Expression of Mucins in Different Entities of Salivary Gland Cancer: Highest Expression of Mucin-1 in Salivary Duct Carcinoma Article Swipe
Philipp Wolber
,
Marcel Mayer
,
Lisa Nachtsheim
,
Johanna Prinz
,
Jens Peter Klußmann
,
Alexander Quaas
,
Christoph Arolt
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1007/s12105-022-01448-3
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1007/s12105-022-01448-3
Therapeutic options for advanced salivary gland cancer (SGC) are rare. Therefore, it was the aim of this study to investigate the extent and intensity of Mucin-1 (MUC1), Mucin-16 (MUC16), and Mucin-5AC (MUC5AC) as potential molecular targets using immunohistochemistry. The medical records of all patients who underwent primary surgery for salivary gland cancer with curative intent in a tertiary referral center between 1990 and 2018 were reviewed. Immunohistochemical staining for MUC1, MUC16, and MUC5AC was performed for all patients with sufficient formalin-fixed paraffin-embedded material, and a semi-quantitative combined score derived from the H-score for the cytoplasmatic, the membranous and the apical membrane was built for the most common entities of SGC. 107 patients with malignancies of the parotid (89.7%) and the submandibular gland (10.3%) were included. The most common entities were mucoepidermoid carcinoma (MuEp; n = 23), adenoid cystic carcinoma (AdCy; n = 22), and salivary duct carcinoma (SaDu; n = 21). The highest mean MUC1 combined score was found in SaDu with 223.6 (±91.7). The highest mean MUC16 combined score was found in MuEp with 177.0 (±110.0). The mean MUC5AC score was low across all entities. A higher MUC1 combined score was significantly associated with male gender (p = 0.03), lymph node metastasis (p < 0.01), lymphovascular invasion (p = 0.045), and extracapsular extension (p = 0.03). SaDu patients with MUC16 expression showed a significantly worse 5-year progression-free survival than those without MUC16 expression (p = 0.02). This is the first study to give a comprehensive overview of the expression of MUC1, MUC16, and MUC5AC in SGC. Since advanced SGCs lack therapeutic options in many cases, these results warrant in vitro research on therapeutic targets against MUC1 in SaDu cell lines and xenograft models.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1007/s12105-022-01448-3
- https://link.springer.com/content/pdf/10.1007/s12105-022-01448-3.pdf
- OA Status
- hybrid
- Cited By
- 4
- References
- 42
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4226177060
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4226177060Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1007/s12105-022-01448-3Digital Object Identifier
- Title
-
Expression of Mucins in Different Entities of Salivary Gland Cancer: Highest Expression of Mucin-1 in Salivary Duct CarcinomaWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-04-07Full publication date if available
- Authors
-
Philipp Wolber, Marcel Mayer, Lisa Nachtsheim, Johanna Prinz, Jens Peter Klußmann, Alexander Quaas, Christoph AroltList of authors in order
- Landing page
-
https://doi.org/10.1007/s12105-022-01448-3Publisher landing page
- PDF URL
-
https://link.springer.com/content/pdf/10.1007/s12105-022-01448-3.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://link.springer.com/content/pdf/10.1007/s12105-022-01448-3.pdfDirect OA link when available
- Concepts
-
Mucoepidermoid carcinoma, Mucin, MUC1, Adenoid cystic carcinoma, Salivary duct carcinoma, Medicine, Salivary gland, Immunohistochemistry, Pathology, Carcinoma, Submandibular gland, Lymphovascular invasion, Sublingual gland, Salivary gland cancer, Lymph node, Cancer, Internal medicine, MetastasisTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
4Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1, 2024: 1, 2023: 2Per-year citation counts (last 5 years)
- References (count)
-
42Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.73167852 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |