Extension of the BIANCA biophysical model up to Fe-ions and applications for space radiation research Article Swipe
Ricardo Luis Ramos
,
A. Embriaco
,
Mario Pietro Carante
,
A. Ferrari
,
P. Sala
,
V. Vercesi
,
and Francesca Ballarini
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1051/epjconf/202226103001
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1051/epjconf/202226103001
BIANCA (BIophysical ANalysis of Cell death and chromosome Aberrations) is a biophysical model, implemented as a Monte Carlo code, which simulates the induction of chromosome aberrations and cell death by different monochromatic ion beams (i.e., different ion types and energy values), as well as photons. In previous works, the model predictions for cell survival and lymphocyte dicentrics along therapeutic-like ion beams have been successfully benchmarked against experimental data. With the aim of evaluating the biological damage induced by Galactic Cosmic Rays (GCR), in this study BIANCA was extended up to Fe-ions. A radiobiological database describing human skin fibroblast cell survival and lymphocyte dicentrics as a function of ion type (1≤Z≤26) and energy, as well as dose, was constructed. Afterwards, interfacing BIANCA with the FLUKA Monte Carlo transport code, a feasibility study was performed to calculate the Relative Biological Effectiveness (RBE) of Galactic Cosmic Rays, both for dicentrics and for cell survival; the results were discussed with respect to available space radiation protection limits. Following this work, BIANCA can now provide RBE predictions of cell killing, which can be related to deterministic effects, and lymphocyte dicentrics, more related to stochastic effects, for space radiation exposure.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1051/epjconf/202226103001
- https://www.epj-conferences.org/articles/epjconf/pdf/2022/05/epjconf_anpc2022_03001.pdf
- OA Status
- diamond
- Cited By
- 4
- References
- 12
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4225573206
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4225573206Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1051/epjconf/202226103001Digital Object Identifier
- Title
-
Extension of the BIANCA biophysical model up to Fe-ions and applications for space radiation researchWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
-
2022-01-01Full publication date if available
- Authors
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Ricardo Luis Ramos, A. Embriaco, Mario Pietro Carante, A. Ferrari, P. Sala, V. Vercesi, and Francesca BallariniList of authors in order
- Landing page
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https://doi.org/10.1051/epjconf/202226103001Publisher landing page
- PDF URL
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https://www.epj-conferences.org/articles/epjconf/pdf/2022/05/epjconf_anpc2022_03001.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
diamondOpen access status per OpenAlex
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https://www.epj-conferences.org/articles/epjconf/pdf/2022/05/epjconf_anpc2022_03001.pdfDirect OA link when available
- Concepts
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Relative biological effectiveness, Cosmic ray, Monte Carlo method, Physics, Space radiation, Ionizing radiation, Linear energy transfer, Radiobiology, Photon, Radiation, Nuclear physics, Computational physics, Irradiation, Optics, Statistics, MathematicsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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4Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1, 2024: 1, 2023: 2Per-year citation counts (last 5 years)
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12Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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