Extended and two-staged liver resections in patients with colorectal liver metastases Article Swipe
A.Yu. Navmatulya
,
F.R. Almukhametova
,
A.Е. Tsaregorodtsev
,
A.I. Kuznetsov
,
A.S. Lisitcyn
,
Fedor Moiseenko
,
V.M. Moiseyenko
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.31917/2502111
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.31917/2502111
The questions of liver resection volume in patients with colorectal liver metastases are controversial and solved by specialists differently, taking into account the characteristics of the tumor lesion, the surgeon’s own experience and the technical capabilities of the clinic. On the basis of the abdominal department of Saint-Petersburg clinical scientific and practical center for specialized types of medical care (oncological) of N.P. Napalkov, we conducted a retrospective analysis of the long-term outcomes of 106 patients with colorectal liver metastases after extended (n=39) and minor (n=67) liver resections. The median of time-to-progression (TTP) was 8.0 months (95% CI 5.4–10.5) after extended and 11.2 months (95% CI 6.0-16.4) after minor liver resections. There was a tendency towards an increase in median overall survival (OS) for minor resections to 48.9 months (95% CI 31.5–66.4) compared with 33.4 months (95% CI 26.2–40.5) after extended resections. The rate of repeat resections in case of disease recurrence was higher in the minor resection group. When comparing the R0 and R1 resection groups, it was noted that the median OS was not significantly different (49.1 vs 40.8 months, 95% CI 25.7–72.5) despite an increase in TTP in patients with negative resection margins (10.8 vs 7.4 months, 95% CI 25.7–72.5). Thus, according to the analysis of long-term outcomes, no advantages were identified in performing minor interventions compared to extended liver resections, despite the obviously more unfavorable prognosis for massive metastatic liver disease.
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- Type
- article
- Language
- en
- Landing Page
- http://doi.org/10.31917/2502111
- https://doi.org/10.31917/2502111
- OA Status
- diamond
- References
- 12
- Related Works
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- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4400684896Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.31917/2502111Digital Object Identifier
- Title
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Extended and two-staged liver resections in patients with colorectal liver metastasesWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
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2024-06-30Full publication date if available
- Authors
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A.Yu. Navmatulya, F.R. Almukhametova, A.Е. Tsaregorodtsev, A.I. Kuznetsov, A.S. Lisitcyn, Fedor Moiseenko, V.M. MoiseyenkoList of authors in order
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https://doi.org/10.31917/2502111Publisher landing page
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https://doi.org/10.31917/2502111Direct link to full text PDF
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YesWhether a free full text is available
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diamondOpen access status per OpenAlex
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https://doi.org/10.31917/2502111Direct OA link when available
- Concepts
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Medicine, General surgery, Colorectal cancer, Hepatectomy, Surgery, Resection, Internal medicine, CancerTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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