Exploring the Role of PPARs and Endothelial Dysfunction in MASLD Article Swipe
Ana Paula Madariaga Traconis
,
Varenka Julieta Barbero Becerra
,
Misael Uribe
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.20944/preprints202411.1116.v1
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.20944/preprints202411.1116.v1
Peroxisome proliferator-activated receptors (PPARs) are a family of transcription factors that belong to the superfamily of nuclear hormone receptors expressed in various tissues, with each isoform having a distinct localization and function. In general, PPARs have an important role in fatty acid catabolism, the reduction of reactive oxygen species, and endothelial function. Specifically, PPAR functions through mechanisms such as transrepression of nuclear factor kappa B (NF-B), thereby modulating inflammatory responses and maintaining hepatic homeostasis. Together, PPAR and PPAR influence endothelial function and vascular health, which are critically affected in the context of MASLD. The complex interplay between PPARs, endothelial dysfunction, and MASLD highlights the potential of PPARs as a pharmacological target for therapeutic interventions. Recent advances in understanding the role of PPAR in modulating inflammation and endothelial function have led to the exploration of PPAR agonists in clinical trials and experimental studies. Agents such as lanifibranor, elafibranor, daidzein, and Iicarin have shown promise in improving metabolic, hepatic, and cardiovascular health in patients with MASLD. This review aimed to provide a comprehensive overview of the role of PPARs in endothelial dysfunction and MASLD, exploring their mechanisms in disease progression and potential pharmacological targeting.
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All OpenAlex metadata
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https://doi.org/10.20944/preprints202411.1116.v1Digital Object Identifier
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Exploring the Role of PPARs and Endothelial Dysfunction in MASLDWork title
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preprintOpenAlex work type
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enPrimary language
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2024Year of publication
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2024-11-15Full publication date if available
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Ana Paula Madariaga Traconis, Varenka Julieta Barbero Becerra, Misael UribeList of authors in order
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https://doi.org/10.20944/preprints202411.1116.v1Publisher landing page
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
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https://doi.org/10.20944/preprints202411.1116.v1Direct OA link when available
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Endothelial dysfunction, Internal medicine, MedicineTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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