Farnesol Improves Endoplasmic Reticulum Stress and Hepatic Metabolic Dysfunction Induced by Tunicamycin in Mice Article Swipe
Naqash Goswami
,
Lionel Kinkpe
,
Lun Hua
,
Yong Zhuo
,
Zhengfeng Fang
,
Lianqiang Che
,
Yan Lin
,
Shengyu Xu
,
Xuemei Jiang
,
Bin Feng
,
De Wu
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/biology14020213
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/biology14020213
Endoplasmic reticulum (ER) stress significantly affects liver metabolism, often leading to disorders such as hepatic steatosis. Tunicamycin (TM), a known ER stress inducer, is frequently used to model metabolic stress, but its specific effects on liver energy homeostasis remain unclear. This study investigates how farnesol (FOH), a natural compound with antioxidant and anti-inflammatory properties, counteracts TM-induced ER stress and its associated metabolic disruptions in the liver. Using both primary hepatocytes and a mouse model, this study demonstrates that TM treatment caused upregulation of ER stress markers, including ATF4, and disrupted genes related to lipid metabolism and gluconeogenesis. Co-treatment with FOH reduced these stress markers and restored the expression of metabolic genes. In vivo, FOH treatment alleviated oxidative stress, reduced lipid accumulation, and restored normal glycogen and lipid metabolism. Histological analysis further confirmed that FOH preserved liver architecture and minimized cellular damage. FOH also stabilized serum lipid profiles and modulated key metabolic biomarkers, suggesting its protective role against TM-induced liver injury. These findings suggest that FOH has therapeutic potential in mitigating ER stress-related metabolic dysfunctions, offering promising insights for the treatment of liver diseases linked to metabolic stress.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/biology14020213
- OA Status
- gold
- References
- 51
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4407675484
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Raw OpenAlex JSON
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https://openalex.org/W4407675484Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/biology14020213Digital Object Identifier
- Title
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Farnesol Improves Endoplasmic Reticulum Stress and Hepatic Metabolic Dysfunction Induced by Tunicamycin in MiceWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-02-18Full publication date if available
- Authors
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Naqash Goswami, Lionel Kinkpe, Lun Hua, Yong Zhuo, Zhengfeng Fang, Lianqiang Che, Yan Lin, Shengyu Xu, Xuemei Jiang, Bin Feng, De WuList of authors in order
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https://doi.org/10.3390/biology14020213Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.3390/biology14020213Direct OA link when available
- Concepts
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Endoplasmic reticulum, Unfolded protein response, Biology, Tunicamycin, Oxidative stress, Lipid metabolism, Endocrinology, Steatosis, Internal medicine, Downregulation and upregulation, Cell biology, Biochemistry, Medicine, GeneTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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