Fatigue and cognition: Pupillary responses to problem‐solving in early multiple sclerosis patients Article Swipe
Sigrid A. de Rodez Benavent
,
Gro Owren Nygaard
,
Hanne F. Harbo
,
Siren Tønnesen
,
Piotr Sowa
,
Nils Inge Landrø
,
Marte Wendel‐Haga
,
Lars Etholm
,
Kristian Bernhard Nilsen
,
Liv Drolsum
,
Emı́lia Kerty
,
Elisabeth Gulowsen Celius
,
Bruno Laeng
·
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1002/brb3.717
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1002/brb3.717
Introduction In early multiple sclerosis ( MS ) patients, cognitive changes and fatigue are frequent and troublesome symptoms, probably related to both structural and functional brain changes. Whether there is a common cause of these symptoms in MS is unknown. In theory, an altered regulation of central neuropeptides can lead to changes in regulation of autonomic function, cognitive difficulties, and fatigue. Direct measurements of central neuropeptides are difficult to perform, but measurements of the eye pupil can be used as a reliable proxy of function. Methods This study assesses pupil size during problem‐solving in early MS patients versus controls. A difference in pupil size to a cognitive challenge could signal altered activity within the autonomic system because of early functional brain changes associated with cognitive load. We recruited MS patients (mean disease duration: 2.6 years, N = 41) and age‐matched healthy controls ( N = 43) without eye pathology. Neurological impairment, magnetic resonance imaging, visual evoked potentials, depression, and fatigue were assessed in all of the patients. In both groups, we assessed processing speed and retinal imaging. Pupil size was recorded with an eye‐tracker during playback of multiplication tasks. Results Both groups performed well on the cognitive test. The groups showed similar pupillary responses with a mean of 0.55 mm dilation in patients and 0.54 mm dilation in controls for all the tasks collapsed together. However, controls ( N = 9) with low cognitive scores ( LCS ) had an increased pupillary response to cognitive tasks, whereas LCS MS patients ( N = 6) did not ( p < .05). There was a tendency toward a smaller pupillary response in patients with fatigue. Conclusions This is the first study to investigate pupillary responses to cognitive tasks in MS patients. Our results suggest that MS ‐related changes in cognition and fatigue may be associated with changes in arousal and the autonomic regulation of task‐related pupillary responses. This supports the theory of a link between cognition and fatigue in MS .
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/brb3.717
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/brb3.717
- OA Status
- gold
- Cited By
- 34
- References
- 60
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2616212186
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2616212186Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1002/brb3.717Digital Object Identifier
- Title
-
Fatigue and cognition: Pupillary responses to problem‐solving in early multiple sclerosis patientsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2017Year of publication
- Publication date
-
2017-05-17Full publication date if available
- Authors
-
Sigrid A. de Rodez Benavent, Gro Owren Nygaard, Hanne F. Harbo, Siren Tønnesen, Piotr Sowa, Nils Inge Landrø, Marte Wendel‐Haga, Lars Etholm, Kristian Bernhard Nilsen, Liv Drolsum, Emı́lia Kerty, Elisabeth Gulowsen Celius, Bruno LaengList of authors in order
- Landing page
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https://doi.org/10.1002/brb3.717Publisher landing page
- PDF URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/brb3.717Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/brb3.717Direct OA link when available
- Concepts
-
Pupillary response, Multiple sclerosis, Cognition, Psychology, Audiology, Medicine, Functional magnetic resonance imaging, Pupil, Neuroscience, Physical medicine and rehabilitation, Cardiology, Internal medicine, PsychiatryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
34Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 3, 2024: 3, 2023: 6, 2022: 2, 2021: 4Per-year citation counts (last 5 years)
- References (count)
-
60Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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