Extrinsic sialylation is dynamically regulated by systemic triggers in vivo Article Swipe
Charles Manhardt
,
Patrick R. Punch
,
Christopher W.L. Dougher
,
Joseph T.Y. Lau
·
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1074/jbc.c117.795138
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1074/jbc.c117.795138
Recent reports have documented that extracellular sialyltransferases can remodel both cell-surface and secreted glycans by a process other than the canonical cell-autonomous glycosylation that occurs within the intracellular secretory apparatus. Despite association of the abundance of these extracellular sialyltransferases, particularly ST6Gal-1, with disease states such as cancer and a variety of inflammatory conditions, the prevalence of this extrinsic glycosylation pathway in vivo remains unknown. Here we observed no significant extrinsic sialylation in resting mice, suggesting that extrinsic sialylation is not a constitutive process. However, extrinsic sialylation in the periphery could be triggered by inflammatory challenges, such as exposure to ionizing radiation or to bacterial lipopolysaccharides. Sialic acids from circulating platelets were used in vivo to remodel target cell surfaces. Platelet activation was minimally sufficient to elicit extrinsic sialylation, as demonstrated with the FeCl3 model of mesenteric artery thrombosis. Although extracellular ST6Gal-1 supports extrinsic sialylation, other sialyltransferases are present in systemic circulation. We also observed in vivo extrinsic sialylation in animals deficient in ST6Gal-1, demonstrating that extrinsic sialylation is not mediated exclusively by ST6Gal-1. Together, these observations form an emerging picture of glycans biosynthesized by the canonical cell-autonomous glycosylation pathway, but subjected to remodeling by extracellular glycan-modifying enzymes.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1074/jbc.c117.795138
- http://www.jbc.org/article/S0021925820343398/pdf
- OA Status
- hybrid
- Cited By
- 56
- References
- 38
- Related Works
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- OpenAlex ID
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https://openalex.org/W2735691045Canonical identifier for this work in OpenAlex
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https://doi.org/10.1074/jbc.c117.795138Digital Object Identifier
- Title
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Extrinsic sialylation is dynamically regulated by systemic triggers in vivoWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2017Year of publication
- Publication date
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2017-07-18Full publication date if available
- Authors
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Charles Manhardt, Patrick R. Punch, Christopher W.L. Dougher, Joseph T.Y. LauList of authors in order
- Landing page
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https://doi.org/10.1074/jbc.c117.795138Publisher landing page
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https://www.jbc.org/article/S0021925820343398/pdfDirect link to full text PDF
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://www.jbc.org/article/S0021925820343398/pdfDirect OA link when available
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In vivo, Cell biology, Systemic risk, Chemistry, Business, Computer science, Biology, Economics, Genetics, Financial crisis, MacroeconomicsTop concepts (fields/topics) attached by OpenAlex
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56Total citation count in OpenAlex
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2025: 2, 2024: 9, 2023: 7, 2022: 7, 2021: 8Per-year citation counts (last 5 years)
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38Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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