Expression and clinical significance of interleukin-6 pathway in cholangiocarcinoma Article Swipe
Dongqing Gu
,
Xin Zhao
,
Jing Song
,
Jianmei Xiao
,
Leida Zhang
,
Guohong Deng
,
Dajiang Li
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3389/fimmu.2024.1374967
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3389/fimmu.2024.1374967
Background Cholangiocarcinoma (CCA) is a typical inflammation-induced malignancy, and elevated serum interleukin-6 (IL-6) levels have been reported to be linked to the onset and progression of CCA. We aim to investigate the potential prognostic value of the IL-6 pathway for CCA. Methods We detected the expressions of IL-6, IL-6R, glycoprotein (gp130), C-reactive protein (CRP), Janus kinase 2 (JAK2), and signal transducer and activator of transcription 3 (STAT3) in CCA tissue microarray using multiplex immunofluorescence. Furthermore, the clinical associations and prognostic values were assessed. Finally, single-cell transcriptome analysis was performed to evaluate the expression level of IL-6 pathway genes in CCA. Results The results revealed that the expression of IL-6 was lower, while the expression of STAT3 was higher in tumor tissues compared to normal tissues. Especially in tumor microenvironment, the expression of IL-6 pathway genes was generally downregulated. Importantly, gp130 was strongly correlated with JAK2 in tumor tissues, while it was moderately correlated with JAK2 in normal tissue. Although none of the gene expressions were directly associated with overall survival and disease-free survival, our study found that IL-6, IL-6R, CRP, gp130, and JAK2 were inversely correlated with vascular invasion, which is a risk factor for poor prognosis in patients with CCA. Conclusion The findings from this study suggest that the IL-6 signaling pathway may have a potential prognostic value for CCA. Further investigation is needed to understand the underlying molecular mechanisms of the IL-6 pathway in CCA.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fimmu.2024.1374967
- https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1374967/pdf
- OA Status
- gold
- Cited By
- 1
- References
- 32
- Related Works
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- OpenAlex ID
- https://openalex.org/W4399246948
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4399246948Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fimmu.2024.1374967Digital Object Identifier
- Title
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Expression and clinical significance of interleukin-6 pathway in cholangiocarcinomaWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-05-31Full publication date if available
- Authors
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Dongqing Gu, Xin Zhao, Jing Song, Jianmei Xiao, Leida Zhang, Guohong Deng, Dajiang LiList of authors in order
- Landing page
-
https://doi.org/10.3389/fimmu.2024.1374967Publisher landing page
- PDF URL
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https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1374967/pdfDirect link to full text PDF
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YesWhether a free full text is available
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-
goldOpen access status per OpenAlex
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https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1374967/pdfDirect OA link when available
- Concepts
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Cancer research, Medicine, Clinical significance, Interleukin, Immunology, Biology, Internal medicine, CytokineTop concepts (fields/topics) attached by OpenAlex
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1Total citation count in OpenAlex
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2025: 1Per-year citation counts (last 5 years)
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32Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.inversely | 184 |
| abstract_inverted_index.molecular | 229 |
| abstract_inverted_index.multiplex | 72 |
| abstract_inverted_index.performed | 88 |
| abstract_inverted_index.potential | 32, 216 |
| abstract_inverted_index.prognosis | 196 |
| abstract_inverted_index.signaling | 211 |
| abstract_inverted_index.survival, | 172 |
| abstract_inverted_index.Background | 0 |
| abstract_inverted_index.C-reactive | 51 |
| abstract_inverted_index.Conclusion | 201 |
| abstract_inverted_index.Especially | 125 |
| abstract_inverted_index.associated | 166 |
| abstract_inverted_index.correlated | 142, 152, 185 |
| abstract_inverted_index.expression | 92, 106, 113, 130 |
| abstract_inverted_index.mechanisms | 230 |
| abstract_inverted_index.microarray | 70 |
| abstract_inverted_index.moderately | 151 |
| abstract_inverted_index.prognostic | 33, 79, 217 |
| abstract_inverted_index.transducer | 60 |
| abstract_inverted_index.underlying | 228 |
| abstract_inverted_index.understand | 226 |
| abstract_inverted_index.expressions | 45, 163 |
| abstract_inverted_index.investigate | 30 |
| abstract_inverted_index.malignancy, | 7 |
| abstract_inverted_index.progression | 24 |
| abstract_inverted_index.single-cell | 84 |
| abstract_inverted_index.Furthermore, | 74 |
| abstract_inverted_index.Importantly, | 138 |
| abstract_inverted_index.associations | 77 |
| abstract_inverted_index.disease-free | 171 |
| abstract_inverted_index.glycoprotein | 49 |
| abstract_inverted_index.interleukin-6 | 11 |
| abstract_inverted_index.investigation | 222 |
| abstract_inverted_index.transcription | 64 |
| abstract_inverted_index.transcriptome | 85 |
| abstract_inverted_index.downregulated. | 137 |
| abstract_inverted_index.microenvironment, | 128 |
| abstract_inverted_index.Cholangiocarcinoma | 1 |
| abstract_inverted_index.immunofluorescence. | 73 |
| abstract_inverted_index.inflammation-induced | 6 |
| cited_by_percentile_year.max | 95 |
| cited_by_percentile_year.min | 91 |
| corresponding_author_ids | https://openalex.org/A5027337916, https://openalex.org/A5101510765 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 7 |
| corresponding_institution_ids | https://openalex.org/I151075929, https://openalex.org/I4210131174 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.5099999904632568 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.7077679 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |