Extended diagnosis of purine and pyrimidine disorders from urine: LC MS/MS assay development and clinical validation Article Swipe
Péter Monostori
,
Glynis Klinke
,
Jana Hauke
,
Sylvia Richter
,
Jörgen Bierau
,
Sven F. Garbade
,
Georg F. Hoffmann
,
Claus‐Dieter Langhans
,
Dorothea Haas
,
Jürgen G. Okun
·
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1371/journal.pone.0212458
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1371/journal.pone.0212458
A LC-MS/MS assay allowing the simultaneous, sensitive and reliable diagnosis of an extended range of purine and pyrimidine disorders has been developed. The validated method has successfully been tested using ERNDIM Diagnostic Proficiency Testing (DPT) samples and further clinical specimens from patients with various purine and pyrimidine disorders. Sample preparation is simple and assay duration is short, facilitating an easier inclusion of the assay into the diagnostic procedures.
Related Topics
Concepts
Purine
Pyrimidine metabolism
Analyte
Medicine
Urine
Purine metabolism
Chromatography
Internal medicine
Chemistry
Biochemistry
Enzyme
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1371/journal.pone.0212458
- https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0212458&type=printable
- OA Status
- gold
- Cited By
- 30
- References
- 27
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2918936363
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2918936363Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1371/journal.pone.0212458Digital Object Identifier
- Title
-
Extended diagnosis of purine and pyrimidine disorders from urine: LC MS/MS assay development and clinical validationWork title
- Type
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articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2019Year of publication
- Publication date
-
2019-02-28Full publication date if available
- Authors
-
Péter Monostori, Glynis Klinke, Jana Hauke, Sylvia Richter, Jörgen Bierau, Sven F. Garbade, Georg F. Hoffmann, Claus‐Dieter Langhans, Dorothea Haas, Jürgen G. OkunList of authors in order
- Landing page
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https://doi.org/10.1371/journal.pone.0212458Publisher landing page
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0212458&type=printableDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0212458&type=printableDirect OA link when available
- Concepts
-
Purine, Pyrimidine metabolism, Analyte, Medicine, Urine, Purine metabolism, Chromatography, Internal medicine, Chemistry, Biochemistry, EnzymeTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
30Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 3, 2024: 6, 2023: 5, 2022: 9, 2021: 3Per-year citation counts (last 5 years)
- References (count)
-
27Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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