords[5].score | 0.36641925573349 |
| keywords[5].display_name | Pharmacology |
| keywords[6].id | https://openalex.org/keywords/cancer-research |
| keywords[6].score | 0.3293289542198181 |
| keywords[6].display_name | Cancer research |
| keywords[7].id | https://openalex.org/keywords/endocrinology |
| keywords[7].score | 0.20559433102607727 |
| keywords[7].display_name | Endocrinology |
| keywords[8].id | https://openalex.org/keywords/microrna |
| keywords[8].score | 0.19255685806274414 |
| keywords[8].display_name | microRNA |
| keywords[9].id | https://openalex.org/keywords/biology |
| keywords[9].score | 0.17778801918029785 |
| keywords[9].display_name | Biology |
| keywords[10].id | https://openalex.org/keywords/genetics |
| keywords[10].score | 0.10752829909324646 |
| keywords[10].display_name | Genetics |
| keywords[11].id | https://openalex.org/keywords/gene |
| keywords[11].score | 0.06875297427177429 |
| keywords[11].display_name | Gene |
| language | en |
| locations[0].id | doi:10.1016/j.biopha.2025.117959 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S15111687 |
| locations[0].source.issn | 0753-3322, 1950-6007 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 0753-3322 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Biomedicine & Pharmacotherapy |
| locations[0].source.host_organization | https://openalex.org/P4310320990 |
| locations[0].source.host_organization_name | Elsevier BV |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320990 |
| locations[0].license | cc-by |
| locations[0].pdf_url | |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Biomedicine & Pharmacotherapy |
| locations[0].landing_page_url | https://doi.org/10.1016/j.biopha.2025.117959 |
| locations[1].id | pmid:40056828 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/40056828 |
| indexed_in | crossref, pubmed |
| authorships[0].author.id | https://openalex.org/A5014188095 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-9854-7260 |
| authorships[0].author.display_name | Zohreh Tajabadi |
| authorships[0].countries | IR |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I70640408 |
| authorships[0].affiliations[0].raw_affiliation_string | Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran. |
| authorships[0].institutions[0].id | https://openalex.org/I70640408 |
| authorships[0].institutions[0].ror | https://ror.org/01c4pz451 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I70640408 |
| authorships[0].institutions[0].country_code | IR |
| authorships[0].institutions[0].display_name | Tehran University of Medical Sciences |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Zohreh Tajabadi |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran. |
| authorships[1].author.id | https://openalex.org/A5026895645 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-4590-7525 |
| authorships[1].author.display_name | Parisa Alsadat Dadkhah |
| authorships[1].countries | IR |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I114982161 |
| authorships[1].affiliations[0].raw_affiliation_string | School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. |
| authorships[1].institutions[0].id | https://openalex.org/I114982161 |
| authorships[1].institutions[0].ror | https://ror.org/04waqzz56 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I114982161 |
| authorships[1].institutions[0].country_code | IR |
| authorships[1].institutions[0].display_name | Isfahan University of Medical Sciences |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Parisa Alsadat Dadkhah |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. |
| authorships[2].author.id | https://openalex.org/A5093378519 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-5710-2142 |
| authorships[2].author.display_name | Mohammad Sadra Gholami Chahkand |
| authorships[2].countries | IR |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I198873322, https://openalex.org/I4210127922 |
| authorships[2].affiliations[0].raw_affiliation_string | Student Research Committee, Golestan University of Medical Sciences, Gorgan, Iran. |
| authorships[2].institutions[0].id | https://openalex.org/I198873322 |
| authorships[2].institutions[0].ror | https://ror.org/046nf9z89 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I198873322 |
| authorships[2].institutions[0].country_code | IR |
| authorships[2].institutions[0].display_name | Golestan University |
| authorships[2].institutions[1].id | https://openalex.org/I4210127922 |
| authorships[2].institutions[1].ror | https://ror.org/03mcx2558 |
| authorships[2].institutions[1].type | education |
| authorships[2].institutions[1].lineage | https://openalex.org/I4210127922 |
| authorships[2].institutions[1].country_code | IR |
| authorships[2].institutions[1].display_name | Golestan University of Medical Sciences |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Mohammad Sadra Gholami Chahkand |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Student Research Committee, Golestan University of Medical Sciences, Gorgan, Iran. |
| authorships[3].author.id | https://openalex.org/A5093378521 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-2653-3978 |
| authorships[3].author.display_name | Fatemeh Esmaeilpour Moallem |
| authorships[3].countries | IR |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I198873322, https://openalex.org/I4210127922 |
| authorships[3].affiliations[0].raw_affiliation_string | Student Research Committee, Golestan University of Medical Sciences, Gorgan, Iran. |
| authorships[3].institutions[0].id | https://openalex.org/I198873322 |
| authorships[3].institutions[0].ror | https://ror.org/046nf9z89 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I198873322 |
| authorships[3].institutions[0].country_code | IR |
| authorships[3].institutions[0].display_name | Golestan University |
| authorships[3].institutions[1].id | https://openalex.org/I4210127922 |
| authorships[3].institutions[1].ror | https://ror.org/03mcx2558 |
| authorships[3].institutions[1].type | education |
| authorships[3].institutions[1].lineage | https://openalex.org/I4210127922 |
| authorships[3].institutions[1].country_code | IR |
| authorships[3].institutions[1].display_name | Golestan University of Medical Sciences |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Fatemeh Esmaeilpour Moallem |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Student Research Committee, Golestan University of Medical Sciences, Gorgan, Iran. |
| authorships[4].author.id | https://openalex.org/A5102486354 |
| authorships[4].author.orcid | |
| authorships[4].author.display_name | Mohammad Amin Karimi |
| authorships[4].countries | IR |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I58048189 |
| authorships[4].affiliations[0].raw_affiliation_string | School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: [email protected]. |
| authorships[4].institutions[0].id | https://openalex.org/I58048189 |
| authorships[4].institutions[0].ror | https://ror.org/034m2b326 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I58048189 |
| authorships[4].institutions[0].country_code | IR |
| authorships[4].institutions[0].display_name | Shahid Beheshti University of Medical Sciences |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Mohammad Amin Karimi |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: [email protected]. |
| authorships[5].author.id | https://openalex.org/A5046574915 |
| authorships[5].author.orcid | https://orcid.org/0000-0003-4985-2899 |
| authorships[5].author.display_name | Ehsan Amini‐Salehi |
| authorships[5].countries | IR |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I204331812 |
| authorships[5].affiliations[0].raw_affiliation_string | School of Medicine, Guilan University of Medical Sciences, Rasht, Iran. |
| authorships[5].institutions[0].id | https://openalex.org/I204331812 |
| authorships[5].institutions[0].ror | https://ror.org/04ptbrd12 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I204331812, https://openalex.org/I4210110574 |
| authorships[5].institutions[0].country_code | IR |
| authorships[5].institutions[0].display_name | Guilan University of Medical Sciences |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Ehsan Amini-Salehi |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | School of Medicine, Guilan University of Medical Sciences, Rasht, Iran. |
| authorships[6].author.id | https://openalex.org/A5110301001 |
| authorships[6].author.orcid | https://orcid.org/0009-0006-4388-0214 |
| authorships[6].author.display_name | Mehdi Karimi |
| authorships[6].countries | UA |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I84407627 |
| authorships[6].affiliations[0].raw_affiliation_string | Faculty of Medicine, Bogomolets National Medical University (NMU), Kyiv, Ukraine. |
| authorships[6].institutions[0].id | https://openalex.org/I84407627 |
| authorships[6].institutions[0].ror | https://ror.org/03edafd86 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I84407627 |
| authorships[6].institutions[0].country_code | UA |
| authorships[6].institutions[0].display_name | Bogomolets National Medical University |
| authorships[6].author_position | last |
| authorships[6].raw_author_name | Mehdi Karimi |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Faculty of Medicine, Bogomolets National Medical University (NMU), Kyiv, Ukraine. |
| has_content.pdf | False |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://doi.org/10.1016/j.biopha.2025.117959 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Exploring the role of exosomes in diabetic neuropathy: From molecular mechanisms to therapeutic potential |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10773 |
| primary_topic.field.id | https://openalex.org/fields/13 |
| primary_topic.field.display_name | Biochemistry, Genetics and Molecular Biology |
| primary_topic.score | 1.0 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1312 |
| primary_topic.subfield.display_name | Molecular Biology |
| primary_topic.display_name | Extracellular vesicles in disease |
| related_works | https://openalex.org/W4238390078, https://openalex.org/W2903989816, https://openalex.org/W1985945858, https://openalex.org/W4253711409, https://openalex.org/W2150281802, https://openalex.org/W2470671226, https://openalex.org/W3214468175, https://openalex.org/W1785326690, https://openalex.org/W27718370, https://openalex.org/W4285154983 |
| cited_by_count | 6 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 6 |
| locations_count | 2 |
| best_oa_location.id | doi:10.1016/j.biopha.2025.117959 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S15111687 |
| best_oa_location.source.issn | 0753-3322, 1950-6007 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 0753-3322 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | Biomedicine & Pharmacotherapy |
| best_oa_location.source.host_organization | https://openalex.org/P4310320990 |
| best_oa_location.source.host_organization_name | Elsevier BV |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320990 |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Biomedicine & Pharmacotherapy |
| best_oa_location.landing_page_url | https://doi.org/10.1016/j.biopha.2025.117959 |
| primary_location.id | doi:10.1016/j.biopha.2025.117959 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S15111687 |
| primary_location.source.issn | 0753-3322, 1950-6007 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 0753-3322 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Biomedicine & Pharmacotherapy |
| primary_location.source.host_organization | https://openalex.org/P4310320990 |
| primary_location.source.host_organization_name | Elsevier BV |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320990 |
| primary_location.license | cc-by |
| primary_location.pdf_url | |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Biomedicine & Pharmacotherapy |
| primary_location.landing_page_url | https://doi.org/10.1016/j.biopha.2025.117959 |
| publication_date | 2025-03-08 |
| publication_year | 2025 |
| referenced_works | https://openalex.org/W3039583507, https://openalex.org/W4384281875, https://openalex.org/W2983229458, https://openalex.org/W4221083072, https://openalex.org/W3177665306, https://openalex.org/W4296425676, https://openalex.org/W2999784269, https://openalex.org/W2101099639, https://openalex.org/W6860812956, https://openalex.org/W3136183120, https://openalex.org/W4212865003, https://openalex.org/W2056611380, https://openalex.org/W2987816669, https://openalex.org/W6871427405, https://openalex.org/W2914833536, https://openalex.org/W2175410088, https://openalex.org/W2919824502, https://openalex.org/W2889573274, https://openalex.org/W4290738879, https://openalex.org/W3179765947, https://openalex.org/W6807818645, https://openalex.org/W2799993759, https://openalex.org/W2139719728, https://openalex.org/W2597734448, https://openalex.org/W4319982696, https://openalex.org/W3165754381, https://openalex.org/W3116622518, https://openalex.org/W2066686707, https://openalex.org/W1978797498, https://openalex.org/W2287994218, https://openalex.org/W3098441039, https://openalex.org/W2007479707, https://openalex.org/W2063206709, https://openalex.org/W3159688403, https://openalex.org/W4281253361, https://openalex.org/W1831581079, https://openalex.org/W1631836261, https://openalex.org/W6802876403, https://openalex.org/W3024792050, https://openalex.org/W2331135699, https://openalex.org/W2581074366, https://openalex.org/W3210933063, https://openalex.org/W2071188263, https://openalex.org/W1915536483, https://openalex.org/W2782804476, https://openalex.org/W2903106788, https://openalex.org/W3005104290, https://openalex.org/W2738491178, https://openalex.org/W2786514708, https://openalex.org/W2098259366, https://openalex.org/W2109298880, https://openalex.org/W2904802348, https://openalex.org/W2900059354, https://openalex.org/W1832220924, https://openalex.org/W2912086514, https://openalex.org/W4388969698, https://openalex.org/W4403743498, https://openalex.org/W3033977711, https://openalex.org/W3018856165, https://openalex.org/W1938236935, https://openalex.org/W2808800485, https://openalex.org/W4390919553, https://openalex.org/W2622017122, https://openalex.org/W2520336210, https://openalex.org/W3161318391, https://openalex.org/W4280527205, https://openalex.org/W4386542042, https://openalex.org/W2987239393, https://openalex.org/W6802140779, https://openalex.org/W3158331929, https://openalex.org/W4312054038, https://openalex.org/W4327723634, https://openalex.org/W6864615487, https://openalex.org/W4402141151, https://openalex.org/W4316174706, https://openalex.org/W4210724818, https://openalex.org/W4404895308, https://openalex.org/W3200640616, https://openalex.org/W3004441502, https://openalex.org/W6790594130, https://openalex.org/W3123349121, https://openalex.org/W2912786033, https://openalex.org/W3193897711, https://openalex.org/W2978384597, https://openalex.org/W3130971202, https://openalex.org/W2899479744, https://openalex.org/W3190429661, https://openalex.org/W4401739531, https://openalex.org/W3204213277, https://openalex.org/W4394765357, https://openalex.org/W4391106266, https://openalex.org/W3127919036 |
| referenced_works_count | 92 |
| abstract_inverted_index.a | 4 |
| abstract_inverted_index.DN | 176 |
| abstract_inverted_index.as | 42, 76, 152, 181 |
| abstract_inverted_index.by | 12, 124 |
| abstract_inverted_index.in | 25, 33, 102, 160, 175 |
| abstract_inverted_index.is | 3 |
| abstract_inverted_index.of | 7, 21, 69, 95, 108, 173 |
| abstract_inverted_index.DN. | 109 |
| abstract_inverted_index.and | 18, 37, 51, 57, 64, 78, 86, 100, 106, 113, 121, 130, 139, 156, 177, 187, 196 |
| abstract_inverted_index.for | 44, 184, 193 |
| abstract_inverted_index.key | 59 |
| abstract_inverted_index.the | 67, 93, 103, 170, 191 |
| abstract_inverted_index.way | 192 |
| abstract_inverted_index.(DN) | 2 |
| abstract_inverted_index.DN's | 34 |
| abstract_inverted_index.This | 167 |
| abstract_inverted_index.cell | 116 |
| abstract_inverted_index.have | 28 |
| abstract_inverted_index.into | 164 |
| abstract_inverted_index.like | 98 |
| abstract_inverted_index.role | 32 |
| abstract_inverted_index.such | 75, 151 |
| abstract_inverted_index.with | 72 |
| abstract_inverted_index.(DM), | 10 |
| abstract_inverted_index.early | 104 |
| abstract_inverted_index.life. | 22 |
| abstract_inverted_index.miR-7 | 99 |
| abstract_inverted_index.roles | 172 |
| abstract_inverted_index.their | 30, 144, 179 |
| abstract_inverted_index.these | 148, 162 |
| abstract_inverted_index.tools | 183 |
| abstract_inverted_index.which | 53, 80 |
| abstract_inverted_index.Recent | 23 |
| abstract_inverted_index.axonal | 84, 132 |
| abstract_inverted_index.cargo, | 46 |
| abstract_inverted_index.expand | 143 |
| abstract_inverted_index.future | 194 |
| abstract_inverted_index.induce | 66 |
| abstract_inverted_index.paving | 190 |
| abstract_inverted_index.remain | 159 |
| abstract_inverted_index.review | 168 |
| abstract_inverted_index.Despite | 147 |
| abstract_inverted_index.Schwann | 111 |
| abstract_inverted_index.crucial | 31 |
| abstract_inverted_index.damage, | 15 |
| abstract_inverted_index.disrupt | 81 |
| abstract_inverted_index.effects | 123 |
| abstract_inverted_index.exosome | 26 |
| abstract_inverted_index.further | 142 |
| abstract_inverted_index.lipids, | 52 |
| abstract_inverted_index.mediate | 54 |
| abstract_inverted_index.miR-221 | 101 |
| abstract_inverted_index.miRNAs, | 74 |
| abstract_inverted_index.quality | 20 |
| abstract_inverted_index.release | 68 |
| abstract_inverted_index.repair. | 133 |
| abstract_inverted_index.sensory | 16 |
| abstract_inverted_index.stromal | 115 |
| abstract_inverted_index.studies | 91 |
| abstract_inverted_index.utility | 94 |
| abstract_inverted_index.Diabetic | 0 |
| abstract_inverted_index.Emerging | 134 |
| abstract_inverted_index.advances | 24 |
| abstract_inverted_index.clinical | 157, 165, 197 |
| abstract_inverted_index.diabetes | 8 |
| abstract_inverted_index.enriched | 71 |
| abstract_inverted_index.exosomal | 96 |
| abstract_inverted_index.exosomes | 70, 118, 138, 174 |
| abstract_inverted_index.findings | 163 |
| abstract_inverted_index.impaired | 19 |
| abstract_inverted_index.mellitus | 9 |
| abstract_inverted_index.miR-130a | 77 |
| abstract_inverted_index.neuronal | 14, 82 |
| abstract_inverted_index.regulate | 58 |
| abstract_inverted_index.research | 27, 195 |
| abstract_inverted_index.targeted | 188 |
| abstract_inverted_index.vehicles | 43 |
| abstract_inverted_index.(miRNAs), | 49 |
| abstract_inverted_index.advances, | 149 |
| abstract_inverted_index.detection | 105 |
| abstract_inverted_index.enhancing | 125 |
| abstract_inverted_index.function, | 83, 127 |
| abstract_inverted_index.highlight | 92 |
| abstract_inverted_index.including | 47, 136 |
| abstract_inverted_index.microRNAs | 48 |
| abstract_inverted_index.molecular | 45 |
| abstract_inverted_index.pathways. | 88 |
| abstract_inverted_index.potential | 180 |
| abstract_inverted_index.practice. | 166 |
| abstract_inverted_index.precision | 185 |
| abstract_inverted_index.promoting | 131 |
| abstract_inverted_index.proteins, | 50 |
| abstract_inverted_index.vesicles, | 141 |
| abstract_inverted_index.biological | 60 |
| abstract_inverted_index.biomarkers | 97 |
| abstract_inverted_index.challenges | 150 |
| abstract_inverted_index.diagnosis, | 36 |
| abstract_inverted_index.diagnostic | 90 |
| abstract_inverted_index.elucidated | 29 |
| abstract_inverted_index.engineered | 137 |
| abstract_inverted_index.highlights | 178 |
| abstract_inverted_index.innovative | 182 |
| abstract_inverted_index.modulating | 128 |
| abstract_inverted_index.monitoring | 107 |
| abstract_inverted_index.neuropathy | 1 |
| abstract_inverted_index.pathogenic | 73 |
| abstract_inverted_index.potential. | 146 |
| abstract_inverted_index.processes. | 61 |
| abstract_inverted_index.reparative | 122 |
| abstract_inverted_index.therapies, | 189 |
| abstract_inverted_index.treatment. | 38 |
| abstract_inverted_index.validation | 158 |
| abstract_inverted_index.Conversely, | 89 |
| abstract_inverted_index.approaches, | 135 |
| abstract_inverted_index.demonstrate | 119 |
| abstract_inverted_index.diagnostics | 186 |
| abstract_inverted_index.large-scale | 154 |
| abstract_inverted_index.mesenchymal | 114 |
| abstract_inverted_index.miR-20b-3p, | 79 |
| abstract_inverted_index.production, | 155 |
| abstract_inverted_index.progressive | 13 |
| abstract_inverted_index.therapeutic | 145 |
| abstract_inverted_index.translating | 161 |
| abstract_inverted_index.underscores | 169 |
| abstract_inverted_index.cell-derived | 112 |
| abstract_inverted_index.complication | 6 |
| abstract_inverted_index.debilitating | 5 |
| abstract_inverted_index.dysfunction, | 17 |
| abstract_inverted_index.inflammatory | 87 |
| abstract_inverted_index.multifaceted | 171 |
| abstract_inverted_index.(MSC)-derived | 117 |
| abstract_inverted_index.applications. | 198 |
| abstract_inverted_index.characterized | 11 |
| abstract_inverted_index.communication | 56 |
| abstract_inverted_index.extracellular | 40 |
| abstract_inverted_index.hyperglycemia | 63 |
| abstract_inverted_index.inflammation, | 129 |
| abstract_inverted_index.intercellular | 55 |
| abstract_inverted_index.mitochondrial | 126 |
| abstract_inverted_index.pathogenesis, | 35 |
| abstract_inverted_index.regeneration, | 85 |
| abstract_inverted_index.hyperlipidemia | 65 |
| abstract_inverted_index.miRNA-enriched | 140 |
| abstract_inverted_index.Pathologically, | 62 |
| abstract_inverted_index.neuroprotective | 120 |
| abstract_inverted_index.Therapeutically, | 110 |
| abstract_inverted_index.standardization, | 153 |
| abstract_inverted_index.vesicles-function | 41 |
| abstract_inverted_index.Exosomes-nanoscale | 39 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 98 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 7 |
| citation_normalized_percentile.value | 0.97605935 |
| citation_normalized_percentile.is_in_top_1_percent | True |
| citation_normalized_percentile.is_in_top_10_percent | True |