Extracellular vesicles derived from lung M2 macrophages enhance group 2 innate lymphoid cells function in allergic airway inflammation Article Swipe
Weiya Pei
,
Kun Lv
,
Yingying Zhang
,
Guoquan Yin
,
Xueqin Li
,
Min Zhong
,
Xiaolong Zhu
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-5613639/v1
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-5613639/v1
Group 2 innate lymphoid cells (ILC2s) promote the recruitment of eosinophils by secreting large amounts of type 2 cytokines (IL-5 and IL-13), thus triggering the main feature of asthma, pathological inflammation. Recent insights from mouse and human studies indicated a potential relationship between ILC2s and macrophages. However, the mechanism by which lung M2 macrophage-derived extracellular vesicles (M2 EVs) regulate ILC2s remains unclear. Here, the size, morphology, and specific markers of M2 EVs were successfully characterized in the lungs. Furthermore, we discovered that M2 EVs strongly promoted type 2 lung immunopathology induced by papain. Mechanistically, M2 EVs were internalized by ILC2s, triggering ILC2 activation and inducing pro-inflammatory cytokine (IL-5 and IL-13) production. M2 EVs also indirectly enhanced the function of ILC2s through macrophages and CD4+ T cells. Using RNA sequencing, we found that long non-coding RNA (lncRNA) 4930474H06Rik participated in mediating these effects of M2 EVs. Inhibition of 4930474H06Rik altered intracellular metabolism of activated ILC2s and enhanced NF-κB pathway signaling. Taken together, we demonstrated that M2 EVs promoted allergic airway inflammation at least partially through 4930474H06Rik, implying that 4930474H06Rik can be considered as a therapeutic target for ILC2s activation in allergic airway inflammation.
Related Topics
Concepts
Innate lymphoid cell
Inflammation
Allergic inflammation
Immunology
Interleukin 33
Interleukin 13
Cytokine
Extracellular
Extracellular vesicle
Biology
Cell biology
Innate immune system
Interleukin 4
Immune system
Interleukin
microRNA
Microvesicles
Gene
Biochemistry
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.21203/rs.3.rs-5613639/v1
- OA Status
- gold
- References
- 47
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4405726407
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4405726407Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.21203/rs.3.rs-5613639/v1Digital Object Identifier
- Title
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Extracellular vesicles derived from lung M2 macrophages enhance group 2 innate lymphoid cells function in allergic airway inflammationWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-12-23Full publication date if available
- Authors
-
Weiya Pei, Kun Lv, Yingying Zhang, Guoquan Yin, Xueqin Li, Min Zhong, Xiaolong ZhuList of authors in order
- Landing page
-
https://doi.org/10.21203/rs.3.rs-5613639/v1Publisher landing page
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.21203/rs.3.rs-5613639/v1Direct OA link when available
- Concepts
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Innate lymphoid cell, Inflammation, Allergic inflammation, Immunology, Interleukin 33, Interleukin 13, Cytokine, Extracellular, Extracellular vesicle, Biology, Cell biology, Innate immune system, Interleukin 4, Immune system, Interleukin, microRNA, Microvesicles, Gene, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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47Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| publication_date | 2024-12-23 |
| publication_year | 2024 |
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