FBLN1 regulates ferroptosis in acute respiratory distress syndrome by reducing free ferrous iron by inhibiting the TGF-β/Smad pathway Article Swipe
Yaping Yuan
,
Youbo Wang
,
Yu-Feng Yan
,
Edward Kim
,
Jin Bai
,
Yang Zhao
,
Qinyun Ma
,
Wenchao Gu
,
Haihan Song
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1371/journal.pone.0314750
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1371/journal.pone.0314750
Background Acute respiratory distress syndrome (ARDS) / acute lung injury (ALI) is a serious medical disease characterized by pulmonary dysfunction and inflammation. This study aims to determine the main molecular modules linked to ARDS and investigate the role of Fibulin-1 (FBLN1) in regulating ferroptosis in ARDS. Methods Weighted Gene Co-expression Network Analysis (WGCNA) was employed on the GSE263867 dataset to find key modules associated with ALI. Differentially expressed genes (DEGs) and protein-protein interaction (PPI) networks were analyzed. MLE-12 cells were treated with lipopolysaccharide (LPS) to induce ferroptosis. In vitro studies were conducted to investigate the effects of FBLN1 and Transforming Growth Factor Beta 1 (TGF-β) overexpression on cell viability, oxidative stress markers, and ferroptosis-related proteins. Results WGCNA identified the turquoise module as significantly negatively correlated with ARDS. Five key overlapping genes ( GRIA1 , OGN , COL14A1 , FBLN1 , and COL6A3 ) were significantly downregulated in ARDS samples. LPS treatment induced ferroptosis in MLE-12 cells, indicated by increased malondialdehyde (MDA), lipid reactive oxygen species (ROS), and ferrous iron (Fe 2 ⁺) levels, and decreased cell viability and glutathione (GSH) levels. FBLN1 overexpression partially reversed these effects. Additionally, FBLN1 inhibited the TGF-β/Smad signaling pathway, as shown by decreased TGF-β and p-Smad protein levels. TGF-β overexpression exacerbated LPS-induced oxidative stress and ferroptosis, reducing cell viability and GSH levels. FBLN1 overexpression counteracted this effect, suggesting antagonistic roles for FBLN1 and TGF-β in regulating ferroptosis. Conclusion This study highlights FBLN1 as a critical regulator of ferroptosis in ARDS. Targeting the TGF-β/Smad pathway to modulate FBLN1 expression offers a potential therapeutic strategy to alleviate oxidative stress and mitigate pulmonary injury in inflammatory lung diseases.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1371/journal.pone.0314750
- https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0314750&type=printable
- OA Status
- gold
- Cited By
- 2
- References
- 36
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4405363387
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4405363387Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1371/journal.pone.0314750Digital Object Identifier
- Title
-
FBLN1 regulates ferroptosis in acute respiratory distress syndrome by reducing free ferrous iron by inhibiting the TGF-β/Smad pathwayWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-12-13Full publication date if available
- Authors
-
Yaping Yuan, Youbo Wang, Yu-Feng Yan, Edward Kim, Jin Bai, Yang Zhao, Qinyun Ma, Wenchao Gu, Haihan SongList of authors in order
- Landing page
-
https://doi.org/10.1371/journal.pone.0314750Publisher landing page
- PDF URL
-
https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0314750&type=printableDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0314750&type=printableDirect OA link when available
- Concepts
-
ARDS, SMAD, Oxidative stress, Viability assay, Transforming growth factor, Reactive oxygen species, Malondialdehyde, Biology, Cell biology, Cancer research, Cell, Immunology, Medicine, Internal medicine, Endocrinology, Lung, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
2Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2Per-year citation counts (last 5 years)
- References (count)
-
36Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4405363387 |
|---|---|
| doi | https://doi.org/10.1371/journal.pone.0314750 |
| ids.doi | https://doi.org/10.1371/journal.pone.0314750 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/39671383 |
| ids.openalex | https://openalex.org/W4405363387 |
| fwci | 1.72524628 |
| mesh[0].qualifier_ui | Q000235 |
| mesh[0].descriptor_ui | D000079403 |
| mesh[0].is_major_topic | True |
| mesh[0].qualifier_name | genetics |
| mesh[0].descriptor_name | Ferroptosis |
| mesh[1].qualifier_ui | Q000378 |
| mesh[1].descriptor_ui | D012128 |
| mesh[1].is_major_topic | True |
| mesh[1].qualifier_name | metabolism |
| mesh[1].descriptor_name | Respiratory Distress Syndrome |
| mesh[2].qualifier_ui | Q000235 |
| mesh[2].descriptor_ui | D012128 |
| mesh[2].is_major_topic | True |
| mesh[2].qualifier_name | genetics |
| mesh[2].descriptor_name | Respiratory Distress Syndrome |
| mesh[3].qualifier_ui | Q000473 |
| mesh[3].descriptor_ui | D012128 |
| mesh[3].is_major_topic | True |
| mesh[3].qualifier_name | pathology |
| mesh[3].descriptor_name | Respiratory Distress Syndrome |
| mesh[4].qualifier_ui | |
| mesh[4].descriptor_ui | D006801 |
| mesh[4].is_major_topic | False |
| mesh[4].qualifier_name | |
| mesh[4].descriptor_name | Humans |
| mesh[5].qualifier_ui | Q000378 |
| mesh[5].descriptor_ui | D051785 |
| mesh[5].is_major_topic | True |
| mesh[5].qualifier_name | metabolism |
| mesh[5].descriptor_name | Smad Proteins |
| mesh[6].qualifier_ui | |
| mesh[6].descriptor_ui | D015398 |
| mesh[6].is_major_topic | True |
| mesh[6].qualifier_name | |
| mesh[6].descriptor_name | Signal Transduction |
| mesh[7].qualifier_ui | Q000378 |
| mesh[7].descriptor_ui | D007501 |
| mesh[7].is_major_topic | True |
| mesh[7].qualifier_name | metabolism |
| mesh[7].descriptor_name | Iron |
| mesh[8].qualifier_ui | Q000378 |
| mesh[8].descriptor_ui | D016212 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | metabolism |
| mesh[8].descriptor_name | Transforming Growth Factor beta |
| mesh[9].qualifier_ui | |
| mesh[9].descriptor_ui | D018384 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | |
| mesh[9].descriptor_name | Oxidative Stress |
| mesh[10].qualifier_ui | |
| mesh[10].descriptor_ui | D008070 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | |
| mesh[10].descriptor_name | Lipopolysaccharides |
| mesh[11].qualifier_ui | |
| mesh[11].descriptor_ui | D002460 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | |
| mesh[11].descriptor_name | Cell Line |
| mesh[12].qualifier_ui | |
| mesh[12].descriptor_ui | D051379 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | |
| mesh[12].descriptor_name | Mice |
| mesh[13].qualifier_ui | Q000378 |
| mesh[13].descriptor_ui | D017382 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | metabolism |
| mesh[13].descriptor_name | Reactive Oxygen Species |
| mesh[14].qualifier_ui | |
| mesh[14].descriptor_ui | D000818 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | |
| mesh[14].descriptor_name | Animals |
| mesh[15].qualifier_ui | |
| mesh[15].descriptor_ui | D060066 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | |
| mesh[15].descriptor_name | Protein Interaction Maps |
| mesh[16].qualifier_ui | Q000187 |
| mesh[16].descriptor_ui | D002470 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | drug effects |
| mesh[16].descriptor_name | Cell Survival |
| mesh[17].qualifier_ui | Q000235 |
| mesh[17].descriptor_ui | D000079403 |
| mesh[17].is_major_topic | True |
| mesh[17].qualifier_name | genetics |
| mesh[17].descriptor_name | Ferroptosis |
| mesh[18].qualifier_ui | Q000378 |
| mesh[18].descriptor_ui | D012128 |
| mesh[18].is_major_topic | True |
| mesh[18].qualifier_name | metabolism |
| mesh[18].descriptor_name | Respiratory Distress Syndrome |
| mesh[19].qualifier_ui | Q000235 |
| mesh[19].descriptor_ui | D012128 |
| mesh[19].is_major_topic | True |
| mesh[19].qualifier_name | genetics |
| mesh[19].descriptor_name | Respiratory Distress Syndrome |
| mesh[20].qualifier_ui | Q000473 |
| mesh[20].descriptor_ui | D012128 |
| mesh[20].is_major_topic | True |
| mesh[20].qualifier_name | pathology |
| mesh[20].descriptor_name | Respiratory Distress Syndrome |
| mesh[21].qualifier_ui | |
| mesh[21].descriptor_ui | D006801 |
| mesh[21].is_major_topic | False |
| mesh[21].qualifier_name | |
| mesh[21].descriptor_name | Humans |
| mesh[22].qualifier_ui | Q000378 |
| mesh[22].descriptor_ui | D051785 |
| mesh[22].is_major_topic | True |
| mesh[22].qualifier_name | metabolism |
| mesh[22].descriptor_name | Smad Proteins |
| mesh[23].qualifier_ui | |
| mesh[23].descriptor_ui | D015398 |
| mesh[23].is_major_topic | True |
| mesh[23].qualifier_name | |
| mesh[23].descriptor_name | Signal Transduction |
| mesh[24].qualifier_ui | Q000378 |
| mesh[24].descriptor_ui | D007501 |
| mesh[24].is_major_topic | True |
| mesh[24].qualifier_name | metabolism |
| mesh[24].descriptor_name | Iron |
| mesh[25].qualifier_ui | Q000378 |
| mesh[25].descriptor_ui | D016212 |
| mesh[25].is_major_topic | False |
| mesh[25].qualifier_name | metabolism |
| mesh[25].descriptor_name | Transforming Growth Factor beta |
| mesh[26].qualifier_ui | |
| mesh[26].descriptor_ui | D018384 |
| mesh[26].is_major_topic | False |
| mesh[26].qualifier_name | |
| mesh[26].descriptor_name | Oxidative Stress |
| mesh[27].qualifier_ui | |
| mesh[27].descriptor_ui | D008070 |
| mesh[27].is_major_topic | False |
| mesh[27].qualifier_name | |
| mesh[27].descriptor_name | Lipopolysaccharides |
| mesh[28].qualifier_ui | |
| mesh[28].descriptor_ui | D002460 |
| mesh[28].is_major_topic | False |
| mesh[28].qualifier_name | |
| mesh[28].descriptor_name | Cell Line |
| mesh[29].qualifier_ui | |
| mesh[29].descriptor_ui | D051379 |
| mesh[29].is_major_topic | False |
| mesh[29].qualifier_name | |
| mesh[29].descriptor_name | Mice |
| mesh[30].qualifier_ui | Q000378 |
| mesh[30].descriptor_ui | D017382 |
| mesh[30].is_major_topic | False |
| mesh[30].qualifier_name | metabolism |
| mesh[30].descriptor_name | Reactive Oxygen Species |
| mesh[31].qualifier_ui | |
| mesh[31].descriptor_ui | D000818 |
| mesh[31].is_major_topic | False |
| mesh[31].qualifier_name | |
| mesh[31].descriptor_name | Animals |
| mesh[32].qualifier_ui | |
| mesh[32].descriptor_ui | D060066 |
| mesh[32].is_major_topic | False |
| mesh[32].qualifier_name | |
| mesh[32].descriptor_name | Protein Interaction Maps |
| mesh[33].qualifier_ui | Q000187 |
| mesh[33].descriptor_ui | D002470 |
| mesh[33].is_major_topic | False |
| mesh[33].qualifier_name | drug effects |
| mesh[33].descriptor_name | Cell Survival |
| mesh[34].qualifier_ui | Q000235 |
| mesh[34].descriptor_ui | D000079403 |
| mesh[34].is_major_topic | True |
| mesh[34].qualifier_name | genetics |
| mesh[34].descriptor_name | Ferroptosis |
| mesh[35].qualifier_ui | Q000378 |
| mesh[35].descriptor_ui | D012128 |
| mesh[35].is_major_topic | True |
| mesh[35].qualifier_name | metabolism |
| mesh[35].descriptor_name | Respiratory Distress Syndrome |
| mesh[36].qualifier_ui | Q000235 |
| mesh[36].descriptor_ui | D012128 |
| mesh[36].is_major_topic | True |
| mesh[36].qualifier_name | genetics |
| mesh[36].descriptor_name | Respiratory Distress Syndrome |
| mesh[37].qualifier_ui | Q000473 |
| mesh[37].descriptor_ui | D012128 |
| mesh[37].is_major_topic | True |
| mesh[37].qualifier_name | pathology |
| mesh[37].descriptor_name | Respiratory Distress Syndrome |
| mesh[38].qualifier_ui | |
| mesh[38].descriptor_ui | D006801 |
| mesh[38].is_major_topic | False |
| mesh[38].qualifier_name | |
| mesh[38].descriptor_name | Humans |
| mesh[39].qualifier_ui | Q000378 |
| mesh[39].descriptor_ui | D051785 |
| mesh[39].is_major_topic | True |
| mesh[39].qualifier_name | metabolism |
| mesh[39].descriptor_name | Smad Proteins |
| mesh[40].qualifier_ui | |
| mesh[40].descriptor_ui | D015398 |
| mesh[40].is_major_topic | True |
| mesh[40].qualifier_name | |
| mesh[40].descriptor_name | Signal Transduction |
| mesh[41].qualifier_ui | Q000378 |
| mesh[41].descriptor_ui | D007501 |
| mesh[41].is_major_topic | True |
| mesh[41].qualifier_name | metabolism |
| mesh[41].descriptor_name | Iron |
| mesh[42].qualifier_ui | Q000378 |
| mesh[42].descriptor_ui | D016212 |
| mesh[42].is_major_topic | False |
| mesh[42].qualifier_name | metabolism |
| mesh[42].descriptor_name | Transforming Growth Factor beta |
| mesh[43].qualifier_ui | |
| mesh[43].descriptor_ui | D018384 |
| mesh[43].is_major_topic | False |
| mesh[43].qualifier_name | |
| mesh[43].descriptor_name | Oxidative Stress |
| mesh[44].qualifier_ui | |
| mesh[44].descriptor_ui | D008070 |
| mesh[44].is_major_topic | False |
| mesh[44].qualifier_name | |
| mesh[44].descriptor_name | Lipopolysaccharides |
| mesh[45].qualifier_ui | |
| mesh[45].descriptor_ui | D002460 |
| mesh[45].is_major_topic | False |
| mesh[45].qualifier_name | |
| mesh[45].descriptor_name | Cell Line |
| mesh[46].qualifier_ui | |
| mesh[46].descriptor_ui | D051379 |
| mesh[46].is_major_topic | False |
| mesh[46].qualifier_name | |
| mesh[46].descriptor_name | Mice |
| mesh[47].qualifier_ui | Q000378 |
| mesh[47].descriptor_ui | D017382 |
| mesh[47].is_major_topic | False |
| mesh[47].qualifier_name | metabolism |
| mesh[47].descriptor_name | Reactive Oxygen Species |
| mesh[48].qualifier_ui | |
| mesh[48].descriptor_ui | D000818 |
| mesh[48].is_major_topic | False |
| mesh[48].qualifier_name | |
| mesh[48].descriptor_name | Animals |
| mesh[49].qualifier_ui | |
| mesh[49].descriptor_ui | D060066 |
| mesh[49].is_major_topic | False |
| mesh[49].qualifier_name | |
| mesh[49].descriptor_name | Protein Interaction Maps |
| type | article |
| title | FBLN1 regulates ferroptosis in acute respiratory distress syndrome by reducing free ferrous iron by inhibiting the TGF-β/Smad pathway |
| biblio.issue | 12 |
| biblio.volume | 19 |
| biblio.last_page | e0314750 |
| biblio.first_page | e0314750 |
| topics[0].id | https://openalex.org/T11297 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9993000030517578 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2740 |
| topics[0].subfield.display_name | Pulmonary and Respiratory Medicine |
| topics[0].display_name | Ferroptosis and cancer prognosis |
| topics[1].id | https://openalex.org/T10515 |
| topics[1].field.id | https://openalex.org/fields/13 |
| topics[1].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[1].score | 0.9950000047683716 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1306 |
| topics[1].subfield.display_name | Cancer Research |
| topics[1].display_name | Cancer-related molecular mechanisms research |
| topics[2].id | https://openalex.org/T10269 |
| topics[2].field.id | https://openalex.org/fields/13 |
| topics[2].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[2].score | 0.9944000244140625 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/1312 |
| topics[2].subfield.display_name | Molecular Biology |
| topics[2].display_name | Epigenetics and DNA Methylation |
| is_xpac | False |
| apc_list.value | 1805 |
| apc_list.currency | USD |
| apc_list.value_usd | 1805 |
| apc_paid.value | 1805 |
| apc_paid.currency | USD |
| apc_paid.value_usd | 1805 |
| concepts[0].id | https://openalex.org/C2776348555 |
| concepts[0].level | 3 |
| concepts[0].score | 0.8323270678520203 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q344873 |
| concepts[0].display_name | ARDS |
| concepts[1].id | https://openalex.org/C2781080636 |
| concepts[1].level | 3 |
| concepts[1].score | 0.626377522945404 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q700000 |
| concepts[1].display_name | SMAD |
| concepts[2].id | https://openalex.org/C2776151105 |
| concepts[2].level | 2 |
| concepts[2].score | 0.5982003211975098 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q898814 |
| concepts[2].display_name | Oxidative stress |
| concepts[3].id | https://openalex.org/C53227056 |
| concepts[3].level | 3 |
| concepts[3].score | 0.574627161026001 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q189152 |
| concepts[3].display_name | Viability assay |
| concepts[4].id | https://openalex.org/C118131993 |
| concepts[4].level | 2 |
| concepts[4].score | 0.5404037833213806 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q423671 |
| concepts[4].display_name | Transforming growth factor |
| concepts[5].id | https://openalex.org/C48349386 |
| concepts[5].level | 2 |
| concepts[5].score | 0.5093463659286499 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q424361 |
| concepts[5].display_name | Reactive oxygen species |
| concepts[6].id | https://openalex.org/C2778401633 |
| concepts[6].level | 3 |
| concepts[6].score | 0.4766343832015991 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q418661 |
| concepts[6].display_name | Malondialdehyde |
| concepts[7].id | https://openalex.org/C86803240 |
| concepts[7].level | 0 |
| concepts[7].score | 0.4080883264541626 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[7].display_name | Biology |
| concepts[8].id | https://openalex.org/C95444343 |
| concepts[8].level | 1 |
| concepts[8].score | 0.3990253806114197 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q7141 |
| concepts[8].display_name | Cell biology |
| concepts[9].id | https://openalex.org/C502942594 |
| concepts[9].level | 1 |
| concepts[9].score | 0.3745190501213074 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q3421914 |
| concepts[9].display_name | Cancer research |
| concepts[10].id | https://openalex.org/C1491633281 |
| concepts[10].level | 2 |
| concepts[10].score | 0.3365243673324585 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q7868 |
| concepts[10].display_name | Cell |
| concepts[11].id | https://openalex.org/C203014093 |
| concepts[11].level | 1 |
| concepts[11].score | 0.3278893828392029 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q101929 |
| concepts[11].display_name | Immunology |
| concepts[12].id | https://openalex.org/C71924100 |
| concepts[12].level | 0 |
| concepts[12].score | 0.3221341371536255 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[12].display_name | Medicine |
| concepts[13].id | https://openalex.org/C126322002 |
| concepts[13].level | 1 |
| concepts[13].score | 0.21747222542762756 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[13].display_name | Internal medicine |
| concepts[14].id | https://openalex.org/C134018914 |
| concepts[14].level | 1 |
| concepts[14].score | 0.17753496766090393 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q162606 |
| concepts[14].display_name | Endocrinology |
| concepts[15].id | https://openalex.org/C2777714996 |
| concepts[15].level | 2 |
| concepts[15].score | 0.1474376618862152 |
| concepts[15].wikidata | https://www.wikidata.org/wiki/Q7886 |
| concepts[15].display_name | Lung |
| concepts[16].id | https://openalex.org/C55493867 |
| concepts[16].level | 1 |
| concepts[16].score | 0.11250776052474976 |
| concepts[16].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[16].display_name | Biochemistry |
| keywords[0].id | https://openalex.org/keywords/ards |
| keywords[0].score | 0.8323270678520203 |
| keywords[0].display_name | ARDS |
| keywords[1].id | https://openalex.org/keywords/smad |
| keywords[1].score | 0.626377522945404 |
| keywords[1].display_name | SMAD |
| keywords[2].id | https://openalex.org/keywords/oxidative-stress |
| keywords[2].score | 0.5982003211975098 |
| keywords[2].display_name | Oxidative stress |
| keywords[3].id | https://openalex.org/keywords/viability-assay |
| keywords[3].score | 0.574627161026001 |
| keywords[3].display_name | Viability assay |
| keywords[4].id | https://openalex.org/keywords/transforming-growth-factor |
| keywords[4].score | 0.5404037833213806 |
| keywords[4].display_name | Transforming growth factor |
| keywords[5].id | https://openalex.org/keywords/reactive-oxygen-species |
| keywords[5].score | 0.5093463659286499 |
| keywords[5].display_name | Reactive oxygen species |
| keywords[6].id | https://openalex.org/keywords/malondialdehyde |
| keywords[6].score | 0.4766343832015991 |
| keywords[6].display_name | Malondialdehyde |
| keywords[7].id | https://openalex.org/keywords/biology |
| keywords[7].score | 0.4080883264541626 |
| keywords[7].display_name | Biology |
| keywords[8].id | https://openalex.org/keywords/cell-biology |
| keywords[8].score | 0.3990253806114197 |
| keywords[8].display_name | Cell biology |
| keywords[9].id | https://openalex.org/keywords/cancer-research |
| keywords[9].score | 0.3745190501213074 |
| keywords[9].display_name | Cancer research |
| keywords[10].id | https://openalex.org/keywords/cell |
| keywords[10].score | 0.3365243673324585 |
| keywords[10].display_name | Cell |
| keywords[11].id | https://openalex.org/keywords/immunology |
| keywords[11].score | 0.3278893828392029 |
| keywords[11].display_name | Immunology |
| keywords[12].id | https://openalex.org/keywords/medicine |
| keywords[12].score | 0.3221341371536255 |
| keywords[12].display_name | Medicine |
| keywords[13].id | https://openalex.org/keywords/internal-medicine |
| keywords[13].score | 0.21747222542762756 |
| keywords[13].display_name | Internal medicine |
| keywords[14].id | https://openalex.org/keywords/endocrinology |
| keywords[14].score | 0.17753496766090393 |
| keywords[14].display_name | Endocrinology |
| keywords[15].id | https://openalex.org/keywords/lung |
| keywords[15].score | 0.1474376618862152 |
| keywords[15].display_name | Lung |
| keywords[16].id | https://openalex.org/keywords/biochemistry |
| keywords[16].score | 0.11250776052474976 |
| keywords[16].display_name | Biochemistry |
| language | en |
| locations[0].id | doi:10.1371/journal.pone.0314750 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S202381698 |
| locations[0].source.issn | 1932-6203 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 1932-6203 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | PLoS ONE |
| locations[0].source.host_organization | https://openalex.org/P4310315706 |
| locations[0].source.host_organization_name | Public Library of Science |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310315706 |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0314750&type=printable |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | PLOS ONE |
| locations[0].landing_page_url | https://doi.org/10.1371/journal.pone.0314750 |
| locations[1].id | pmid:39671383 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | PloS one |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/39671383 |
| locations[2].id | pmh:oai:pubmedcentral.nih.gov:11643259 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S2764455111 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed Central |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | other-oa |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | https://openalex.org/licenses/other-oa |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | PLoS One |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/11643259 |
| locations[3].id | pmh:oai:doaj.org/article:383369c6b11141b182b1c0e0be2f3a40 |
| locations[3].is_oa | False |
| locations[3].source.id | https://openalex.org/S4306401280 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[3].source.host_organization | |
| locations[3].source.host_organization_name | |
| locations[3].source.host_organization_lineage | |
| locations[3].license | |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | article |
| locations[3].license_id | |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | PLoS ONE, Vol 19, Iss 12, p e0314750 (2024) |
| locations[3].landing_page_url | https://doaj.org/article/383369c6b11141b182b1c0e0be2f3a40 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5105760420 |
| authorships[0].author.orcid | https://orcid.org/0009-0004-8737-1396 |
| authorships[0].author.display_name | Yaping Yuan |
| authorships[0].countries | CN |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I4210163796 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Pulmonary and Critical Care Medicine, Shanghai Pudong New Area People's Hospital, Shanghai, China |
| authorships[0].institutions[0].id | https://openalex.org/I4210163796 |
| authorships[0].institutions[0].ror | https://ror.org/02hx18343 |
| authorships[0].institutions[0].type | healthcare |
| authorships[0].institutions[0].lineage | https://openalex.org/I4210163796 |
| authorships[0].institutions[0].country_code | CN |
| authorships[0].institutions[0].display_name | Pudong New Area People's Hospital |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Yaping Yuan |
| authorships[0].is_corresponding | True |
| authorships[0].raw_affiliation_strings | Department of Pulmonary and Critical Care Medicine, Shanghai Pudong New Area People's Hospital, Shanghai, China |
| authorships[1].author.id | https://openalex.org/A5108846836 |
| authorships[1].author.orcid | |
| authorships[1].author.display_name | Youbo Wang |
| authorships[1].countries | CN |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I24943067, https://openalex.org/I4210159575 |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Thoracic Surgery, Huashan Hospital, Fudan University, Shanghai, China |
| authorships[1].institutions[0].id | https://openalex.org/I24943067 |
| authorships[1].institutions[0].ror | https://ror.org/013q1eq08 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I24943067 |
| authorships[1].institutions[0].country_code | CN |
| authorships[1].institutions[0].display_name | Fudan University |
| authorships[1].institutions[1].id | https://openalex.org/I4210159575 |
| authorships[1].institutions[1].ror | https://ror.org/05201qm87 |
| authorships[1].institutions[1].type | healthcare |
| authorships[1].institutions[1].lineage | https://openalex.org/I4210159575 |
| authorships[1].institutions[1].country_code | CN |
| authorships[1].institutions[1].display_name | Huashan Hospital |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Youbo Wang |
| authorships[1].is_corresponding | True |
| authorships[1].raw_affiliation_strings | Department of Thoracic Surgery, Huashan Hospital, Fudan University, Shanghai, China |
| authorships[2].author.id | https://openalex.org/A5019774483 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-8468-4002 |
| authorships[2].author.display_name | Yu-Feng Yan |
| authorships[2].countries | CN |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I4210099941 |
| authorships[2].affiliations[0].raw_affiliation_string | Department of Neurosurgery, Jinshan Hospital, Fudan University, Zhujing Town, Jinshan District, Shanghai, China |
| authorships[2].institutions[0].id | https://openalex.org/I4210099941 |
| authorships[2].institutions[0].ror | https://ror.org/013a5fa56 |
| authorships[2].institutions[0].type | healthcare |
| authorships[2].institutions[0].lineage | https://openalex.org/I4210099941 |
| authorships[2].institutions[0].country_code | CN |
| authorships[2].institutions[0].display_name | Jinshan Hospital of Fudan University |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Yufeng Yan |
| authorships[2].is_corresponding | True |
| authorships[2].raw_affiliation_strings | Department of Neurosurgery, Jinshan Hospital, Fudan University, Zhujing Town, Jinshan District, Shanghai, China |
| authorships[3].author.id | https://openalex.org/A5100728167 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-8660-7465 |
| authorships[3].author.display_name | Edward Kim |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Immunology, DICAT National Biomedical Computation Centre, Vancouver, BC, Canada |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Edward Kim |
| authorships[3].is_corresponding | True |
| authorships[3].raw_affiliation_strings | Department of Immunology, DICAT National Biomedical Computation Centre, Vancouver, BC, Canada |
| authorships[4].author.id | https://openalex.org/A5102297136 |
| authorships[4].author.orcid | |
| authorships[4].author.display_name | Jin Bai |
| authorships[4].affiliations[0].raw_affiliation_string | CRT Medical Union, Time International, Beijing, China |
| authorships[4].affiliations[1].raw_affiliation_string | Department of Immunology, DICAT National Biomedical Computation Centre, Vancouver, BC, Canada |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Jin Bai |
| authorships[4].is_corresponding | True |
| authorships[4].raw_affiliation_strings | CRT Medical Union, Time International, Beijing, China, Department of Immunology, DICAT National Biomedical Computation Centre, Vancouver, BC, Canada |
| authorships[5].author.id | https://openalex.org/A5015735546 |
| authorships[5].author.orcid | https://orcid.org/0000-0001-8814-7004 |
| authorships[5].author.display_name | Yang Zhao |
| authorships[5].affiliations[0].raw_affiliation_string | CRT Medical Union, Time International, Beijing, China |
| authorships[5].affiliations[1].raw_affiliation_string | Department of Immunology, DICAT National Biomedical Computation Centre, Vancouver, BC, Canada |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Yang Zhao |
| authorships[5].is_corresponding | True |
| authorships[5].raw_affiliation_strings | CRT Medical Union, Time International, Beijing, China, Department of Immunology, DICAT National Biomedical Computation Centre, Vancouver, BC, Canada |
| authorships[6].author.id | https://openalex.org/A5068702768 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-0867-2114 |
| authorships[6].author.display_name | Qinyun Ma |
| authorships[6].countries | CN |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I24943067, https://openalex.org/I4210159575 |
| authorships[6].affiliations[0].raw_affiliation_string | Department of Thoracic Surgery, Huashan Hospital, Fudan University, Shanghai, China |
| authorships[6].institutions[0].id | https://openalex.org/I24943067 |
| authorships[6].institutions[0].ror | https://ror.org/013q1eq08 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I24943067 |
| authorships[6].institutions[0].country_code | CN |
| authorships[6].institutions[0].display_name | Fudan University |
| authorships[6].institutions[1].id | https://openalex.org/I4210159575 |
| authorships[6].institutions[1].ror | https://ror.org/05201qm87 |
| authorships[6].institutions[1].type | healthcare |
| authorships[6].institutions[1].lineage | https://openalex.org/I4210159575 |
| authorships[6].institutions[1].country_code | CN |
| authorships[6].institutions[1].display_name | Huashan Hospital |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Qinyun Ma |
| authorships[6].is_corresponding | True |
| authorships[6].raw_affiliation_strings | Department of Thoracic Surgery, Huashan Hospital, Fudan University, Shanghai, China |
| authorships[7].author.id | https://openalex.org/A5035492444 |
| authorships[7].author.orcid | https://orcid.org/0000-0002-1505-9887 |
| authorships[7].author.display_name | Wenchao Gu |
| authorships[7].countries | CN |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I4210163796 |
| authorships[7].affiliations[0].raw_affiliation_string | Department of Pulmonary and Critical Care Medicine, Shanghai Pudong New Area People's Hospital, Shanghai, China |
| authorships[7].institutions[0].id | https://openalex.org/I4210163796 |
| authorships[7].institutions[0].ror | https://ror.org/02hx18343 |
| authorships[7].institutions[0].type | healthcare |
| authorships[7].institutions[0].lineage | https://openalex.org/I4210163796 |
| authorships[7].institutions[0].country_code | CN |
| authorships[7].institutions[0].display_name | Pudong New Area People's Hospital |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Wenchao Gu |
| authorships[7].is_corresponding | True |
| authorships[7].raw_affiliation_strings | Department of Pulmonary and Critical Care Medicine, Shanghai Pudong New Area People's Hospital, Shanghai, China |
| authorships[8].author.id | https://openalex.org/A5103230285 |
| authorships[8].author.orcid | https://orcid.org/0009-0006-7753-8628 |
| authorships[8].author.display_name | Haihan Song |
| authorships[8].countries | CN |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I4210163796 |
| authorships[8].affiliations[0].raw_affiliation_string | Department of Pulmonary and Critical Care Medicine, Shanghai Pudong New Area People's Hospital, Shanghai, China |
| authorships[8].affiliations[1].institution_ids | https://openalex.org/I4210163796 |
| authorships[8].affiliations[1].raw_affiliation_string | Central Lab, Shanghai Key Laboratory of Pathogenic Fungi Medical Testing, Shanghai Pudong New Area People's Hospital, Shanghai, China |
| authorships[8].affiliations[2].raw_affiliation_string | Department of Immunology, DICAT National Biomedical Computation Centre, Vancouver, BC, Canada |
| authorships[8].institutions[0].id | https://openalex.org/I4210163796 |
| authorships[8].institutions[0].ror | https://ror.org/02hx18343 |
| authorships[8].institutions[0].type | healthcare |
| authorships[8].institutions[0].lineage | https://openalex.org/I4210163796 |
| authorships[8].institutions[0].country_code | CN |
| authorships[8].institutions[0].display_name | Pudong New Area People's Hospital |
| authorships[8].author_position | last |
| authorships[8].raw_author_name | Haihan Song |
| authorships[8].is_corresponding | True |
| authorships[8].raw_affiliation_strings | Central Lab, Shanghai Key Laboratory of Pathogenic Fungi Medical Testing, Shanghai Pudong New Area People's Hospital, Shanghai, China, Department of Immunology, DICAT National Biomedical Computation Centre, Vancouver, BC, Canada, Department of Pulmonary and Critical Care Medicine, Shanghai Pudong New Area People's Hospital, Shanghai, China |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0314750&type=printable |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | FBLN1 regulates ferroptosis in acute respiratory distress syndrome by reducing free ferrous iron by inhibiting the TGF-β/Smad pathway |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T11297 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9993000030517578 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2740 |
| primary_topic.subfield.display_name | Pulmonary and Respiratory Medicine |
| primary_topic.display_name | Ferroptosis and cancer prognosis |
| related_works | https://openalex.org/W4253170077, https://openalex.org/W4389790735, https://openalex.org/W1670324689, https://openalex.org/W3030570121, https://openalex.org/W2077418945, https://openalex.org/W2776389664, https://openalex.org/W4387931142, https://openalex.org/W2377457626, https://openalex.org/W2544156601, https://openalex.org/W2384352427 |
| cited_by_count | 2 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 2 |
| locations_count | 4 |
| best_oa_location.id | doi:10.1371/journal.pone.0314750 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S202381698 |
| best_oa_location.source.issn | 1932-6203 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 1932-6203 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | PLoS ONE |
| best_oa_location.source.host_organization | https://openalex.org/P4310315706 |
| best_oa_location.source.host_organization_name | Public Library of Science |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310315706 |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0314750&type=printable |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | PLOS ONE |
| best_oa_location.landing_page_url | https://doi.org/10.1371/journal.pone.0314750 |
| primary_location.id | doi:10.1371/journal.pone.0314750 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S202381698 |
| primary_location.source.issn | 1932-6203 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 1932-6203 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | PLoS ONE |
| primary_location.source.host_organization | https://openalex.org/P4310315706 |
| primary_location.source.host_organization_name | Public Library of Science |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310315706 |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0314750&type=printable |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | PLOS ONE |
| primary_location.landing_page_url | https://doi.org/10.1371/journal.pone.0314750 |
| publication_date | 2024-12-13 |
| publication_year | 2024 |
| referenced_works | https://openalex.org/W4294535438, https://openalex.org/W6790402602, https://openalex.org/W3009291243, https://openalex.org/W4307368708, https://openalex.org/W2999859051, https://openalex.org/W3005037351, https://openalex.org/W3041366450, https://openalex.org/W2963945351, https://openalex.org/W3149914279, https://openalex.org/W4210704361, https://openalex.org/W4213128374, https://openalex.org/W2439973029, https://openalex.org/W2751285788, https://openalex.org/W4205463066, https://openalex.org/W3047329562, https://openalex.org/W3025725236, https://openalex.org/W3210722846, https://openalex.org/W3088186467, https://openalex.org/W4220838378, https://openalex.org/W4224234386, https://openalex.org/W4380871481, https://openalex.org/W4321495943, https://openalex.org/W4385266667, https://openalex.org/W2765665406, https://openalex.org/W4304689364, https://openalex.org/W3003960907, https://openalex.org/W3059762212, https://openalex.org/W3190181852, https://openalex.org/W4377140458, https://openalex.org/W4392286438, https://openalex.org/W3183476852, https://openalex.org/W4220834749, https://openalex.org/W3131363062, https://openalex.org/W4327596040, https://openalex.org/W3155293385, https://openalex.org/W3125587469 |
| referenced_works_count | 36 |
| abstract_inverted_index.( | 131 |
| abstract_inverted_index.) | 142 |
| abstract_inverted_index., | 133, 135, 137, 139 |
| abstract_inverted_index./ | 6 |
| abstract_inverted_index.1 | 103 |
| abstract_inverted_index.2 | 170 |
| abstract_inverted_index.a | 12, 238, 254 |
| abstract_inverted_index.In | 87 |
| abstract_inverted_index.as | 121, 194, 237 |
| abstract_inverted_index.by | 17, 157, 196 |
| abstract_inverted_index.in | 41, 44, 146, 153, 229, 243, 266 |
| abstract_inverted_index.is | 11 |
| abstract_inverted_index.of | 38, 96, 241 |
| abstract_inverted_index.on | 55, 106 |
| abstract_inverted_index.to | 25, 32, 59, 84, 92, 249, 258 |
| abstract_inverted_index.(Fe | 169 |
| abstract_inverted_index.GSH | 215 |
| abstract_inverted_index.LPS | 149 |
| abstract_inverted_index.OGN | 134 |
| abstract_inverted_index.and | 20, 34, 70, 98, 112, 140, 166, 173, 177, 199, 209, 214, 227, 262 |
| abstract_inverted_index.for | 225 |
| abstract_inverted_index.key | 61, 128 |
| abstract_inverted_index.the | 27, 36, 56, 94, 118, 190, 246 |
| abstract_inverted_index.was | 53 |
| abstract_inverted_index.ALI. | 65 |
| abstract_inverted_index.ARDS | 33, 147 |
| abstract_inverted_index.Beta | 102 |
| abstract_inverted_index.Five | 127 |
| abstract_inverted_index.Gene | 48 |
| abstract_inverted_index.This | 22, 233 |
| abstract_inverted_index.aims | 24 |
| abstract_inverted_index.cell | 107, 175, 212 |
| abstract_inverted_index.find | 60 |
| abstract_inverted_index.iron | 168 |
| abstract_inverted_index.lung | 8, 268 |
| abstract_inverted_index.main | 28 |
| abstract_inverted_index.role | 37 |
| abstract_inverted_index.this | 220 |
| abstract_inverted_index.were | 75, 79, 90, 143 |
| abstract_inverted_index.with | 64, 81, 125 |
| abstract_inverted_index.⁺) | 171 |
| abstract_inverted_index.(ALI) | 10 |
| abstract_inverted_index.(GSH) | 179 |
| abstract_inverted_index.(LPS) | 83 |
| abstract_inverted_index.(PPI) | 73 |
| abstract_inverted_index.ARDS. | 45, 126, 244 |
| abstract_inverted_index.Acute | 1 |
| abstract_inverted_index.FBLN1 | 97, 138, 181, 188, 217, 226, 236, 251 |
| abstract_inverted_index.GRIA1 | 132 |
| abstract_inverted_index.WGCNA | 116 |
| abstract_inverted_index.acute | 7 |
| abstract_inverted_index.cells | 78 |
| abstract_inverted_index.genes | 68, 130 |
| abstract_inverted_index.lipid | 161 |
| abstract_inverted_index.roles | 224 |
| abstract_inverted_index.shown | 195 |
| abstract_inverted_index.study | 23, 234 |
| abstract_inverted_index.these | 185 |
| abstract_inverted_index.vitro | 88 |
| abstract_inverted_index.(ARDS) | 5 |
| abstract_inverted_index.(DEGs) | 69 |
| abstract_inverted_index.(MDA), | 160 |
| abstract_inverted_index.(ROS), | 165 |
| abstract_inverted_index.COL6A3 | 141 |
| abstract_inverted_index.Factor | 101 |
| abstract_inverted_index.Growth | 100 |
| abstract_inverted_index.MLE-12 | 77, 154 |
| abstract_inverted_index.TGF-β | 198, 203, 228 |
| abstract_inverted_index.cells, | 155 |
| abstract_inverted_index.induce | 85 |
| abstract_inverted_index.injury | 9, 265 |
| abstract_inverted_index.linked | 31 |
| abstract_inverted_index.module | 120 |
| abstract_inverted_index.offers | 253 |
| abstract_inverted_index.oxygen | 163 |
| abstract_inverted_index.p-Smad | 200 |
| abstract_inverted_index.stress | 110, 208, 261 |
| abstract_inverted_index.(FBLN1) | 40 |
| abstract_inverted_index.(WGCNA) | 52 |
| abstract_inverted_index.COL14A1 | 136 |
| abstract_inverted_index.Methods | 46 |
| abstract_inverted_index.Network | 50 |
| abstract_inverted_index.Results | 115 |
| abstract_inverted_index.dataset | 58 |
| abstract_inverted_index.disease | 15 |
| abstract_inverted_index.effect, | 221 |
| abstract_inverted_index.effects | 95 |
| abstract_inverted_index.ferrous | 167 |
| abstract_inverted_index.induced | 151 |
| abstract_inverted_index.levels, | 172 |
| abstract_inverted_index.levels. | 180, 202, 216 |
| abstract_inverted_index.medical | 14 |
| abstract_inverted_index.modules | 30, 62 |
| abstract_inverted_index.pathway | 248 |
| abstract_inverted_index.protein | 201 |
| abstract_inverted_index.serious | 13 |
| abstract_inverted_index.species | 164 |
| abstract_inverted_index.studies | 89 |
| abstract_inverted_index.treated | 80 |
| abstract_inverted_index.(TGF-β) | 104 |
| abstract_inverted_index.Analysis | 51 |
| abstract_inverted_index.Weighted | 47 |
| abstract_inverted_index.critical | 239 |
| abstract_inverted_index.distress | 3 |
| abstract_inverted_index.effects. | 186 |
| abstract_inverted_index.employed | 54 |
| abstract_inverted_index.markers, | 111 |
| abstract_inverted_index.mitigate | 263 |
| abstract_inverted_index.modulate | 250 |
| abstract_inverted_index.networks | 74 |
| abstract_inverted_index.pathway, | 193 |
| abstract_inverted_index.reactive | 162 |
| abstract_inverted_index.reducing | 211 |
| abstract_inverted_index.reversed | 184 |
| abstract_inverted_index.samples. | 148 |
| abstract_inverted_index.strategy | 257 |
| abstract_inverted_index.syndrome | 4 |
| abstract_inverted_index.Fibulin-1 | 39 |
| abstract_inverted_index.GSE263867 | 57 |
| abstract_inverted_index.Targeting | 245 |
| abstract_inverted_index.alleviate | 259 |
| abstract_inverted_index.analyzed. | 76 |
| abstract_inverted_index.conducted | 91 |
| abstract_inverted_index.decreased | 174, 197 |
| abstract_inverted_index.determine | 26 |
| abstract_inverted_index.diseases. | 269 |
| abstract_inverted_index.expressed | 67 |
| abstract_inverted_index.increased | 158 |
| abstract_inverted_index.indicated | 156 |
| abstract_inverted_index.inhibited | 189 |
| abstract_inverted_index.molecular | 29 |
| abstract_inverted_index.oxidative | 109, 207, 260 |
| abstract_inverted_index.partially | 183 |
| abstract_inverted_index.potential | 255 |
| abstract_inverted_index.proteins. | 114 |
| abstract_inverted_index.pulmonary | 18, 264 |
| abstract_inverted_index.regulator | 240 |
| abstract_inverted_index.signaling | 192 |
| abstract_inverted_index.treatment | 150 |
| abstract_inverted_index.turquoise | 119 |
| abstract_inverted_index.viability | 176, 213 |
| abstract_inverted_index.Background | 0 |
| abstract_inverted_index.Conclusion | 232 |
| abstract_inverted_index.associated | 63 |
| abstract_inverted_index.correlated | 124 |
| abstract_inverted_index.expression | 252 |
| abstract_inverted_index.highlights | 235 |
| abstract_inverted_index.identified | 117 |
| abstract_inverted_index.negatively | 123 |
| abstract_inverted_index.regulating | 42, 230 |
| abstract_inverted_index.suggesting | 222 |
| abstract_inverted_index.viability, | 108 |
| abstract_inverted_index.LPS-induced | 206 |
| abstract_inverted_index.TGF-β/Smad | 191, 247 |
| abstract_inverted_index.dysfunction | 19 |
| abstract_inverted_index.exacerbated | 205 |
| abstract_inverted_index.ferroptosis | 43, 152, 242 |
| abstract_inverted_index.glutathione | 178 |
| abstract_inverted_index.interaction | 72 |
| abstract_inverted_index.investigate | 35, 93 |
| abstract_inverted_index.overlapping | 129 |
| abstract_inverted_index.respiratory | 2 |
| abstract_inverted_index.therapeutic | 256 |
| abstract_inverted_index.Transforming | 99 |
| abstract_inverted_index.antagonistic | 223 |
| abstract_inverted_index.counteracted | 219 |
| abstract_inverted_index.ferroptosis, | 210 |
| abstract_inverted_index.ferroptosis. | 86, 231 |
| abstract_inverted_index.inflammatory | 267 |
| abstract_inverted_index.Additionally, | 187 |
| abstract_inverted_index.Co-expression | 49 |
| abstract_inverted_index.characterized | 16 |
| abstract_inverted_index.downregulated | 145 |
| abstract_inverted_index.inflammation. | 21 |
| abstract_inverted_index.significantly | 122, 144 |
| abstract_inverted_index.Differentially | 66 |
| abstract_inverted_index.overexpression | 105, 182, 204, 218 |
| abstract_inverted_index.malondialdehyde | 159 |
| abstract_inverted_index.protein-protein | 71 |
| abstract_inverted_index.lipopolysaccharide | 82 |
| abstract_inverted_index.ferroptosis-related | 113 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 95 |
| corresponding_author_ids | https://openalex.org/A5019774483, https://openalex.org/A5108846836, https://openalex.org/A5068702768, https://openalex.org/A5102297136, https://openalex.org/A5100728167, https://openalex.org/A5103230285, https://openalex.org/A5035492444, https://openalex.org/A5015735546, https://openalex.org/A5105760420 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 9 |
| corresponding_institution_ids | https://openalex.org/I24943067, https://openalex.org/I4210099941, https://openalex.org/I4210159575, https://openalex.org/I4210163796 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.5600000023841858 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.82404947 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |