Extrachromosomal DNA: shaping the evolutionary dynamics of cancer Article Swipe
Magnus Haughey
,
Imran Noorani
,
Charles Swanton
,
Paul S. Mischel
,
Benjamin Werner
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1016/j.trecan.2025.06.004
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1016/j.trecan.2025.06.004
Cancers are complex, diverse, and elusive, with extrachromosomal DNA (ecDNA) recently emerging as a crucial player in driving the evolution of about 20% of all tumors. In this review we discuss open questions concerning the evolutionary role of ecDNA in tumor development, including tumorigenesis and metastatic seeding, the mutational landscape on ecDNA, the dynamic ecDNA genotype-phenotype map, the structural evolution of ecDNA, and how knowledge of tissue-specific ecDNA evolutionary paths can be leveraged to deliver more effective clinical treatment. Looking forward, evolutionary theoretical modeling will be instrumental in advancing new research in the field, and we explore how modeling has contributed to our understanding of the evolutionary principles governing ecDNA dynamics. Ultimately, these challenges must be tackled to improve clinical stratification and create tumor- and patient-specific ecDNA-based therapies.
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- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.trecan.2025.06.004
- https://www.cell.com/trends/cancer/pdf/S2405-8033(25)00146-3.pdf
- OA Status
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- Cited By
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- References
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- Related Works
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- OpenAlex ID
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Extrachromosomal DNA: shaping the evolutionary dynamics of cancerWork title
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reviewOpenAlex work type
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enPrimary language
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2025Year of publication
- Publication date
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2025-07-15Full publication date if available
- Authors
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Magnus Haughey, Imran Noorani, Charles Swanton, Paul S. Mischel, Benjamin WernerList of authors in order
- Landing page
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https://doi.org/10.1016/j.trecan.2025.06.004Publisher landing page
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https://www.cell.com/trends/cancer/pdf/S2405-8033(25)00146-3.pdfDirect link to full text PDF
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hybridOpen access status per OpenAlex
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https://www.cell.com/trends/cancer/pdf/S2405-8033(25)00146-3.pdfDirect OA link when available
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Evolutionary biology, Evolutionary dynamics, Extrachromosomal DNA, Biology, Computational biology, Computer science, Medicine, Genetics, Genome, Population, Gene, Environmental healthTop concepts (fields/topics) attached by OpenAlex
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1Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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