Expression of CD8+ and Foxp3+ T Lymphocyte as Predictor for Response to Neoadjuvant Chemotherapy in Stage III Breast Cancer Article Swipe
I Nyoman Wawan Tirtha Yasa
,
I Wayan Sudarsa
,
I Wayan Niryana
,
Ni Putu Sriwidyani
,
I Made Jawi
,
I Wayan Putu Sutirta Yasa
,
Ida Bagus Tjakra Wibawa Manuaba
,
Ida Bagus Made Suryawisesa
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.18585/inabj.v17i3.3680
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.18585/inabj.v17i3.3680
BACKGROUND: Neoadjuvant chemotherapy (NAC) in breast cancer is usually utilized to eradicate micro-metastasis, induce apoptosis in tumor cells, and reduce the primary tumor size, enabling surgical intervention. Recent studies have shown that tumor-infiltrating lymphocytes (TILs), especially cytotoxic CD8+ T cells and immunosuppressive Foxp3+ regulatory T cells, influence tumor response to treatment. However, their role as predictive markers for NAC response remains unclear. Therefore, this study was performed to investigate whether high expression of CD8+ and low expression of Foxp3+ T lymphocytes are associated with better response to NAC in stage III breast cancer patients.METHODS: Total of 60 biopsy samples from stage III breast cancer patients were included, comprising 30 subjects in the response group (+) and 30 subjects in the non-response group (−). The expression levels of CD8+ and Foxp3+ T lymphocytes in tumor tissue were assessed semi-quantitatively by immunohistochemistry (IHC), using a scoring system based on the proportion and intensity of positively stained cells (Black’s grading criteria).RESULTS: Stage III breast cancer with high expression of CD8+ T lymphocytes was significantly associated with a better response to NAC (p=0.004; OR=6.882). Meanwhile, low expression of Foxp3+ T lymphocytes was not significantly associated with chemotherapy response (p=0.067; OR=3.250). A higher tumor grade was also associated with an improved response to treatment. The probability of achieving a positive response to NAC in subjects presenting with high CD8+ expression, low Foxp3+ expression, and high tumor grade was estimated at 96.98%.CONCLUSION: The combination of high expression of CD8+ T lymphocyte, low expression of Foxp3+ T lymphocyte and high tumor grade might be useful to predict good response to NAC in stage III breast cancer.KEYWORDS: CD8+ T lymphocyte, Foxp3+ T lymphocyte, neoadjuvant chemotherapy, breast cancer
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.18585/inabj.v17i3.3680
- OA Status
- gold
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4411331799
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4411331799Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.18585/inabj.v17i3.3680Digital Object Identifier
- Title
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Expression of CD8+ and Foxp3+ T Lymphocyte as Predictor for Response to Neoadjuvant Chemotherapy in Stage III Breast CancerWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-06-16Full publication date if available
- Authors
-
I Nyoman Wawan Tirtha Yasa, I Wayan Sudarsa, I Wayan Niryana, Ni Putu Sriwidyani, I Made Jawi, I Wayan Putu Sutirta Yasa, Ida Bagus Tjakra Wibawa Manuaba, Ida Bagus Made SuryawisesaList of authors in order
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https://doi.org/10.18585/inabj.v17i3.3680Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.18585/inabj.v17i3.3680Direct OA link when available
- Concepts
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Breast cancer, Stage (stratigraphy), Medicine, Oncology, Chemotherapy, CD8, FOXP3, Lymphocyte, Risk factor, T lymphocyte, Immunology, Internal medicine, Cancer, Immune system, Biology, PaleontologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- Related works (count)
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10Other works algorithmically related by OpenAlex
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