Expression of L1 Cell Adhesion Molecule, a Nephronal Principal Cell Marker, in Nephrogenic Adenoma Article Swipe
Rahul Mannan
,
Xiao Ming Wang
,
Somnath Mahapatra
,
Susanna Wang
,
Anya Chinnaiyan
,
Stephanie L. Skala
,
Yuping Zhang
,
Lisa McMurry
,
Sylvia Zelenka-Wang
,
Xuhong Cao
,
Ankur R. Sangoi
,
Vipulkumar Dadhania
,
Maria M. Picken
,
Santosh Menon
,
Hikmat Al‐Ahmadie
,
Arul M. Chinnaiyan
,
Saravana M. Dhanasekaran
,
Rohit Mehra
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.modpat.2024.100540
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.modpat.2024.100540
Nephrogenic adenoma (NA) is a benign, reactive lesion seen predominantly in the urinary bladder and often associated with antecedent inflammation, instrumentation, or an operative history. Its histopathologic diversity can create diagnostic dilemmas and pathologists use morphologic evaluation along with available immunohistochemical (IHC) markers to navigate these challenges. IHC assays currently do not designate or specify NA's potential putative cell of origin. Leveraging single-cell RNA-sequencing technology, we nominated a principal (P) cell-collecting duct marker, L1 cell adhesion molecule (L1CAM), as a potential biomarker for NA. IHC characterization revealed L1CAM to be positive in all 35 (100%) patient samples of NA; negative expression was seen in the benign urothelium, benign prostatic glands, urothelial carcinoma (UCA) in situ, prostatic adenocarcinoma, majority of high-grade UCA, and metastatic UCA. In the study, we also used single-cell RNA sequencing to nominate a novel compendium of biomarkers specific for the proximal tubule, loop of Henle, and distal tubule (DT) (including P and intercalated cells), which can be used to perform nephronal mapping using RNA in situ hybridization and IHC technology. Employing this technique on NA we found enrichment of both the P-cell marker L1CAM and, the proximal tubule type-A and -B cell markers, PDZKI1P1 and PIGR, respectively. The cell-type markers for the intercalated cell of DTs (LINC01187 and FOXI1), and the loop of Henle (UMOD and IRX5), were found to be uniformly absent in NA. Overall, our findings show that based on cell type-specific implications of L1CAM expression, the shared expression pattern of L1CAM between DT P cells and NA. L1CAM expression will be of potential value in assisting surgical pathologists toward a diagnosis of NA in challenging patient samples.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.modpat.2024.100540
- OA Status
- hybrid
- Cited By
- 4
- References
- 42
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4399786970
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4399786970Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1016/j.modpat.2024.100540Digital Object Identifier
- Title
-
Expression of L1 Cell Adhesion Molecule, a Nephronal Principal Cell Marker, in Nephrogenic AdenomaWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-06-18Full publication date if available
- Authors
-
Rahul Mannan, Xiao Ming Wang, Somnath Mahapatra, Susanna Wang, Anya Chinnaiyan, Stephanie L. Skala, Yuping Zhang, Lisa McMurry, Sylvia Zelenka-Wang, Xuhong Cao, Ankur R. Sangoi, Vipulkumar Dadhania, Maria M. Picken, Santosh Menon, Hikmat Al‐Ahmadie, Arul M. Chinnaiyan, Saravana M. Dhanasekaran, Rohit MehraList of authors in order
- Landing page
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https://doi.org/10.1016/j.modpat.2024.100540Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1016/j.modpat.2024.100540Direct OA link when available
- Concepts
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Pathology, Cell adhesion molecule, L1, Cell, Cell adhesion, Medicine, Chemistry, Internal medicine, Immunology, Biochemistry, Human papillomavirusTop concepts (fields/topics) attached by OpenAlex
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4Total citation count in OpenAlex
- Citations by year (recent)
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2025: 4Per-year citation counts (last 5 years)
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42Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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