Expression and Regulation of a Novel Decidual Cells-Derived Estrogen Target during Decidualization Article Swipe
Lin Lü
,
Yingni Chen
,
Zhen‐Shan Yang
,
Shijin Liang
,
Songqi Zhu
,
Xiao‐Huan Liang
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/ijms24010302
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/ijms24010302
During decidualization in rodents, uterine stromal cells undergo extensive reprogramming to differentiate into distinct cell types, forming primary decidual zones (PDZs), secondary decidual zones (SDZs), and layers of undifferentiated stromal cells. The formation of secondary decidual zones is accompanied by extensive angiogenesis. During early pregnancy, besides ovarian estrogen, de novo synthesis of estrogen in the uterus is essential for the progress of decidualization. However, the molecular mechanisms are not fully understood. Studies have shown that Cystatin B (Cstb) is highly expressed in the decidual tissue of the uterus, but the regulation and mechanism of Cstb in the process of decidualization have not been reported. Our results showed that Cstb was highly expressed in mouse decidua and artificially induced deciduoma via in situ hybridization and immunofluorescence. Estrogen stimulates the expression of Cstb through the Estrogen receptor (ER)α. Moreover, in situ synthesis of estrogen in the uterus during decidualization regulates the expression of Cstb. Silencing the expression of Cstb affects the migration ability of stromal cells. Knockdown Cstb by siRNA significantly inhibits the expression of Dtprp, a marker for mouse decidualization. Our study identifies a novel estrogen target, Cstb, during decidualization and reveals that Cstb may play a pivotal role in angiogenesis during mouse decidualization via the Angptl7.
Related Topics
Concepts
Decidualization
Decidua
Stromal cell
Decidual cells
Biology
Estrogen
Cell biology
Internal medicine
Endocrinology
Cancer research
Fetus
Pregnancy
Genetics
Placenta
Medicine
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/ijms24010302
- https://www.mdpi.com/1422-0067/24/1/302/pdf?version=1671876028
- OA Status
- gold
- Cited By
- 13
- References
- 44
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4313259782
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4313259782Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/ijms24010302Digital Object Identifier
- Title
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Expression and Regulation of a Novel Decidual Cells-Derived Estrogen Target during DecidualizationWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-12-24Full publication date if available
- Authors
-
Lin Lü, Yingni Chen, Zhen‐Shan Yang, Shijin Liang, Songqi Zhu, Xiao‐Huan LiangList of authors in order
- Landing page
-
https://doi.org/10.3390/ijms24010302Publisher landing page
- PDF URL
-
https://www.mdpi.com/1422-0067/24/1/302/pdf?version=1671876028Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
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https://www.mdpi.com/1422-0067/24/1/302/pdf?version=1671876028Direct OA link when available
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Decidualization, Decidua, Stromal cell, Decidual cells, Biology, Estrogen, Cell biology, Internal medicine, Endocrinology, Cancer research, Fetus, Pregnancy, Genetics, Placenta, MedicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
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13Total citation count in OpenAlex
- Citations by year (recent)
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2025: 2, 2024: 8, 2023: 3Per-year citation counts (last 5 years)
- References (count)
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44Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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