Exploring the roles of airway dipeptidyl peptidase 1 in obstructive airway disease Article Swipe
Naoya Tanabe
,
Hisako Matsumoto
,
Mariko Kogo
,
Chie Morimoto
,
Natsuko Nomura
,
Yusuke Hayashi
,
Ryo Sakamoto
,
Tsuyoshi Oguma
,
Tadao Nagasaki
,
Hironobu Sunadome
,
Atsuyasu Sato
,
Susumu Satō
,
Kai Ohashi
,
Takamitsu Tsukahara
,
Toyohiro Hirai
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1183/23120541.00841-2024
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1183/23120541.00841-2024
Background Dipeptidyl peptidase 1 (DPP1) exacerbates airway neutrophilic inflammation in bronchiectasis, which is characterised by airway dysfunction and dilation and chronic bacterial infection. However, little is known about the pathogenetic roles of DPP1 in obstructive airway diseases, including COPD, asthma and asthma–COPD overlap (ACO). Here, we tested the hypothesis that airway DPP1 could enhance neutrophilic inflammation and affect mucus plugging, airway dilation and the airway microbiome in patients with these diseases. Methods Sputum DPP1, cell differential count and microbiome were cross-sectionally evaluated in patients with COPD, asthma with airflow limitation and ACO. Sputum high mobility group box 1 (HMGB1) was measured to estimate airway epithelial damage. Chest computed tomography was also performed to visually assess mucus plugs and airway dilation with the Reiff score and quantify the total airway count and wall area percentage. Results 68 patients were classified into high-DPP1/high-neutrophil (n=17), low-DPP1/high-neutrophil (n=37) and low-neutrophil (n=14) groups based on sputum DPP1 levels and neutrophil percentages. The rate of mucus plugging and the relative abundance of the phylum Firmicutes were significantly lower and the level of sputum HMGB1 was significantly greater in the high-DPP1/high-neutrophil group than in the low-DPP1/high-neutrophil group. Moreover, airway dilation without mucus plugging was observed only in the high-DPP1/high-neutrophil group (prevalence 29%). Conclusions High sputum DPP1 levels may reduce colonisation by the phylum Firmicutes and mucus plugging, but increase airway epithelial damage, which could induce airway dilation without mucus plugging in patients with obstructive airway disease with neutrophilic inflammation.
Related Topics
Concepts
Medicine
Airway
Dipeptidyl peptidase-4
Intensive care medicine
Surgery
Endocrinology
Diabetes mellitus
Type 2 diabetes
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1183/23120541.00841-2024
- OA Status
- gold
- Cited By
- 3
- References
- 40
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4404374173
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4404374173Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1183/23120541.00841-2024Digital Object Identifier
- Title
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Exploring the roles of airway dipeptidyl peptidase 1 in obstructive airway diseaseWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-11-14Full publication date if available
- Authors
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Naoya Tanabe, Hisako Matsumoto, Mariko Kogo, Chie Morimoto, Natsuko Nomura, Yusuke Hayashi, Ryo Sakamoto, Tsuyoshi Oguma, Tadao Nagasaki, Hironobu Sunadome, Atsuyasu Sato, Susumu Satō, Kai Ohashi, Takamitsu Tsukahara, Toyohiro HiraiList of authors in order
- Landing page
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https://doi.org/10.1183/23120541.00841-2024Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.1183/23120541.00841-2024Direct OA link when available
- Concepts
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Medicine, Airway, Dipeptidyl peptidase-4, Intensive care medicine, Surgery, Endocrinology, Diabetes mellitus, Type 2 diabetesTop concepts (fields/topics) attached by OpenAlex
- Cited by
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3Total citation count in OpenAlex
- Citations by year (recent)
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2025: 3Per-year citation counts (last 5 years)
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40Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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