FAM172A deletion aggravates high fat diet-induced MASLD via the eIF2α-ATF4-FGF21 loop Article Swipe
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FGF21
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Herui Wei
,
Meixin Gao
,
Shiwei Wang
,
Junru Yang
,
Zhe Yu
,
Mengqi Li
,
Hongshan Wei
,
Fan Xiao
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1016/j.lfs.2025.123763
· OA: W4410720447
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1016/j.lfs.2025.123763
· OA: W4410720447
Fam172a gene deletion can promote HFD-induced MASLD via the eIF2α-ATF4 pathway. The expression of Fgf21, up-regulated by the eIF2α-ATF4 pathway, partially inhibit the effects of Fam172a gene deletion via negative feedback loop. Thus, FAM172A may serve as a potential target of MASLD.
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