Exposure to heavy metalsin uteroand autism spectrum disorder at age 3: A meta-analysis of two longitudinal cohorts of siblings of children with autism Article Swipe
John Dou
,
Rebecca J. Schmidt
,
Heather E. Volk
,
Manon M. Nitta
,
Jason I. Feinberg
,
Craig J. Newschaffer
,
Lisa Croen
,
Irva Hertz‐Picciotto
,
M. Daniele Fallin
,
Kelly M. Bakulski
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1101/2023.11.21.23298827
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1101/2023.11.21.23298827
Background Autism spectrum disorder (ASD) is a prevalent and heterogeneous neurodevelopmental disorder. Risk is attributed to genetic and prenatal environmental factors, though the environmental agents are incompletely characterized. Methods In Early Autism Risk Longitudinal Investigation (EARLI) and Markers of Autism Risk in Babies Learning Early Signs (MARBLES), two pregnancy cohorts of siblings of children with ASD, maternal urinary metals concentrations at two time points during pregnancy were measured using inductively coupled plasma mass spectrometry. At age three, clinicians assessed ASD with DSM-5 criteria. Using multivariable log binomial regression, we examined each metal for association with ASD status, adjusting for gestational age at urine sampling, child sex, maternal age, and maternal education, and meta-analyzed across the two cohorts. Results In EARLI (n=170) 17.6% of children were diagnosed with ASD, and an additional 43.5% were classified as having other non-neurotypical development (Non-TD). In MARBLES (n=156), 22.7% were diagnosed with ASD, while an additional 11.5% had Non-TD. In earlier pregnancy metals measures, having cadmium concentration over the level of detection was associated with 1.78 (1.19, 2.67) times higher risk of ASD, and 1.43 (1.06, 1.92) times higher risk of Non-TD. A doubling of early pregnancy cesium concentration was marginally associated with 1.81 (0.95, 3.42) times higher risk of ASD, and 1.58 (0.95, 2.63) times higher risk of Non-TD. Conclusion Exposure in utero to elevated levels of cadmium and cesium, as measured in maternal urine collected during pregnancy, was associated with increased risk of developing ASD.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2023.11.21.23298827
- https://www.medrxiv.org/content/medrxiv/early/2023/12/05/2023.11.21.23298827.full.pdf
- OA Status
- green
- Cited By
- 1
- References
- 40
- Related Works
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- OpenAlex ID
- https://openalex.org/W4388893734
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4388893734Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2023.11.21.23298827Digital Object Identifier
- Title
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Exposure to heavy metalsin uteroand autism spectrum disorder at age 3: A meta-analysis of two longitudinal cohorts of siblings of children with autismWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
-
2023-11-22Full publication date if available
- Authors
-
John Dou, Rebecca J. Schmidt, Heather E. Volk, Manon M. Nitta, Jason I. Feinberg, Craig J. Newschaffer, Lisa Croen, Irva Hertz‐Picciotto, M. Daniele Fallin, Kelly M. BakulskiList of authors in order
- Landing page
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https://doi.org/10.1101/2023.11.21.23298827Publisher landing page
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https://www.medrxiv.org/content/medrxiv/early/2023/12/05/2023.11.21.23298827.full.pdfDirect link to full text PDF
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YesWhether a free full text is available
- OA status
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greenOpen access status per OpenAlex
- OA URL
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https://www.medrxiv.org/content/medrxiv/early/2023/12/05/2023.11.21.23298827.full.pdfDirect OA link when available
- Concepts
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Autism spectrum disorder, Pregnancy, Autism, Neurotypical, Medicine, Gestational age, Urine, Generation R, Obstetrics, Pediatrics, Cohort study, Psychiatry, Internal medicine, Biology, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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1Total citation count in OpenAlex
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2023: 1Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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