Extended (10-Day) Real-Time Monitoring by Dexamethasone-Enhanced Microdialysis in the Injured Rat Cortex Article Swipe
Elaine M. Robbins
,
Andrea Jaquins‐Gerstl
,
David F. Fine
,
Chi Leng Leong
,
C. Edward Dixon
,
Amy K. Wagner
,
Martyn G. Boutelle
,
Adrian C. Michael
·
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1021/acschemneuro.9b00145
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1021/acschemneuro.9b00145
Intracerebral microdialysis has proven useful for chemical monitoring in patients following traumatic brain injury. Recent studies in animals, however, have documented that insertion of microdialysis probes into brain tissues initiates a foreign-body response. Within a few days after probe insertion, the foreign body response impedes the use of microdialysis to monitor the K+ and glucose transients associated with spreading depolarization, a potential mechanism for secondary brain injury. Herein, we show that perfusing microdialysis probes with dexamethasone, a potent anti-inflammatory glucocorticoid, suppresses the foreign body response and facilitates the monitoring of spontaneous spreading depolarizations for at least 10 days following controlled cortical injury in the rat. In addition to spreading depolarizations, results of this study suggest that a progressive, apparently permanent, decline in pericontusional interstitial glucose may be an additional sequela of brain injury. This study establishes extended dexamethasone-enhanced microdialysis in the injured rodent cortex as a new paradigm for investigating trauma-induced metabolic crisis.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1021/acschemneuro.9b00145
- OA Status
- green
- Cited By
- 12
- References
- 58
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2951627550
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2951627550Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1021/acschemneuro.9b00145Digital Object Identifier
- Title
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Extended (10-Day) Real-Time Monitoring by Dexamethasone-Enhanced Microdialysis in the Injured Rat CortexWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2019Year of publication
- Publication date
-
2019-06-17Full publication date if available
- Authors
-
Elaine M. Robbins, Andrea Jaquins‐Gerstl, David F. Fine, Chi Leng Leong, C. Edward Dixon, Amy K. Wagner, Martyn G. Boutelle, Adrian C. MichaelList of authors in order
- Landing page
-
https://doi.org/10.1021/acschemneuro.9b00145Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
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https://www.ncbi.nlm.nih.gov/pmc/articles/7341684Direct OA link when available
- Concepts
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Microdialysis, Traumatic brain injury, Dexamethasone, Neuroscience, Medicine, Anesthesia, Glucocorticoid, Cortical spreading depression, Depolarization, Pharmacology, Central nervous system, Biology, Internal medicine, Migraine, PsychiatryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
12Total citation count in OpenAlex
- Citations by year (recent)
-
2024: 2, 2023: 3, 2022: 1, 2021: 3, 2020: 3Per-year citation counts (last 5 years)
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58Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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