Exploring the role of pericardial miRNAs and exosomes in modulating cardiac fibrosis Article Swipe
Friederike I. Schoettler
,
Ali Fatehi Hassanabad
,
Anshul S. Jadli
,
Vaibhav B. Patel
,
Paul W.M. Fedak
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.carpath.2024.107671
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.carpath.2024.107671
The potential of the pericardial space as a therapeutic delivery tool for cardiac fibrosis and heart failure (HF) treatment has yet to be elucidated. Recently, miRNAs and exosomes have been discovered to be present in human pericardial fluid (PF). Novel studies have shown characteristic human PF miRNA compositions associated with cardiac diseases and higher miRNA expressions in PF compared to peripheral blood. Five key studies found differentially expressed miRNAs in HF, angina pectoris, aortic stenosis, ventricular tachycardia, and congenital heart diseases with either atrial fibrillation or sinus rhythm. As miRNA-based therapeutics for cardiac fibrosis and HF showed promising results in several in vivo studies for multiple miRNAs, we hypothesize a potential role of miRNA-based therapeutics delivered through the pericardial cavity. This is underlined by the favorable results of the first phase 1b clinical trial in this emerging field. Presenting the first human miRNA antisense drug trial, inhibition of miR-132 by intravenous administration of a novel antisense oligonucleotide, CDR132L, established efficacy in reducing miR-132 in plasma samples in a dose-dependent manner. We screened the literature, provided an overview of the miRNAs and exosomes present in PF, and drew a connection to those miRNAs previously elucidated in cardiac fibrosis and HF. Further, we speculate about clinical implications and potential delivery methods.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.carpath.2024.107671
- OA Status
- hybrid
- Cited By
- 7
- References
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- Related Works
- 10
- OpenAlex ID
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All OpenAlex metadata
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- OpenAlex ID
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https://openalex.org/W4399795964Canonical identifier for this work in OpenAlex
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https://doi.org/10.1016/j.carpath.2024.107671Digital Object Identifier
- Title
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Exploring the role of pericardial miRNAs and exosomes in modulating cardiac fibrosisWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
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2024Year of publication
- Publication date
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2024-06-19Full publication date if available
- Authors
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Friederike I. Schoettler, Ali Fatehi Hassanabad, Anshul S. Jadli, Vaibhav B. Patel, Paul W.M. FedakList of authors in order
- Landing page
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https://doi.org/10.1016/j.carpath.2024.107671Publisher landing page
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://doi.org/10.1016/j.carpath.2024.107671Direct OA link when available
- Concepts
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Medicine, Cardiac fibrosis, microRNA, Fibrosis, Atrial fibrillation, Heart failure, Microvesicles, Cardiology, Myocardial fibrosis, Exosome, Sinus rhythm, Internal medicine, Bioinformatics, Pharmacology, Biology, Biochemistry, GeneTop concepts (fields/topics) attached by OpenAlex
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7Total citation count in OpenAlex
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2025: 5, 2024: 2Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.emerging | 136 |
| abstract_inverted_index.exosomes | 27, 181 |
| abstract_inverted_index.fibrosis | 13, 93, 196 |
| abstract_inverted_index.methods. | 208 |
| abstract_inverted_index.multiple | 105 |
| abstract_inverted_index.overview | 176 |
| abstract_inverted_index.provided | 174 |
| abstract_inverted_index.reducing | 161 |
| abstract_inverted_index.screened | 171 |
| abstract_inverted_index.Recently, | 24 |
| abstract_inverted_index.antisense | 143, 155 |
| abstract_inverted_index.delivered | 115 |
| abstract_inverted_index.expressed | 67 |
| abstract_inverted_index.favorable | 125 |
| abstract_inverted_index.pectoris, | 72 |
| abstract_inverted_index.potential | 1, 110, 206 |
| abstract_inverted_index.promising | 97 |
| abstract_inverted_index.speculate | 201 |
| abstract_inverted_index.stenosis, | 74 |
| abstract_inverted_index.treatment | 18 |
| abstract_inverted_index.Presenting | 138 |
| abstract_inverted_index.associated | 48 |
| abstract_inverted_index.congenital | 78 |
| abstract_inverted_index.connection | 188 |
| abstract_inverted_index.discovered | 30 |
| abstract_inverted_index.elucidated | 193 |
| abstract_inverted_index.inhibition | 146 |
| abstract_inverted_index.peripheral | 60 |
| abstract_inverted_index.previously | 192 |
| abstract_inverted_index.underlined | 122 |
| abstract_inverted_index.elucidated. | 23 |
| abstract_inverted_index.established | 158 |
| abstract_inverted_index.expressions | 55 |
| abstract_inverted_index.hypothesize | 108 |
| abstract_inverted_index.intravenous | 150 |
| abstract_inverted_index.literature, | 173 |
| abstract_inverted_index.miRNA-based | 89, 113 |
| abstract_inverted_index.pericardial | 4, 36, 118 |
| abstract_inverted_index.therapeutic | 8 |
| abstract_inverted_index.ventricular | 75 |
| abstract_inverted_index.compositions | 47 |
| abstract_inverted_index.fibrillation | 84 |
| abstract_inverted_index.implications | 204 |
| abstract_inverted_index.tachycardia, | 76 |
| abstract_inverted_index.therapeutics | 90, 114 |
| abstract_inverted_index.administration | 151 |
| abstract_inverted_index.characteristic | 43 |
| abstract_inverted_index.differentially | 66 |
| abstract_inverted_index.dose-dependent | 168 |
| abstract_inverted_index.oligonucleotide, | 156 |
| cited_by_percentile_year.max | 98 |
| cited_by_percentile_year.min | 94 |
| corresponding_author_ids | https://openalex.org/A5049131213 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 5 |
| corresponding_institution_ids | https://openalex.org/I168635309, https://openalex.org/I56478863 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/2 |
| sustainable_development_goals[0].score | 0.44999998807907104 |
| sustainable_development_goals[0].display_name | Zero hunger |
| citation_normalized_percentile.value | 0.94033204 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |