Fast Improvements of Acute Inflammatory Symptomatology in Patients With Hand Osteoarthritis With the Use of Doxycycline. Article Swipe
Mário Newton Leitão de Azevedo
,
Marco Antonio Cullar Arnez
,
Ingrid Bandeira Moss
,
Breno Valdetaro Bianchi
,
Blance Elena Rios Gomes Bica
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-3511645/v1
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-3511645/v1
Background: Osteoarthritis (OA) presents the high activity of free radicals and proteolytic enzymes which were inhibited by Doxycycline (DOX). Objective : To search the efficacy, safety, and fastness for the improvement of inflammatory signs in patients with Hand Osteoarthritis (HOA). Methodology: Randomized, placebo-controlled trial during four weeks with two groups of patients: DOX group using one tablet of 100 mg bid per os; control group using paracetamol bid per os ; the data were obtained through Visual Analog Scale (VAS) evaluation for pain, flushing/edema by the patient and the examiner; the primary outcome was the improvement greater than 50% from the basal values after four weeks . Results: Thirty-eight female patients with HOA after menopause were allocated: 20 in the DOX group and 18 in the control group. The results showed that the DOX group presented a significant improvement in 75% of patients compared to the control group (p <0.00000), which started after 6.05 ± 3.7 days of treatment; and mild adverse effects in 20% of the sample - gastric pain, nausea, vomiting after 9.0 ± 5.2 days without any removal from the trial. Compared to the baseline and the control group results, was observed a significant improvement in pain (p <0.00000) and edema/flushing (p<0.00000) demonstrated the efficacy of inflammation; no abnormality was seen on the blood analysis, and no hematological, renal, cardiologic and hepatic commitment. Conclusion: Doxycycline by a short length of time was safe and improved the pain and inflammatory signs of HOA.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.21203/rs.3.rs-3511645/v1
- https://www.researchsquare.com/article/rs-3511645/latest.pdf
- OA Status
- green
- References
- 24
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4388044461
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4388044461Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.21203/rs.3.rs-3511645/v1Digital Object Identifier
- Title
-
Fast Improvements of Acute Inflammatory Symptomatology in Patients With Hand Osteoarthritis With the Use of Doxycycline.Work title
- Type
-
preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2023Year of publication
- Publication date
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2023-10-31Full publication date if available
- Authors
-
Mário Newton Leitão de Azevedo, Marco Antonio Cullar Arnez, Ingrid Bandeira Moss, Breno Valdetaro Bianchi, Blance Elena Rios Gomes BicaList of authors in order
- Landing page
-
https://doi.org/10.21203/rs.3.rs-3511645/v1Publisher landing page
- PDF URL
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https://www.researchsquare.com/article/rs-3511645/latest.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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greenOpen access status per OpenAlex
- OA URL
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https://www.researchsquare.com/article/rs-3511645/latest.pdfDirect OA link when available
- Concepts
-
Medicine, Nausea, Osteoarthritis, Vomiting, Placebo, Edema, Randomized controlled trial, Visual analogue scale, Anesthesia, Adverse effect, Doxycycline, Surgery, Internal medicine, Gastroenterology, Antibiotics, Microbiology, Pathology, Alternative medicine, BiologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- References (count)
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24Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| publication_date | 2023-10-31 |
| publication_year | 2023 |
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