Extracellular vesicles engineered to bind albumin demonstrate extended circulation time and lymph node accumulation in mouse models Article Swipe
Xiuming Liang
,
Zheyu Niu
,
Valentina Galli
,
Nathalie Howe
,
Ying Zhao
,
Oscar P. B. Wiklander
,
Wenyi Zheng
,
Rim Jawad Wiklander
,
Giulia Corso
,
Christopher J. Davies
,
Justin Hean
,
Eleni Kyriakopoulou
,
Doste R. Mamand
,
Risul Amin
,
Joel Z. Nordin
,
Dhanu Gupta
,
Samir EL Andaloussi
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1002/jev2.12248
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1002/jev2.12248
Extracellular vesicles (EVs) have shown promise as potential therapeutics for the treatment of various diseases. However, their rapid clearance after administration could be a limitation in certain therapeutic settings. To solve this, an engineering strategy is employed to decorate albumin onto the surface of the EVs through surface display of albumin binding domains (ABDs). ABDs were either included in the extracellular loops of select EV‐enriched tetraspanins (CD63, CD9 and CD81) or directly fused to the extracellular terminal of single transmembrane EV‐sorting domains, such as Lamp2B. These engineered EVs exert robust binding capacity to human serum albumins (HSA) in vitro and mouse serum albumins (MSA) after injection in mice. By binding to MSA, circulating time of EVs dramatically increases after different routes of injection in different strains of mice. Moreover, these engineered EVs show considerable lymph node (LN) and solid tumour accumulation, which can be utilized when using EVs for immunomodulation, cancer‐ and/or immunotherapy. The increased circulation time of EVs may also be important when combined with tissue‐specific targeting ligands and could provide significant benefit for their therapeutic use in a variety of disease indications.
Related Topics
Concepts
Microvesicle
Extracellular vesicles
Extracellular vesicle
Extracellular
Exosome
Microvesicles
Albumin
Cell biology
Transmembrane protein
Chemistry
Human serum albumin
Lymph node
Biology
Biochemistry
Immunology
Receptor
Gene
microRNA
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/jev2.12248
- OA Status
- gold
- Cited By
- 73
- References
- 60
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4287848953
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4287848953Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1002/jev2.12248Digital Object Identifier
- Title
-
Extracellular vesicles engineered to bind albumin demonstrate extended circulation time and lymph node accumulation in mouse modelsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-06-01Full publication date if available
- Authors
-
Xiuming Liang, Zheyu Niu, Valentina Galli, Nathalie Howe, Ying Zhao, Oscar P. B. Wiklander, Wenyi Zheng, Rim Jawad Wiklander, Giulia Corso, Christopher J. Davies, Justin Hean, Eleni Kyriakopoulou, Doste R. Mamand, Risul Amin, Joel Z. Nordin, Dhanu Gupta, Samir EL AndaloussiList of authors in order
- Landing page
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https://doi.org/10.1002/jev2.12248Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1002/jev2.12248Direct OA link when available
- Concepts
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Microvesicle, Extracellular vesicles, Extracellular vesicle, Extracellular, Exosome, Microvesicles, Albumin, Cell biology, Transmembrane protein, Chemistry, Human serum albumin, Lymph node, Biology, Biochemistry, Immunology, Receptor, Gene, microRNATop concepts (fields/topics) attached by OpenAlex
- Cited by
-
73Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 29, 2024: 23, 2023: 18, 2022: 3Per-year citation counts (last 5 years)
- References (count)
-
60Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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