Exploring varicella zoster virus proteome for construction and validation of a multi-epitope based subunit vaccine using multifaceted immunoinformatics approaches Article Swipe
Yassir A. Almofti
,
Abdullahi Ali Ibrahim
,
Nuha Mahmoud
,
Abdelmajeed M. Elshafei
,
Nazlina Ibrahim
,
Ibrahim Albokhadaim
,
Saad Shousha
,
Ahmed Omer Alameen
,
Nawal Mohamed Elkhair
,
Mahmoud G. El Sebaei
,
Mahmoud Kandeel
,
Samir Alhojaily
,
Sheryar Afzal
,
Mohammed Alhammadi
,
M Ghada
,
Ali Attiq
,
Yuan Seng Wu
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1371/journal.pone.0324453
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1371/journal.pone.0324453
Varicella zoster (VZ) is a viral disease caused by varicella zoster virus (VZV) that is related to alphaherpesvirus subfamily. VZV causes a neurotropic disease in humans. The aim of this work was to stimulate the human immune system by developing a multi-epitope vaccine based on five VZV surface proteins. Multiple immunoinformatics techniques were applied to assess B-cell and T-cell epitopes. The population coverage of each T-cell epitope was analyzed and the results showed high population coverage scores. The vaccine consists of 615 amino acids and it was antigenic and non-allergenic. The vaccine’s hydrophilicity, stability, presence of aliphatic side chains, and thermal stability were all determined through an analysis of its physical and chemical characteristics. Also the vaccine demonstrated the least homology to human proteome (11%). Using the PSIPRED server and the Ramachandran plot, the vaccine’s secondary and tertiary structures were predicted, enhanced, and validated. The structural errors were assessed using the ProSA web tool. Furthermore, the vaccine’s solubility was higher than that of the E. coli proteins. Following immune simulation, there were significant amounts of T-cells, INF-γ, IL-2, and antibodies. Significant docking scores were obtained for each predicted epitopes and for the vaccine when docked to TLR4 chains. The TLR4-vaccine complex was highly stable according to molecular dynamic modeling. In silico cloning was performed to assess the vaccine’s expression in the pET28a(+) vector, and the cloning results were efficient for translation. To ascertain the vaccine’s effectiveness, in vivo and in vitro investigations, including clinical trials are required.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1371/journal.pone.0324453
- OA Status
- gold
- Cited By
- 1
- References
- 105
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4411601561
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4411601561Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1371/journal.pone.0324453Digital Object Identifier
- Title
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Exploring varicella zoster virus proteome for construction and validation of a multi-epitope based subunit vaccine using multifaceted immunoinformatics approachesWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-06-24Full publication date if available
- Authors
-
Yassir A. Almofti, Abdullahi Ali Ibrahim, Nuha Mahmoud, Abdelmajeed M. Elshafei, Nazlina Ibrahim, Ibrahim Albokhadaim, Saad Shousha, Ahmed Omer Alameen, Nawal Mohamed Elkhair, Mahmoud G. El Sebaei, Mahmoud Kandeel, Samir Alhojaily, Sheryar Afzal, Mohammed Alhammadi, M Ghada, Ali Attiq, Yuan Seng WuList of authors in order
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https://doi.org/10.1371/journal.pone.0324453Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.1371/journal.pone.0324453Direct OA link when available
- Concepts
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Epitope, Virology, Varicella zoster virus, Biology, Population, Virus, Immune system, Antibody, Medicine, Immunology, Environmental healthTop concepts (fields/topics) attached by OpenAlex
- Cited by
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1Total citation count in OpenAlex
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2025: 1Per-year citation counts (last 5 years)
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105Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| corresponding_author_ids | https://openalex.org/A5056675137, https://openalex.org/A5004951829, https://openalex.org/A5008300214, https://openalex.org/A5002403636, https://openalex.org/A5024818296, https://openalex.org/A5118613575, https://openalex.org/A5062667572, https://openalex.org/A5114494129, https://openalex.org/A5052933490, https://openalex.org/A5051501892, https://openalex.org/A5111364429, https://openalex.org/A5028647200, https://openalex.org/A5068302496, https://openalex.org/A5043847017, https://openalex.org/A5074536318, https://openalex.org/A5029605964, https://openalex.org/A5072261828 |
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