Extracellular Vesicles as Central Mediators of COPD Pathophysiology Article Swipe

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Derek W. Russell , Kristopher R. Genschmer , J. Edwin Blalock ·

YOU? · · 2021 · Open Access · · DOI: https://doi.org/10.1146/annurev-physiol-061121-035838

Chronic obstructive pulmonary disease (COPD) is a complex, heterogeneous, smoking-related disease of significant global impact. The complex biology of COPD is ultimately driven by a few interrelated processes, including proteolytic tissue remodeling, innate immune inflammation, derangements of the host-pathogen response, aberrant cellular phenotype switching, and cellular senescence, among others. Each of these processes are engendered and perpetuated by cells modulating their environment or each other. Extracellular vesicles (EVs) are powerful effectors that allow cells to perform a diverse array of functions on both adjacent and distant tissues, and their pleiotropic nature is only beginning to be appreciated. As such, EVs are candidates to play major roles in these fundamental mechanisms of disease behind COPD. Furthermore, some such roles for EVs are already established, and EVs are implicated in significant aspects of COPD pathogenesis. Here, we discuss known and potential ways that EVs modulate the environment of their originating cells to contribute to the processes that underlie COPD.

Related Topics

Chronic Obstructive Pulmonary Disease

Multicellular Organism

Concepts

Extracellular vesicles COPD Inflammation Pathogenesis Effector Immune system Innate immune system Biology Immunology Microvesicles Disease Cell biology Tissue remodeling Pulmonary disease Extracellular Phenotype Multicellular organism Pathophysiology Neuroscience microRNA Medicine Cell Genetics Pathology Internal medicine Endocrinology Psychiatry Gene

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Type: review
Language: en
Landing Page: https://doi.org/10.1146/annurev-physiol-061121-035838
PDF: https://www.annualreviews.org/doi/pdf/10.1146/annurev-physiol-061121-035838
OA Status: bronze
Cited By: 33
References: 160
Related Works: 10
OpenAlex ID: https://openalex.org/W3208495155

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OpenAlex ID: https://openalex.org/W3208495155

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DOI: https://doi.org/10.1146/annurev-physiol-061121-035838

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Title: Extracellular Vesicles as Central Mediators of COPD Pathophysiology

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Type: review

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Language: en

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Publication year: 2021

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Publication date: 2021-11-01

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Authors: Derek W. Russell, Kristopher R. Genschmer, J. Edwin Blalock

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Landing page: https://doi.org/10.1146/annurev-physiol-061121-035838

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PDF URL: https://www.annualreviews.org/doi/pdf/10.1146/annurev-physiol-061121-035838

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OA status: bronze

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Concepts: Extracellular vesicles, COPD, Inflammation, Pathogenesis, Effector, Immune system, Innate immune system, Biology, Immunology, Microvesicles, Disease, Cell biology, Tissue remodeling, Pulmonary disease, Extracellular, Phenotype, Multicellular organism, Pathophysiology, Neuroscience, microRNA, Medicine, Cell, Genetics, Pathology, Internal medicine, Endocrinology, Psychiatry, Gene

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Cited by: 33

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Citations by year (recent): 2025: 2, 2024: 9, 2023: 3, 2022: 19

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References (count): 160

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Related works (count): 10

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