Fabrication of hierarchically porous trabecular bone replicas via 3D printing with high internal phase emulsions (HIPEs) Article Swipe
Nihan Sengokmen-Ozsoz
,
Mina Aleemardani
,
Marco Palanca
,
Alice Jane Hann
,
Gwendolen C. Reilly
,
Enrico Dall’Ara
,
Frederik Claeyssens
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1088/1758-5090/ad8b70
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1088/1758-5090/ad8b70
Combining emulsion templating with additive manufacturing enables the production of inherently porous scaffolds with multiscale porosity. This approach incorporates interconnected porous materials, providing a structure that supports cell ingrowth. However, 3D printing hierarchical porous structures that combine semi-micropores and micropores remains a challenging task. Previous studies have demonstrated that using a carefully adjusted combination of light absorbers and photoinitiators in the resin can produce open surface porosity, sponge-like internal structures, and a printing resolution of about 150 µ m. In this study, we explored how varying concentrations of tartrazine (0, 0.02, 0.04, and 0.08 wt%) as a light absorber affect the porous structure of acrylate-based polymerized medium internal phase emulsions fabricated via vat photopolymerization. Given the importance of a porous and interconnected structure for tissue engineering and regenerative medicine, we tested cell behavior on these 3D-printed disk samples using MG-63 cells, examining metabolic activity, adhesion, and morphology. The 0.08 wt% tartrazine-containing 3D-printed sample (008 T) demonstrated the best cell proliferation and adhesion. To show that this high internal phase emulsion (HIPE) resin can be used to create complex structures for biomedical applications, we 3D-printed trabecular bone structures based on microCT imaging. These structures were further evaluated for cell behavior and migration, followed by microCT analysis after 60 days of cell culture. This research demonstrates that HIPEs can be used as a resin to print trabecular bone mimics using additive manufacturing, which could be further developed for lab-on-a-chip models of healthy and diseased bone.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1088/1758-5090/ad8b70
- OA Status
- hybrid
- Cited By
- 12
- References
- 85
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4403756051
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4403756051Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1088/1758-5090/ad8b70Digital Object Identifier
- Title
-
Fabrication of hierarchically porous trabecular bone replicas via 3D printing with high internal phase emulsions (HIPEs)Work title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-10-25Full publication date if available
- Authors
-
Nihan Sengokmen-Ozsoz, Mina Aleemardani, Marco Palanca, Alice Jane Hann, Gwendolen C. Reilly, Enrico Dall’Ara, Frederik ClaeyssensList of authors in order
- Landing page
-
https://doi.org/10.1088/1758-5090/ad8b70Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1088/1758-5090/ad8b70Direct OA link when available
- Concepts
-
Materials science, Fabrication, Porosity, 3D printing, Biomedical engineering, Phase (matter), Composite material, Engineering, Medicine, Chemistry, Pathology, Organic chemistry, Alternative medicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
12Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 12Per-year citation counts (last 5 years)
- References (count)
-
85Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4403756051 |
|---|---|
| doi | https://doi.org/10.1088/1758-5090/ad8b70 |
| ids.doi | https://doi.org/10.1088/1758-5090/ad8b70 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/39454611 |
| ids.openalex | https://openalex.org/W4403756051 |
| fwci | 2.0321301 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D066330 |
| mesh[0].is_major_topic | True |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Printing, Three-Dimensional |
| mesh[1].qualifier_ui | Q000737 |
| mesh[1].descriptor_ui | D004655 |
| mesh[1].is_major_topic | True |
| mesh[1].qualifier_name | chemistry |
| mesh[1].descriptor_name | Emulsions |
| mesh[2].qualifier_ui | |
| mesh[2].descriptor_ui | D016062 |
| mesh[2].is_major_topic | False |
| mesh[2].qualifier_name | |
| mesh[2].descriptor_name | Porosity |
| mesh[3].qualifier_ui | |
| mesh[3].descriptor_ui | D006801 |
| mesh[3].is_major_topic | False |
| mesh[3].qualifier_name | |
| mesh[3].descriptor_name | Humans |
| mesh[4].qualifier_ui | Q000737 |
| mesh[4].descriptor_ui | D054457 |
| mesh[4].is_major_topic | True |
| mesh[4].qualifier_name | chemistry |
| mesh[4].descriptor_name | Tissue Scaffolds |
| mesh[5].qualifier_ui | |
| mesh[5].descriptor_ui | D000071556 |
| mesh[5].is_major_topic | True |
| mesh[5].qualifier_name | |
| mesh[5].descriptor_name | Cancellous Bone |
| mesh[6].qualifier_ui | |
| mesh[6].descriptor_ui | D023822 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | |
| mesh[6].descriptor_name | Tissue Engineering |
| mesh[7].qualifier_ui | |
| mesh[7].descriptor_ui | D045744 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | |
| mesh[7].descriptor_name | Cell Line, Tumor |
| mesh[8].qualifier_ui | Q000187 |
| mesh[8].descriptor_ui | D002448 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | drug effects |
| mesh[8].descriptor_name | Cell Adhesion |
| mesh[9].qualifier_ui | |
| mesh[9].descriptor_ui | D066330 |
| mesh[9].is_major_topic | True |
| mesh[9].qualifier_name | |
| mesh[9].descriptor_name | Printing, Three-Dimensional |
| mesh[10].qualifier_ui | Q000737 |
| mesh[10].descriptor_ui | D004655 |
| mesh[10].is_major_topic | True |
| mesh[10].qualifier_name | chemistry |
| mesh[10].descriptor_name | Emulsions |
| mesh[11].qualifier_ui | |
| mesh[11].descriptor_ui | D016062 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | |
| mesh[11].descriptor_name | Porosity |
| mesh[12].qualifier_ui | |
| mesh[12].descriptor_ui | D006801 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | |
| mesh[12].descriptor_name | Humans |
| mesh[13].qualifier_ui | Q000737 |
| mesh[13].descriptor_ui | D054457 |
| mesh[13].is_major_topic | True |
| mesh[13].qualifier_name | chemistry |
| mesh[13].descriptor_name | Tissue Scaffolds |
| mesh[14].qualifier_ui | |
| mesh[14].descriptor_ui | D000071556 |
| mesh[14].is_major_topic | True |
| mesh[14].qualifier_name | |
| mesh[14].descriptor_name | Cancellous Bone |
| mesh[15].qualifier_ui | |
| mesh[15].descriptor_ui | D023822 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | |
| mesh[15].descriptor_name | Tissue Engineering |
| mesh[16].qualifier_ui | |
| mesh[16].descriptor_ui | D045744 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | |
| mesh[16].descriptor_name | Cell Line, Tumor |
| mesh[17].qualifier_ui | Q000187 |
| mesh[17].descriptor_ui | D002448 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | drug effects |
| mesh[17].descriptor_name | Cell Adhesion |
| type | article |
| title | Fabrication of hierarchically porous trabecular bone replicas via 3D printing with high internal phase emulsions (HIPEs) |
| awards[0].id | https://openalex.org/G1720459405 |
| awards[0].funder_id | https://openalex.org/F4320334627 |
| awards[0].display_name | |
| awards[0].funder_award_id | EP/I007695/1 |
| awards[0].funder_display_name | Engineering and Physical Sciences Research Council |
| awards[1].id | https://openalex.org/G3075507695 |
| awards[1].funder_id | https://openalex.org/F4320334626 |
| awards[1].display_name | |
| awards[1].funder_award_id | MR/L012669/1 |
| awards[1].funder_display_name | Medical Research Council |
| biblio.issue | 1 |
| biblio.volume | 17 |
| biblio.last_page | 015012 |
| biblio.first_page | 015012 |
| topics[0].id | https://openalex.org/T11915 |
| topics[0].field.id | https://openalex.org/fields/25 |
| topics[0].field.display_name | Materials Science |
| topics[0].score | 0.9997000098228455 |
| topics[0].domain.id | https://openalex.org/domains/3 |
| topics[0].domain.display_name | Physical Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2505 |
| topics[0].subfield.display_name | Materials Chemistry |
| topics[0].display_name | Pickering emulsions and particle stabilization |
| topics[1].id | https://openalex.org/T10059 |
| topics[1].field.id | https://openalex.org/fields/22 |
| topics[1].field.display_name | Engineering |
| topics[1].score | 0.9848999977111816 |
| topics[1].domain.id | https://openalex.org/domains/3 |
| topics[1].domain.display_name | Physical Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2204 |
| topics[1].subfield.display_name | Biomedical Engineering |
| topics[1].display_name | Bone Tissue Engineering Materials |
| topics[2].id | https://openalex.org/T10109 |
| topics[2].field.id | https://openalex.org/fields/19 |
| topics[2].field.display_name | Earth and Planetary Sciences |
| topics[2].score | 0.9613999724388123 |
| topics[2].domain.id | https://openalex.org/domains/3 |
| topics[2].domain.display_name | Physical Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/1911 |
| topics[2].subfield.display_name | Paleontology |
| topics[2].display_name | Paleontology and Stratigraphy of Fossils |
| funders[0].id | https://openalex.org/F4320320006 |
| funders[0].ror | https://ror.org/03wnrjx87 |
| funders[0].display_name | Royal Society |
| funders[1].id | https://openalex.org/F4320334626 |
| funders[1].ror | https://ror.org/03x94j517 |
| funders[1].display_name | Medical Research Council |
| funders[2].id | https://openalex.org/F4320334627 |
| funders[2].ror | https://ror.org/0439y7842 |
| funders[2].display_name | Engineering and Physical Sciences Research Council |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C192562407 |
| concepts[0].level | 0 |
| concepts[0].score | 0.822840690612793 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q228736 |
| concepts[0].display_name | Materials science |
| concepts[1].id | https://openalex.org/C136525101 |
| concepts[1].level | 3 |
| concepts[1].score | 0.7522692680358887 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q5428139 |
| concepts[1].display_name | Fabrication |
| concepts[2].id | https://openalex.org/C6648577 |
| concepts[2].level | 2 |
| concepts[2].score | 0.6821331977844238 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q622669 |
| concepts[2].display_name | Porosity |
| concepts[3].id | https://openalex.org/C524769229 |
| concepts[3].level | 2 |
| concepts[3].score | 0.506001889705658 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q229367 |
| concepts[3].display_name | 3D printing |
| concepts[4].id | https://openalex.org/C136229726 |
| concepts[4].level | 1 |
| concepts[4].score | 0.4834462106227875 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q327092 |
| concepts[4].display_name | Biomedical engineering |
| concepts[5].id | https://openalex.org/C44280652 |
| concepts[5].level | 2 |
| concepts[5].score | 0.4649347960948944 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q104837 |
| concepts[5].display_name | Phase (matter) |
| concepts[6].id | https://openalex.org/C159985019 |
| concepts[6].level | 1 |
| concepts[6].score | 0.30537521839141846 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q181790 |
| concepts[6].display_name | Composite material |
| concepts[7].id | https://openalex.org/C127413603 |
| concepts[7].level | 0 |
| concepts[7].score | 0.08256563544273376 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q11023 |
| concepts[7].display_name | Engineering |
| concepts[8].id | https://openalex.org/C71924100 |
| concepts[8].level | 0 |
| concepts[8].score | 0.08003431558609009 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[8].display_name | Medicine |
| concepts[9].id | https://openalex.org/C185592680 |
| concepts[9].level | 0 |
| concepts[9].score | 0.07184833288192749 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[9].display_name | Chemistry |
| concepts[10].id | https://openalex.org/C142724271 |
| concepts[10].level | 1 |
| concepts[10].score | 0.0 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q7208 |
| concepts[10].display_name | Pathology |
| concepts[11].id | https://openalex.org/C178790620 |
| concepts[11].level | 1 |
| concepts[11].score | 0.0 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q11351 |
| concepts[11].display_name | Organic chemistry |
| concepts[12].id | https://openalex.org/C204787440 |
| concepts[12].level | 2 |
| concepts[12].score | 0.0 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q188504 |
| concepts[12].display_name | Alternative medicine |
| keywords[0].id | https://openalex.org/keywords/materials-science |
| keywords[0].score | 0.822840690612793 |
| keywords[0].display_name | Materials science |
| keywords[1].id | https://openalex.org/keywords/fabrication |
| keywords[1].score | 0.7522692680358887 |
| keywords[1].display_name | Fabrication |
| keywords[2].id | https://openalex.org/keywords/porosity |
| keywords[2].score | 0.6821331977844238 |
| keywords[2].display_name | Porosity |
| keywords[3].id | https://openalex.org/keywords/3d-printing |
| keywords[3].score | 0.506001889705658 |
| keywords[3].display_name | 3D printing |
| keywords[4].id | https://openalex.org/keywords/biomedical-engineering |
| keywords[4].score | 0.4834462106227875 |
| keywords[4].display_name | Biomedical engineering |
| keywords[5].id | https://openalex.org/keywords/phase |
| keywords[5].score | 0.4649347960948944 |
| keywords[5].display_name | Phase (matter) |
| keywords[6].id | https://openalex.org/keywords/composite-material |
| keywords[6].score | 0.30537521839141846 |
| keywords[6].display_name | Composite material |
| keywords[7].id | https://openalex.org/keywords/engineering |
| keywords[7].score | 0.08256563544273376 |
| keywords[7].display_name | Engineering |
| keywords[8].id | https://openalex.org/keywords/medicine |
| keywords[8].score | 0.08003431558609009 |
| keywords[8].display_name | Medicine |
| keywords[9].id | https://openalex.org/keywords/chemistry |
| keywords[9].score | 0.07184833288192749 |
| keywords[9].display_name | Chemistry |
| language | en |
| locations[0].id | doi:10.1088/1758-5090/ad8b70 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S26035906 |
| locations[0].source.issn | 1758-5082, 1758-5090 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | 1758-5082 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Biofabrication |
| locations[0].source.host_organization | https://openalex.org/P4310320083 |
| locations[0].source.host_organization_name | IOP Publishing |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320083, https://openalex.org/P4310311669 |
| locations[0].source.host_organization_lineage_names | IOP Publishing, Institute of Physics |
| locations[0].license | cc-by |
| locations[0].pdf_url | |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Biofabrication |
| locations[0].landing_page_url | https://doi.org/10.1088/1758-5090/ad8b70 |
| locations[1].id | pmid:39454611 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Biofabrication |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/39454611 |
| locations[2].id | pmh:oai:cris.unibo.it:11585/1027300 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S4306402579 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) |
| locations[2].source.host_organization | https://openalex.org/I4210117483 |
| locations[2].source.host_organization_name | Istituto di Ematologia di Bologna |
| locations[2].source.host_organization_lineage | https://openalex.org/I4210117483 |
| locations[2].license | other-oa |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | info:eu-repo/semantics/article |
| locations[2].license_id | https://openalex.org/licenses/other-oa |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | |
| locations[2].landing_page_url | https://hdl.handle.net/11585/1027300 |
| indexed_in | crossref, pubmed |
| authorships[0].author.id | https://openalex.org/A5038702745 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-2000-7408 |
| authorships[0].author.display_name | Nihan Sengokmen-Ozsoz |
| authorships[0].countries | GB, TR |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I91136226 |
| authorships[0].affiliations[0].raw_affiliation_string | Kroto Research Institute, Department of Materials Science and Engineering, The University of Sheffield, Sheffield S3 7HQ, United Kingdom. |
| authorships[0].affiliations[1].institution_ids | https://openalex.org/I109297418 |
| authorships[0].affiliations[1].raw_affiliation_string | Department of Materials Science and Engineering, Gebze Technical University, Gebze, Kocaeli 41400, Turkey. |
| authorships[0].institutions[0].id | https://openalex.org/I91136226 |
| authorships[0].institutions[0].ror | https://ror.org/05krs5044 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I91136226 |
| authorships[0].institutions[0].country_code | GB |
| authorships[0].institutions[0].display_name | University of Sheffield |
| authorships[0].institutions[1].id | https://openalex.org/I109297418 |
| authorships[0].institutions[1].ror | https://ror.org/01sdnnq10 |
| authorships[0].institutions[1].type | education |
| authorships[0].institutions[1].lineage | https://openalex.org/I109297418 |
| authorships[0].institutions[1].country_code | TR |
| authorships[0].institutions[1].display_name | Gebze Technical University |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Nihan Sengokmen-Ozsoz |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Department of Materials Science and Engineering, Gebze Technical University, Gebze, Kocaeli 41400, Turkey., Kroto Research Institute, Department of Materials Science and Engineering, The University of Sheffield, Sheffield S3 7HQ, United Kingdom. |
| authorships[1].author.id | https://openalex.org/A5060866855 |
| authorships[1].author.orcid | https://orcid.org/0000-0001-8261-4046 |
| authorships[1].author.display_name | Mina Aleemardani |
| authorships[1].countries | GB |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I91136226 |
| authorships[1].affiliations[0].raw_affiliation_string | Kroto Research Institute, Department of Materials Science and Engineering, The University of Sheffield, Sheffield S3 7HQ, United Kingdom. |
| authorships[1].affiliations[1].institution_ids | https://openalex.org/I36234482 |
| authorships[1].affiliations[1].raw_affiliation_string | Department of Translational Health Science, Bristol Medical School, University of Bristol, Bristol BS1 3NY, United Kingdom. |
| authorships[1].institutions[0].id | https://openalex.org/I36234482 |
| authorships[1].institutions[0].ror | https://ror.org/0524sp257 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I36234482 |
| authorships[1].institutions[0].country_code | GB |
| authorships[1].institutions[0].display_name | University of Bristol |
| authorships[1].institutions[1].id | https://openalex.org/I91136226 |
| authorships[1].institutions[1].ror | https://ror.org/05krs5044 |
| authorships[1].institutions[1].type | education |
| authorships[1].institutions[1].lineage | https://openalex.org/I91136226 |
| authorships[1].institutions[1].country_code | GB |
| authorships[1].institutions[1].display_name | University of Sheffield |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Mina Aleemardani |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Translational Health Science, Bristol Medical School, University of Bristol, Bristol BS1 3NY, United Kingdom., Kroto Research Institute, Department of Materials Science and Engineering, The University of Sheffield, Sheffield S3 7HQ, United Kingdom. |
| authorships[2].author.id | https://openalex.org/A5011415066 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-1231-2728 |
| authorships[2].author.display_name | Marco Palanca |
| authorships[2].countries | GB, IT |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I4210147861, https://openalex.org/I91136226 |
| authorships[2].affiliations[0].raw_affiliation_string | INSIGNEO Institute for In Silico Medicine, The University of Sheffield, Sheffield, United Kingdom. |
| authorships[2].affiliations[1].institution_ids | https://openalex.org/I91136226 |
| authorships[2].affiliations[1].raw_affiliation_string | Department of Oncology and Metabolism, The University of Sheffield, Sheffield, United Kingdom. |
| authorships[2].affiliations[2].institution_ids | https://openalex.org/I9360294 |
| authorships[2].affiliations[2].raw_affiliation_string | Department of Industrial Engineering, Alma Mater Studiorum-University of Bologna, Bologna, Italy. |
| authorships[2].institutions[0].id | https://openalex.org/I4210147861 |
| authorships[2].institutions[0].ror | https://ror.org/04ve58z79 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I4210147861 |
| authorships[2].institutions[0].country_code | GB |
| authorships[2].institutions[0].display_name | Insigneo |
| authorships[2].institutions[1].id | https://openalex.org/I91136226 |
| authorships[2].institutions[1].ror | https://ror.org/05krs5044 |
| authorships[2].institutions[1].type | education |
| authorships[2].institutions[1].lineage | https://openalex.org/I91136226 |
| authorships[2].institutions[1].country_code | GB |
| authorships[2].institutions[1].display_name | University of Sheffield |
| authorships[2].institutions[2].id | https://openalex.org/I9360294 |
| authorships[2].institutions[2].ror | https://ror.org/01111rn36 |
| authorships[2].institutions[2].type | education |
| authorships[2].institutions[2].lineage | https://openalex.org/I9360294 |
| authorships[2].institutions[2].country_code | IT |
| authorships[2].institutions[2].display_name | University of Bologna |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Marco Palanca |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Industrial Engineering, Alma Mater Studiorum-University of Bologna, Bologna, Italy., Department of Oncology and Metabolism, The University of Sheffield, Sheffield, United Kingdom., INSIGNEO Institute for In Silico Medicine, The University of Sheffield, Sheffield, United Kingdom. |
| authorships[3].author.id | https://openalex.org/A5073154159 |
| authorships[3].author.orcid | |
| authorships[3].author.display_name | Alice Jane Hann |
| authorships[3].countries | GB |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I91136226 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Materials Science and Engineering, Pam Liversidge Building, Mappin Street, Sheffield, United Kingdom. |
| authorships[3].institutions[0].id | https://openalex.org/I91136226 |
| authorships[3].institutions[0].ror | https://ror.org/05krs5044 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I91136226 |
| authorships[3].institutions[0].country_code | GB |
| authorships[3].institutions[0].display_name | University of Sheffield |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Alice Hann |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Materials Science and Engineering, Pam Liversidge Building, Mappin Street, Sheffield, United Kingdom. |
| authorships[4].author.id | https://openalex.org/A5105979536 |
| authorships[4].author.orcid | https://orcid.org/0000-0003-1456-1071 |
| authorships[4].author.display_name | Gwendolen C. Reilly |
| authorships[4].countries | GB |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I91136226 |
| authorships[4].affiliations[0].raw_affiliation_string | Department of Materials Science and Engineering, Pam Liversidge Building, Mappin Street, Sheffield, United Kingdom. |
| authorships[4].institutions[0].id | https://openalex.org/I91136226 |
| authorships[4].institutions[0].ror | https://ror.org/05krs5044 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I91136226 |
| authorships[4].institutions[0].country_code | GB |
| authorships[4].institutions[0].display_name | University of Sheffield |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Gwendolen C Reilly |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Department of Materials Science and Engineering, Pam Liversidge Building, Mappin Street, Sheffield, United Kingdom. |
| authorships[5].author.id | https://openalex.org/A5090776949 |
| authorships[5].author.orcid | https://orcid.org/0000-0003-1471-5077 |
| authorships[5].author.display_name | Enrico Dall’Ara |
| authorships[5].countries | GB |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I4210147861, https://openalex.org/I91136226 |
| authorships[5].affiliations[0].raw_affiliation_string | INSIGNEO Institute for In Silico Medicine, The University of Sheffield, Sheffield, United Kingdom. |
| authorships[5].affiliations[1].institution_ids | https://openalex.org/I91136226 |
| authorships[5].affiliations[1].raw_affiliation_string | Department of Oncology and Metabolism, The University of Sheffield, Sheffield, United Kingdom. |
| authorships[5].institutions[0].id | https://openalex.org/I4210147861 |
| authorships[5].institutions[0].ror | https://ror.org/04ve58z79 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I4210147861 |
| authorships[5].institutions[0].country_code | GB |
| authorships[5].institutions[0].display_name | Insigneo |
| authorships[5].institutions[1].id | https://openalex.org/I91136226 |
| authorships[5].institutions[1].ror | https://ror.org/05krs5044 |
| authorships[5].institutions[1].type | education |
| authorships[5].institutions[1].lineage | https://openalex.org/I91136226 |
| authorships[5].institutions[1].country_code | GB |
| authorships[5].institutions[1].display_name | University of Sheffield |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Enrico Dall'Ara |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Department of Oncology and Metabolism, The University of Sheffield, Sheffield, United Kingdom., INSIGNEO Institute for In Silico Medicine, The University of Sheffield, Sheffield, United Kingdom. |
| authorships[6].author.id | https://openalex.org/A5087716394 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-1030-939X |
| authorships[6].author.display_name | Frederik Claeyssens |
| authorships[6].countries | GB |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I91136226 |
| authorships[6].affiliations[0].raw_affiliation_string | Kroto Research Institute, Department of Materials Science and Engineering, The University of Sheffield, Sheffield S3 7HQ, United Kingdom. |
| authorships[6].institutions[0].id | https://openalex.org/I91136226 |
| authorships[6].institutions[0].ror | https://ror.org/05krs5044 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I91136226 |
| authorships[6].institutions[0].country_code | GB |
| authorships[6].institutions[0].display_name | University of Sheffield |
| authorships[6].author_position | last |
| authorships[6].raw_author_name | Frederik Claeyssens |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Kroto Research Institute, Department of Materials Science and Engineering, The University of Sheffield, Sheffield S3 7HQ, United Kingdom. |
| has_content.pdf | False |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://doi.org/10.1088/1758-5090/ad8b70 |
| open_access.oa_status | hybrid |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Fabrication of hierarchically porous trabecular bone replicas via 3D printing with high internal phase emulsions (HIPEs) |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T11915 |
| primary_topic.field.id | https://openalex.org/fields/25 |
| primary_topic.field.display_name | Materials Science |
| primary_topic.score | 0.9997000098228455 |
| primary_topic.domain.id | https://openalex.org/domains/3 |
| primary_topic.domain.display_name | Physical Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2505 |
| primary_topic.subfield.display_name | Materials Chemistry |
| primary_topic.display_name | Pickering emulsions and particle stabilization |
| related_works | https://openalex.org/W2082914599, https://openalex.org/W2756570351, https://openalex.org/W2393554192, https://openalex.org/W2359463116, https://openalex.org/W2362875760, https://openalex.org/W392422591, https://openalex.org/W1968527418, https://openalex.org/W2392518446, https://openalex.org/W4312199566, https://openalex.org/W3004274744 |
| cited_by_count | 12 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 12 |
| locations_count | 3 |
| best_oa_location.id | doi:10.1088/1758-5090/ad8b70 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S26035906 |
| best_oa_location.source.issn | 1758-5082, 1758-5090 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | 1758-5082 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | Biofabrication |
| best_oa_location.source.host_organization | https://openalex.org/P4310320083 |
| best_oa_location.source.host_organization_name | IOP Publishing |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320083, https://openalex.org/P4310311669 |
| best_oa_location.source.host_organization_lineage_names | IOP Publishing, Institute of Physics |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Biofabrication |
| best_oa_location.landing_page_url | https://doi.org/10.1088/1758-5090/ad8b70 |
| primary_location.id | doi:10.1088/1758-5090/ad8b70 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S26035906 |
| primary_location.source.issn | 1758-5082, 1758-5090 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | 1758-5082 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Biofabrication |
| primary_location.source.host_organization | https://openalex.org/P4310320083 |
| primary_location.source.host_organization_name | IOP Publishing |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320083, https://openalex.org/P4310311669 |
| primary_location.source.host_organization_lineage_names | IOP Publishing, Institute of Physics |
| primary_location.license | cc-by |
| primary_location.pdf_url | |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Biofabrication |
| primary_location.landing_page_url | https://doi.org/10.1088/1758-5090/ad8b70 |
| publication_date | 2024-10-25 |
| publication_year | 2024 |
| referenced_works | https://openalex.org/W1954225767, https://openalex.org/W2504137427, https://openalex.org/W2343706545, https://openalex.org/W2944151023, https://openalex.org/W2969581489, https://openalex.org/W3008340222, https://openalex.org/W2074255287, https://openalex.org/W2074865082, https://openalex.org/W3158599238, https://openalex.org/W4294611838, https://openalex.org/W4387842458, https://openalex.org/W2045717301, https://openalex.org/W2810235521, https://openalex.org/W3048624891, https://openalex.org/W3164539139, https://openalex.org/W2031650452, https://openalex.org/W1993418575, https://openalex.org/W1502574692, https://openalex.org/W2019168090, https://openalex.org/W2470852637, https://openalex.org/W2904887897, https://openalex.org/W2922030314, https://openalex.org/W1902391461, https://openalex.org/W2089889928, https://openalex.org/W1493967000, https://openalex.org/W2563322415, https://openalex.org/W2321214840, https://openalex.org/W3021299273, https://openalex.org/W2701735813, https://openalex.org/W2046061689, https://openalex.org/W2592607234, https://openalex.org/W2425661062, https://openalex.org/W2108278446, https://openalex.org/W2617594473, https://openalex.org/W4319072244, https://openalex.org/W2032005070, https://openalex.org/W4380421937, https://openalex.org/W4288062131, https://openalex.org/W4387670529, https://openalex.org/W4313543657, https://openalex.org/W2009845905, https://openalex.org/W2897548725, https://openalex.org/W3005337730, https://openalex.org/W2588534180, https://openalex.org/W2474969214, https://openalex.org/W4391467325, https://openalex.org/W4365449642, https://openalex.org/W4398146495, https://openalex.org/W3021148647, https://openalex.org/W3042706343, https://openalex.org/W3136475771, https://openalex.org/W4306645417, https://openalex.org/W4379882757, https://openalex.org/W3011294891, https://openalex.org/W4378647098, https://openalex.org/W4327615260, https://openalex.org/W2027464255, https://openalex.org/W2969535285, https://openalex.org/W2611143088, https://openalex.org/W3033225111, https://openalex.org/W3022241261, https://openalex.org/W2050875646, https://openalex.org/W2046043107, https://openalex.org/W3004519387, https://openalex.org/W4385371513, https://openalex.org/W2411919892, https://openalex.org/W3210119451, https://openalex.org/W2085640464, https://openalex.org/W1976212754, https://openalex.org/W3058198167, https://openalex.org/W3195481135, https://openalex.org/W2095433422, https://openalex.org/W6737295520, https://openalex.org/W2802074542, https://openalex.org/W2771105938, https://openalex.org/W3176596103, https://openalex.org/W4315864649, https://openalex.org/W2074844604, https://openalex.org/W2066713881, https://openalex.org/W1992747950, https://openalex.org/W3057906274, https://openalex.org/W3037377977, https://openalex.org/W3013187652, https://openalex.org/W4376983038, https://openalex.org/W2610274718 |
| referenced_works_count | 85 |
| abstract_inverted_index.a | 24, 42, 51, 72, 97, 119, 221 |
| abstract_inverted_index.3D | 31 |
| abstract_inverted_index.60 | 207 |
| abstract_inverted_index.In | 80 |
| abstract_inverted_index.T) | 155 |
| abstract_inverted_index.To | 163 |
| abstract_inverted_index.as | 96, 220 |
| abstract_inverted_index.be | 174, 218, 233 |
| abstract_inverted_index.by | 203 |
| abstract_inverted_index.in | 60 |
| abstract_inverted_index.m. | 79 |
| abstract_inverted_index.of | 10, 55, 75, 88, 104, 118, 209, 239 |
| abstract_inverted_index.on | 134, 189 |
| abstract_inverted_index.to | 176, 223 |
| abstract_inverted_index.we | 83, 130, 183 |
| abstract_inverted_index.µ | 78 |
| abstract_inverted_index.(0, | 90 |
| abstract_inverted_index.150 | 77 |
| abstract_inverted_index.The | 148 |
| abstract_inverted_index.and | 39, 58, 71, 93, 121, 127, 146, 161, 200, 241 |
| abstract_inverted_index.can | 63, 173, 217 |
| abstract_inverted_index.for | 124, 180, 197, 236 |
| abstract_inverted_index.how | 85 |
| abstract_inverted_index.the | 8, 61, 101, 116, 157 |
| abstract_inverted_index.vat | 113 |
| abstract_inverted_index.via | 112 |
| abstract_inverted_index.wt% | 150 |
| abstract_inverted_index.(008 | 154 |
| abstract_inverted_index.0.08 | 94, 149 |
| abstract_inverted_index.This | 17, 212 |
| abstract_inverted_index.best | 158 |
| abstract_inverted_index.bone | 186, 226 |
| abstract_inverted_index.cell | 28, 132, 159, 198, 210 |
| abstract_inverted_index.days | 208 |
| abstract_inverted_index.disk | 137 |
| abstract_inverted_index.have | 47 |
| abstract_inverted_index.high | 167 |
| abstract_inverted_index.open | 65 |
| abstract_inverted_index.show | 164 |
| abstract_inverted_index.that | 26, 36, 49, 165, 215 |
| abstract_inverted_index.this | 81, 166 |
| abstract_inverted_index.used | 175, 219 |
| abstract_inverted_index.were | 194 |
| abstract_inverted_index.with | 4, 14 |
| abstract_inverted_index.wt%) | 95 |
| abstract_inverted_index.0.02, | 91 |
| abstract_inverted_index.0.04, | 92 |
| abstract_inverted_index.Given | 115 |
| abstract_inverted_index.HIPEs | 216 |
| abstract_inverted_index.MG-63 | 140 |
| abstract_inverted_index.These | 192 |
| abstract_inverted_index.about | 76 |
| abstract_inverted_index.after | 206 |
| abstract_inverted_index.based | 188 |
| abstract_inverted_index.bone. | 243 |
| abstract_inverted_index.could | 232 |
| abstract_inverted_index.light | 56, 98 |
| abstract_inverted_index.phase | 109, 169 |
| abstract_inverted_index.print | 224 |
| abstract_inverted_index.resin | 62, 172, 222 |
| abstract_inverted_index.task. | 44 |
| abstract_inverted_index.these | 135 |
| abstract_inverted_index.using | 50, 139, 228 |
| abstract_inverted_index.which | 231 |
| abstract_inverted_index.(HIPE) | 171 |
| abstract_inverted_index.affect | 100 |
| abstract_inverted_index.cells, | 141 |
| abstract_inverted_index.create | 177 |
| abstract_inverted_index.medium | 107 |
| abstract_inverted_index.mimics | 227 |
| abstract_inverted_index.models | 238 |
| abstract_inverted_index.porous | 12, 21, 34, 102, 120 |
| abstract_inverted_index.sample | 153 |
| abstract_inverted_index.study, | 82 |
| abstract_inverted_index.tested | 131 |
| abstract_inverted_index.tissue | 125 |
| abstract_inverted_index.combine | 37 |
| abstract_inverted_index.complex | 178 |
| abstract_inverted_index.enables | 7 |
| abstract_inverted_index.further | 195, 234 |
| abstract_inverted_index.healthy | 240 |
| abstract_inverted_index.microCT | 190, 204 |
| abstract_inverted_index.produce | 64 |
| abstract_inverted_index.remains | 41 |
| abstract_inverted_index.samples | 138 |
| abstract_inverted_index.studies | 46 |
| abstract_inverted_index.surface | 66 |
| abstract_inverted_index.varying | 86 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.However, | 30 |
| abstract_inverted_index.Previous | 45 |
| abstract_inverted_index.absorber | 99 |
| abstract_inverted_index.additive | 5, 229 |
| abstract_inverted_index.adjusted | 53 |
| abstract_inverted_index.analysis | 205 |
| abstract_inverted_index.approach | 18 |
| abstract_inverted_index.behavior | 133, 199 |
| abstract_inverted_index.culture. | 211 |
| abstract_inverted_index.diseased | 242 |
| abstract_inverted_index.emulsion | 2, 170 |
| abstract_inverted_index.explored | 84 |
| abstract_inverted_index.followed | 202 |
| abstract_inverted_index.imaging. | 191 |
| abstract_inverted_index.internal | 69, 108, 168 |
| abstract_inverted_index.printing | 32, 73 |
| abstract_inverted_index.research | 213 |
| abstract_inverted_index.supports | 27 |
| abstract_inverted_index.Combining | 1 |
| abstract_inverted_index.absorbers | 57 |
| abstract_inverted_index.activity, | 144 |
| abstract_inverted_index.adhesion, | 145 |
| abstract_inverted_index.adhesion. | 162 |
| abstract_inverted_index.carefully | 52 |
| abstract_inverted_index.developed | 235 |
| abstract_inverted_index.emulsions | 110 |
| abstract_inverted_index.evaluated | 196 |
| abstract_inverted_index.examining | 142 |
| abstract_inverted_index.ingrowth. | 29 |
| abstract_inverted_index.medicine, | 129 |
| abstract_inverted_index.metabolic | 143 |
| abstract_inverted_index.porosity, | 67 |
| abstract_inverted_index.porosity. | 16 |
| abstract_inverted_index.providing | 23 |
| abstract_inverted_index.scaffolds | 13 |
| abstract_inverted_index.structure | 25, 103, 123 |
| abstract_inverted_index.3D-printed | 136, 152, 184 |
| abstract_inverted_index.biomedical | 181 |
| abstract_inverted_index.fabricated | 111 |
| abstract_inverted_index.importance | 117 |
| abstract_inverted_index.inherently | 11 |
| abstract_inverted_index.materials, | 22 |
| abstract_inverted_index.micropores | 40 |
| abstract_inverted_index.migration, | 201 |
| abstract_inverted_index.multiscale | 15 |
| abstract_inverted_index.production | 9 |
| abstract_inverted_index.resolution | 74 |
| abstract_inverted_index.structures | 35, 179, 187, 193 |
| abstract_inverted_index.tartrazine | 89 |
| abstract_inverted_index.templating | 3 |
| abstract_inverted_index.trabecular | 185, 225 |
| abstract_inverted_index.challenging | 43 |
| abstract_inverted_index.combination | 54 |
| abstract_inverted_index.engineering | 126 |
| abstract_inverted_index.morphology. | 147 |
| abstract_inverted_index.polymerized | 106 |
| abstract_inverted_index.sponge-like | 68 |
| abstract_inverted_index.structures, | 70 |
| abstract_inverted_index.demonstrated | 48, 156 |
| abstract_inverted_index.demonstrates | 214 |
| abstract_inverted_index.hierarchical | 33 |
| abstract_inverted_index.incorporates | 19 |
| abstract_inverted_index.regenerative | 128 |
| abstract_inverted_index.applications, | 182 |
| abstract_inverted_index.lab-on-a-chip | 237 |
| abstract_inverted_index.manufacturing | 6 |
| abstract_inverted_index.proliferation | 160 |
| abstract_inverted_index.acrylate-based | 105 |
| abstract_inverted_index.concentrations | 87 |
| abstract_inverted_index.interconnected | 20, 122 |
| abstract_inverted_index.manufacturing, | 230 |
| abstract_inverted_index.photoinitiators | 59 |
| abstract_inverted_index.semi-micropores | 38 |
| abstract_inverted_index.photopolymerization. | 114 |
| abstract_inverted_index.tartrazine-containing | 151 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 98 |
| countries_distinct_count | 3 |
| institutions_distinct_count | 7 |
| citation_normalized_percentile.value | 0.89888494 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |