Extracellular vesicles from mesenchymal stromal cells: an emerging therapy for intractable neonatal disorders Article Swipe
Sein Hwang
,
Young‐Eun Kim
,
Misun Yang
,
So Yoon Ahn
,
Se In Sung
,
Yun Sil Chang
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1093/stcltm/szaf050
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1093/stcltm/szaf050
Neonatal disorders affecting different organs are highly multifactorial and involve a complex interplay among prematurity, inflammation, oxidative stress, tissue injury, immune dysregulation, and impaired regeneration. Conditions such as hypoxic-ischemic encephalopathy, intraventricular hemorrhage, neonatal stroke, bronchopulmonary dysplasia, and necrotizing enterocolitis often result from or cause multi-organ dysfunction. This multifaceted nature presents a substantial therapeutic challenge, as current treatment plans are largely supportive and are limited to addressing the underlying immaturity and injury. Mesenchymal stromal cell-derived extracellular vesicles (MSC-EVs) have emerged as promising cell-free therapeutics owing to their ability to modulate inflammation, promote repair, and support organ maturation. By delivering a rich secretome of proteins, lipids, and regulatory RNAs, MSC-EVs retain the regenerative benefits of mesenchymal stromal cells while offering improved safety and storage. This review provides a comprehensive overview of MSC-EV therapy for neonatal disorders, focusing on the mechanisms of action, preclinical evidence, and future perspectives on clinical translation. By integrating the currently available study findings, this review highlights the potential of MSC-EVs as a multifaceted therapy for preterm infants, capable of addressing both tissue injury and developmental immaturity.
Related Topics
Concepts
No concepts available.
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1093/stcltm/szaf050
- OA Status
- gold
- References
- 129
- OpenAlex ID
- https://openalex.org/W4416057031
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4416057031Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1093/stcltm/szaf050Digital Object Identifier
- Title
-
Extracellular vesicles from mesenchymal stromal cells: an emerging therapy for intractable neonatal disordersWork title
- Type
-
reviewOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-09-28Full publication date if available
- Authors
-
Sein Hwang, Young‐Eun Kim, Misun Yang, So Yoon Ahn, Se In Sung, Yun Sil ChangList of authors in order
- Landing page
-
https://doi.org/10.1093/stcltm/szaf050Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1093/stcltm/szaf050Direct OA link when available
- Cited by
-
0Total citation count in OpenAlex
- References (count)
-
129Number of works referenced by this work
Full payload
| id | https://openalex.org/W4416057031 |
|---|---|
| doi | https://doi.org/10.1093/stcltm/szaf050 |
| ids.doi | https://doi.org/10.1093/stcltm/szaf050 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/41207717 |
| ids.openalex | https://openalex.org/W4416057031 |
| fwci | 0.0 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D006801 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Humans |
| mesh[1].qualifier_ui | Q000637 |
| mesh[1].descriptor_ui | D000067128 |
| mesh[1].is_major_topic | True |
| mesh[1].qualifier_name | transplantation |
| mesh[1].descriptor_name | Extracellular Vesicles |
| mesh[2].qualifier_ui | Q000378 |
| mesh[2].descriptor_ui | D000067128 |
| mesh[2].is_major_topic | True |
| mesh[2].qualifier_name | metabolism |
| mesh[2].descriptor_name | Extracellular Vesicles |
| mesh[3].qualifier_ui | Q000378 |
| mesh[3].descriptor_ui | D059630 |
| mesh[3].is_major_topic | True |
| mesh[3].qualifier_name | metabolism |
| mesh[3].descriptor_name | Mesenchymal Stem Cells |
| mesh[4].qualifier_ui | Q000166 |
| mesh[4].descriptor_ui | D059630 |
| mesh[4].is_major_topic | True |
| mesh[4].qualifier_name | cytology |
| mesh[4].descriptor_name | Mesenchymal Stem Cells |
| mesh[5].qualifier_ui | |
| mesh[5].descriptor_ui | D007231 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | |
| mesh[5].descriptor_name | Infant, Newborn |
| mesh[6].qualifier_ui | Q000628 |
| mesh[6].descriptor_ui | D007232 |
| mesh[6].is_major_topic | True |
| mesh[6].qualifier_name | therapy |
| mesh[6].descriptor_name | Infant, Newborn, Diseases |
| mesh[7].qualifier_ui | Q000379 |
| mesh[7].descriptor_ui | D045164 |
| mesh[7].is_major_topic | True |
| mesh[7].qualifier_name | methods |
| mesh[7].descriptor_name | Mesenchymal Stem Cell Transplantation |
| mesh[8].qualifier_ui | |
| mesh[8].descriptor_ui | D000818 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | |
| mesh[8].descriptor_name | Animals |
| mesh[9].qualifier_ui | |
| mesh[9].descriptor_ui | D007234 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | |
| mesh[9].descriptor_name | Infant, Premature |
| type | review |
| title | Extracellular vesicles from mesenchymal stromal cells: an emerging therapy for intractable neonatal disorders |
| biblio.issue | 10 |
| biblio.volume | 14 |
| biblio.last_page | |
| biblio.first_page | |
| is_xpac | False |
| apc_list.value | 2688 |
| apc_list.currency | USD |
| apc_list.value_usd | 2688 |
| apc_paid.value | 2688 |
| apc_paid.currency | USD |
| apc_paid.value_usd | 2688 |
| language | en |
| locations[0].id | doi:10.1093/stcltm/szaf050 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S2494728167 |
| locations[0].source.issn | 2157-6564, 2157-6580 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 2157-6564 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Stem Cells Translational Medicine |
| locations[0].source.host_organization | https://openalex.org/P4310320595 |
| locations[0].source.host_organization_name | Wiley |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320595 |
| locations[0].license | |
| locations[0].pdf_url | |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Stem Cells Translational Medicine |
| locations[0].landing_page_url | https://doi.org/10.1093/stcltm/szaf050 |
| locations[1].id | pmid:41207717 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Stem cells translational medicine |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/41207717 |
| locations[2].id | pmh:oai:europepmc.org:11406012 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S4306400806 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | Europe PMC (PubMed Central) |
| locations[2].source.host_organization | https://openalex.org/I1303153112 |
| locations[2].source.host_organization_name | European Bioinformatics Institute |
| locations[2].source.host_organization_lineage | https://openalex.org/I1303153112 |
| locations[2].license | cc-by-nc |
| locations[2].pdf_url | https://pmc.ncbi.nlm.nih.gov/articles/PMC12597145/pdf/szaf050.pdf |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | https://openalex.org/licenses/cc-by-nc |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/12597145 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5102656712 |
| authorships[0].author.orcid | https://orcid.org/0009-0007-0429-6709 |
| authorships[0].author.display_name | Sein Hwang |
| authorships[0].countries | KR |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I2802194831 |
| authorships[0].affiliations[0].raw_affiliation_string | Cell and Gene Therapy Institute for Future Medicine, Samsung Medical Center , Seoul 06351, |
| authorships[0].institutions[0].id | https://openalex.org/I2802194831 |
| authorships[0].institutions[0].ror | https://ror.org/05a15z872 |
| authorships[0].institutions[0].type | healthcare |
| authorships[0].institutions[0].lineage | https://openalex.org/I2250650973, https://openalex.org/I2802194831 |
| authorships[0].institutions[0].country_code | KR |
| authorships[0].institutions[0].display_name | Samsung Medical Center |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Sein Hwang |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Cell and Gene Therapy Institute for Future Medicine, Samsung Medical Center , Seoul 06351, |
| authorships[1].author.id | https://openalex.org/A5100455090 |
| authorships[1].author.orcid | https://orcid.org/0000-0003-0694-6844 |
| authorships[1].author.display_name | Young‐Eun Kim |
| authorships[1].countries | KR |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I2802194831 |
| authorships[1].affiliations[0].raw_affiliation_string | Cell and Gene Therapy Institute for Future Medicine, Samsung Medical Center , Seoul 06351, |
| authorships[1].institutions[0].id | https://openalex.org/I2802194831 |
| authorships[1].institutions[0].ror | https://ror.org/05a15z872 |
| authorships[1].institutions[0].type | healthcare |
| authorships[1].institutions[0].lineage | https://openalex.org/I2250650973, https://openalex.org/I2802194831 |
| authorships[1].institutions[0].country_code | KR |
| authorships[1].institutions[0].display_name | Samsung Medical Center |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Young Eun Kim |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Cell and Gene Therapy Institute for Future Medicine, Samsung Medical Center , Seoul 06351, |
| authorships[2].author.id | https://openalex.org/A5032826481 |
| authorships[2].author.orcid | https://orcid.org/0000-0003-1634-6623 |
| authorships[2].author.display_name | Misun Yang |
| authorships[2].countries | KR |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I2802194831 |
| authorships[2].affiliations[0].raw_affiliation_string | Cell and Gene Therapy Institute for Future Medicine, Samsung Medical Center , Seoul 06351, |
| authorships[2].affiliations[1].institution_ids | https://openalex.org/I848706 |
| authorships[2].affiliations[1].raw_affiliation_string | Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine , Seoul 06351, |
| authorships[2].institutions[0].id | https://openalex.org/I2802194831 |
| authorships[2].institutions[0].ror | https://ror.org/05a15z872 |
| authorships[2].institutions[0].type | healthcare |
| authorships[2].institutions[0].lineage | https://openalex.org/I2250650973, https://openalex.org/I2802194831 |
| authorships[2].institutions[0].country_code | KR |
| authorships[2].institutions[0].display_name | Samsung Medical Center |
| authorships[2].institutions[1].id | https://openalex.org/I848706 |
| authorships[2].institutions[1].ror | https://ror.org/04q78tk20 |
| authorships[2].institutions[1].type | education |
| authorships[2].institutions[1].lineage | https://openalex.org/I848706 |
| authorships[2].institutions[1].country_code | KR |
| authorships[2].institutions[1].display_name | Sungkyunkwan University |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Misun Yang |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Cell and Gene Therapy Institute for Future Medicine, Samsung Medical Center , Seoul 06351,, Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine , Seoul 06351, |
| authorships[3].author.id | https://openalex.org/A5033114360 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-1821-3173 |
| authorships[3].author.display_name | So Yoon Ahn |
| authorships[3].countries | KR |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I2802194831, https://openalex.org/I848706 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine , Seoul 06351, |
| authorships[3].institutions[0].id | https://openalex.org/I2802194831 |
| authorships[3].institutions[0].ror | https://ror.org/05a15z872 |
| authorships[3].institutions[0].type | healthcare |
| authorships[3].institutions[0].lineage | https://openalex.org/I2250650973, https://openalex.org/I2802194831 |
| authorships[3].institutions[0].country_code | KR |
| authorships[3].institutions[0].display_name | Samsung Medical Center |
| authorships[3].institutions[1].id | https://openalex.org/I848706 |
| authorships[3].institutions[1].ror | https://ror.org/04q78tk20 |
| authorships[3].institutions[1].type | education |
| authorships[3].institutions[1].lineage | https://openalex.org/I848706 |
| authorships[3].institutions[1].country_code | KR |
| authorships[3].institutions[1].display_name | Sungkyunkwan University |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | So Yoon Ahn |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine , Seoul 06351, |
| authorships[4].author.id | https://openalex.org/A5024269977 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-8717-6142 |
| authorships[4].author.display_name | Se In Sung |
| authorships[4].countries | KR |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I848706 |
| authorships[4].affiliations[0].raw_affiliation_string | Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine , Seoul 06351, |
| authorships[4].affiliations[1].institution_ids | https://openalex.org/I2802194831 |
| authorships[4].affiliations[1].raw_affiliation_string | Cell and Gene Therapy Institute for Future Medicine, Samsung Medical Center , Seoul 06351, |
| authorships[4].institutions[0].id | https://openalex.org/I2802194831 |
| authorships[4].institutions[0].ror | https://ror.org/05a15z872 |
| authorships[4].institutions[0].type | healthcare |
| authorships[4].institutions[0].lineage | https://openalex.org/I2250650973, https://openalex.org/I2802194831 |
| authorships[4].institutions[0].country_code | KR |
| authorships[4].institutions[0].display_name | Samsung Medical Center |
| authorships[4].institutions[1].id | https://openalex.org/I848706 |
| authorships[4].institutions[1].ror | https://ror.org/04q78tk20 |
| authorships[4].institutions[1].type | education |
| authorships[4].institutions[1].lineage | https://openalex.org/I848706 |
| authorships[4].institutions[1].country_code | KR |
| authorships[4].institutions[1].display_name | Sungkyunkwan University |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Se In Sung |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Cell and Gene Therapy Institute for Future Medicine, Samsung Medical Center , Seoul 06351,, Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine , Seoul 06351, |
| authorships[5].author.id | https://openalex.org/A5018338653 |
| authorships[5].author.orcid | https://orcid.org/0000-0001-9201-2938 |
| authorships[5].author.display_name | Yun Sil Chang |
| authorships[5].countries | KR |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I2802194831 |
| authorships[5].affiliations[0].raw_affiliation_string | Cell and Gene Therapy Institute for Future Medicine, Samsung Medical Center , Seoul 06351, |
| authorships[5].affiliations[1].institution_ids | https://openalex.org/I848706 |
| authorships[5].affiliations[1].raw_affiliation_string | Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine , Seoul 06351, |
| authorships[5].institutions[0].id | https://openalex.org/I2802194831 |
| authorships[5].institutions[0].ror | https://ror.org/05a15z872 |
| authorships[5].institutions[0].type | healthcare |
| authorships[5].institutions[0].lineage | https://openalex.org/I2250650973, https://openalex.org/I2802194831 |
| authorships[5].institutions[0].country_code | KR |
| authorships[5].institutions[0].display_name | Samsung Medical Center |
| authorships[5].institutions[1].id | https://openalex.org/I848706 |
| authorships[5].institutions[1].ror | https://ror.org/04q78tk20 |
| authorships[5].institutions[1].type | education |
| authorships[5].institutions[1].lineage | https://openalex.org/I848706 |
| authorships[5].institutions[1].country_code | KR |
| authorships[5].institutions[1].display_name | Sungkyunkwan University |
| authorships[5].author_position | last |
| authorships[5].raw_author_name | Yun Sil Chang |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Cell and Gene Therapy Institute for Future Medicine, Samsung Medical Center , Seoul 06351,, Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine , Seoul 06351, |
| has_content.pdf | False |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://doi.org/10.1093/stcltm/szaf050 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-11-10T00:00:00 |
| display_name | Extracellular vesicles from mesenchymal stromal cells: an emerging therapy for intractable neonatal disorders |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-28T10:37:01.940451 |
| primary_topic | |
| cited_by_count | 0 |
| locations_count | 3 |
| best_oa_location.id | doi:10.1093/stcltm/szaf050 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S2494728167 |
| best_oa_location.source.issn | 2157-6564, 2157-6580 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 2157-6564 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Stem Cells Translational Medicine |
| best_oa_location.source.host_organization | https://openalex.org/P4310320595 |
| best_oa_location.source.host_organization_name | Wiley |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320595 |
| best_oa_location.license | |
| best_oa_location.pdf_url | |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Stem Cells Translational Medicine |
| best_oa_location.landing_page_url | https://doi.org/10.1093/stcltm/szaf050 |
| primary_location.id | doi:10.1093/stcltm/szaf050 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S2494728167 |
| primary_location.source.issn | 2157-6564, 2157-6580 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 2157-6564 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Stem Cells Translational Medicine |
| primary_location.source.host_organization | https://openalex.org/P4310320595 |
| primary_location.source.host_organization_name | Wiley |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320595 |
| primary_location.license | |
| primary_location.pdf_url | |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Stem Cells Translational Medicine |
| primary_location.landing_page_url | https://doi.org/10.1093/stcltm/szaf050 |
| publication_date | 2025-09-28 |
| publication_year | 2025 |
| referenced_works | https://openalex.org/W4211114070, https://openalex.org/W1976478686, https://openalex.org/W2164664134, https://openalex.org/W1973428620, https://openalex.org/W2796493184, https://openalex.org/W2968810602, https://openalex.org/W3043861550, https://openalex.org/W2944196444, https://openalex.org/W4283790506, https://openalex.org/W2030701238, https://openalex.org/W3023928131, https://openalex.org/W2025371271, https://openalex.org/W2150384215, https://openalex.org/W2023627055, https://openalex.org/W2941661312, https://openalex.org/W2113619226, https://openalex.org/W2074084795, https://openalex.org/W2792667030, https://openalex.org/W4402516939, https://openalex.org/W2747456637, https://openalex.org/W4308387673, https://openalex.org/W3207206612, https://openalex.org/W1493043296, https://openalex.org/W4410955725, https://openalex.org/W4401441627, https://openalex.org/W4406499096, https://openalex.org/W2775992000, https://openalex.org/W2766621542, https://openalex.org/W3112806286, https://openalex.org/W2027917639, https://openalex.org/W2084413840, https://openalex.org/W2954153221, https://openalex.org/W2092784594, https://openalex.org/W2889199320, https://openalex.org/W3129734221, https://openalex.org/W2005962589, https://openalex.org/W2600399425, https://openalex.org/W2938080486, https://openalex.org/W3093994822, https://openalex.org/W4212871165, https://openalex.org/W3154375309, https://openalex.org/W4386022878, https://openalex.org/W4379746432, https://openalex.org/W2888109284, https://openalex.org/W2237418288, https://openalex.org/W4391649568, https://openalex.org/W2170852633, https://openalex.org/W4382243229, https://openalex.org/W2930319490, https://openalex.org/W2066234893, https://openalex.org/W3041578319, https://openalex.org/W4392755999, https://openalex.org/W3212227091, https://openalex.org/W4317815040, https://openalex.org/W4385308116, https://openalex.org/W2166370479, https://openalex.org/W2055313665, https://openalex.org/W2922144466, https://openalex.org/W4311255691, https://openalex.org/W4400294003, https://openalex.org/W4388692999, https://openalex.org/W2921050683, https://openalex.org/W2038254536, https://openalex.org/W2090175148, https://openalex.org/W2347148183, https://openalex.org/W2964806815, https://openalex.org/W2925330721, https://openalex.org/W3040656504, https://openalex.org/W3113127697, https://openalex.org/W3119260727, https://openalex.org/W4293428409, https://openalex.org/W3217491403, https://openalex.org/W4220808382, https://openalex.org/W4284666315, https://openalex.org/W4290724838, https://openalex.org/W4205120242, https://openalex.org/W4366221531, https://openalex.org/W4389052188, https://openalex.org/W4393005650, https://openalex.org/W3182849201, https://openalex.org/W3112034088, https://openalex.org/W4285034600, https://openalex.org/W2109912660, https://openalex.org/W1986577473, https://openalex.org/W3106907611, https://openalex.org/W2804849987, https://openalex.org/W2790450361, https://openalex.org/W2120111168, https://openalex.org/W2552379881, https://openalex.org/W3138847539, https://openalex.org/W4385406646, https://openalex.org/W3203866006, https://openalex.org/W2895366538, https://openalex.org/W2798170384, https://openalex.org/W2811208517, https://openalex.org/W2753884258, https://openalex.org/W2885557301, https://openalex.org/W3042532720, https://openalex.org/W3091906536, https://openalex.org/W3106636902, https://openalex.org/W3156101034, https://openalex.org/W3126546613, https://openalex.org/W3208671315, https://openalex.org/W4220786878, https://openalex.org/W4200380264, https://openalex.org/W4283589832, https://openalex.org/W4388684672, https://openalex.org/W4393433613, https://openalex.org/W3202359382, https://openalex.org/W3174493354, https://openalex.org/W2082604867, https://openalex.org/W3095930618, https://openalex.org/W4289521459, https://openalex.org/W2211754517, https://openalex.org/W2765990633, https://openalex.org/W2593243176, https://openalex.org/W4206731013, https://openalex.org/W2592988251, https://openalex.org/W4295745582, https://openalex.org/W2512327724, https://openalex.org/W2292254726, https://openalex.org/W2790447059, https://openalex.org/W3187501038, https://openalex.org/W4400015592, https://openalex.org/W4408053316, https://openalex.org/W4409119623, https://openalex.org/W4403431249, https://openalex.org/W3016496701, https://openalex.org/W4304183732 |
| referenced_works_count | 129 |
| abstract_inverted_index.a | 11, 51, 99, 126, 164 |
| abstract_inverted_index.By | 97, 149 |
| abstract_inverted_index.as | 28, 55, 80, 163 |
| abstract_inverted_index.of | 102, 113, 129, 139, 161, 171 |
| abstract_inverted_index.on | 136, 146 |
| abstract_inverted_index.or | 43 |
| abstract_inverted_index.to | 65, 85, 88 |
| abstract_inverted_index.and | 9, 23, 37, 62, 70, 93, 105, 121, 143, 176 |
| abstract_inverted_index.are | 6, 59, 63 |
| abstract_inverted_index.for | 132, 167 |
| abstract_inverted_index.the | 67, 110, 137, 151, 159 |
| abstract_inverted_index.This | 47, 123 |
| abstract_inverted_index.both | 173 |
| abstract_inverted_index.from | 42 |
| abstract_inverted_index.have | 78 |
| abstract_inverted_index.rich | 100 |
| abstract_inverted_index.such | 27 |
| abstract_inverted_index.this | 156 |
| abstract_inverted_index.RNAs, | 107 |
| abstract_inverted_index.among | 14 |
| abstract_inverted_index.cause | 44 |
| abstract_inverted_index.cells | 116 |
| abstract_inverted_index.often | 40 |
| abstract_inverted_index.organ | 95 |
| abstract_inverted_index.owing | 84 |
| abstract_inverted_index.plans | 58 |
| abstract_inverted_index.study | 154 |
| abstract_inverted_index.their | 86 |
| abstract_inverted_index.while | 117 |
| abstract_inverted_index.MSC-EV | 130 |
| abstract_inverted_index.future | 144 |
| abstract_inverted_index.highly | 7 |
| abstract_inverted_index.immune | 21 |
| abstract_inverted_index.injury | 175 |
| abstract_inverted_index.nature | 49 |
| abstract_inverted_index.organs | 5 |
| abstract_inverted_index.result | 41 |
| abstract_inverted_index.retain | 109 |
| abstract_inverted_index.review | 124, 157 |
| abstract_inverted_index.safety | 120 |
| abstract_inverted_index.tissue | 19, 174 |
| abstract_inverted_index.MSC-EVs | 108, 162 |
| abstract_inverted_index.ability | 87 |
| abstract_inverted_index.action, | 140 |
| abstract_inverted_index.capable | 170 |
| abstract_inverted_index.complex | 12 |
| abstract_inverted_index.current | 56 |
| abstract_inverted_index.emerged | 79 |
| abstract_inverted_index.injury, | 20 |
| abstract_inverted_index.injury. | 71 |
| abstract_inverted_index.involve | 10 |
| abstract_inverted_index.largely | 60 |
| abstract_inverted_index.limited | 64 |
| abstract_inverted_index.lipids, | 104 |
| abstract_inverted_index.preterm | 168 |
| abstract_inverted_index.promote | 91 |
| abstract_inverted_index.repair, | 92 |
| abstract_inverted_index.stress, | 18 |
| abstract_inverted_index.stroke, | 34 |
| abstract_inverted_index.stromal | 73, 115 |
| abstract_inverted_index.support | 94 |
| abstract_inverted_index.therapy | 131, 166 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.Neonatal | 1 |
| abstract_inverted_index.benefits | 112 |
| abstract_inverted_index.clinical | 147 |
| abstract_inverted_index.focusing | 135 |
| abstract_inverted_index.impaired | 24 |
| abstract_inverted_index.improved | 119 |
| abstract_inverted_index.infants, | 169 |
| abstract_inverted_index.modulate | 89 |
| abstract_inverted_index.neonatal | 33, 133 |
| abstract_inverted_index.offering | 118 |
| abstract_inverted_index.overview | 128 |
| abstract_inverted_index.presents | 50 |
| abstract_inverted_index.provides | 125 |
| abstract_inverted_index.storage. | 122 |
| abstract_inverted_index.vesicles | 76 |
| abstract_inverted_index.(MSC-EVs) | 77 |
| abstract_inverted_index.affecting | 3 |
| abstract_inverted_index.available | 153 |
| abstract_inverted_index.cell-free | 82 |
| abstract_inverted_index.currently | 152 |
| abstract_inverted_index.different | 4 |
| abstract_inverted_index.disorders | 2 |
| abstract_inverted_index.evidence, | 142 |
| abstract_inverted_index.findings, | 155 |
| abstract_inverted_index.interplay | 13 |
| abstract_inverted_index.oxidative | 17 |
| abstract_inverted_index.potential | 160 |
| abstract_inverted_index.promising | 81 |
| abstract_inverted_index.proteins, | 103 |
| abstract_inverted_index.secretome | 101 |
| abstract_inverted_index.treatment | 57 |
| abstract_inverted_index.Conditions | 26 |
| abstract_inverted_index.addressing | 66, 172 |
| abstract_inverted_index.challenge, | 54 |
| abstract_inverted_index.delivering | 98 |
| abstract_inverted_index.disorders, | 134 |
| abstract_inverted_index.dysplasia, | 36 |
| abstract_inverted_index.highlights | 158 |
| abstract_inverted_index.immaturity | 69 |
| abstract_inverted_index.mechanisms | 138 |
| abstract_inverted_index.regulatory | 106 |
| abstract_inverted_index.supportive | 61 |
| abstract_inverted_index.underlying | 68 |
| abstract_inverted_index.Mesenchymal | 72 |
| abstract_inverted_index.hemorrhage, | 32 |
| abstract_inverted_index.immaturity. | 178 |
| abstract_inverted_index.integrating | 150 |
| abstract_inverted_index.maturation. | 96 |
| abstract_inverted_index.mesenchymal | 114 |
| abstract_inverted_index.multi-organ | 45 |
| abstract_inverted_index.necrotizing | 38 |
| abstract_inverted_index.preclinical | 141 |
| abstract_inverted_index.substantial | 52 |
| abstract_inverted_index.therapeutic | 53 |
| abstract_inverted_index.cell-derived | 74 |
| abstract_inverted_index.dysfunction. | 46 |
| abstract_inverted_index.multifaceted | 48, 165 |
| abstract_inverted_index.perspectives | 145 |
| abstract_inverted_index.prematurity, | 15 |
| abstract_inverted_index.regenerative | 111 |
| abstract_inverted_index.therapeutics | 83 |
| abstract_inverted_index.translation. | 148 |
| abstract_inverted_index.comprehensive | 127 |
| abstract_inverted_index.developmental | 177 |
| abstract_inverted_index.enterocolitis | 39 |
| abstract_inverted_index.extracellular | 75 |
| abstract_inverted_index.inflammation, | 16, 90 |
| abstract_inverted_index.regeneration. | 25 |
| abstract_inverted_index.dysregulation, | 22 |
| abstract_inverted_index.multifactorial | 8 |
| abstract_inverted_index.encephalopathy, | 30 |
| abstract_inverted_index.bronchopulmonary | 35 |
| abstract_inverted_index.hypoxic-ischemic | 29 |
| abstract_inverted_index.intraventricular | 31 |
| cited_by_percentile_year | |
| countries_distinct_count | 1 |
| institutions_distinct_count | 6 |
| citation_normalized_percentile |