Expression of Cyclooxygenase-2 in naturally occurring bovine cutaneous fibropapillomas Article Swipe

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Florentina Daraban Bocaneti , Gennaro Altamura , Annunziata Corteggio , Carmen Solcan , Elena Velescu , Giuseppe Borzacchiello ·

YOU? · · 2015 · Open Access · · DOI: https://doi.org/10.1515/pjvs-2015-0084

Bovine cutaneous fibropapillomas are benign skin tumours characterized by epithelial and dermal proliferation and induced by Bovine papillomaviruses (BPVs). Cyclooxygenase (COX) 1 and 2 are enzymes involved in pathological conditions, such as inflammation and epithelial carcinogenesis. Here we investigated biochemically and immunohistochemically COX-2 expression in bovine cutaneous fibropapillomas. Eight of twelve fibropapillomas (67%) showed COX-2 positive immunosignal mostly in the cytoplasm of the basal cell layer, while the normal skin did not stain. Biochemical analysis confirmed the expression of COX-2 in tumour samples. This study shows COX-2 expression in cutaneous fibropapillomas, suggesting a contribution in epithelial tumour development.

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Cyclooxygenase Immunohistochemistry Carcinogenesis Pathology Biology Inflammation Stain Staining Epithelium Pathological Cytoplasm Enzyme Molecular biology Immunology Medicine Cell biology Cancer Biochemistry Genetics

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Type: article
Language: en
Landing Page: https://doi.org/10.1515/pjvs-2015-0084
PDF: http://journals.pan.pl/Content/99422/PDF/24.pdf
OA Status: bronze
Cited By: 3
References: 14
Related Works: 10
OpenAlex ID: https://openalex.org/W2282212566

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DOI: https://doi.org/10.1515/pjvs-2015-0084

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Title: Expression of Cyclooxygenase-2 in naturally occurring bovine cutaneous fibropapillomas

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Type: article

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Language: en

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Publication year: 2015

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Publication date: 2015-09-01

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Authors: Florentina Daraban Bocaneti, Gennaro Altamura, Annunziata Corteggio, Carmen Solcan, Elena Velescu, Giuseppe Borzacchiello

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Landing page: https://doi.org/10.1515/pjvs-2015-0084

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PDF URL: https://journals.pan.pl/Content/99422/PDF/24.pdf

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Concepts: Cyclooxygenase, Immunohistochemistry, Carcinogenesis, Pathology, Biology, Inflammation, Stain, Staining, Epithelium, Pathological, Cytoplasm, Enzyme, Molecular biology, Immunology, Medicine, Cell biology, Cancer, Biochemistry, Genetics

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Cited by: 3

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Citations by year (recent): 2024: 1, 2023: 1, 2022: 1

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