FBXW7 inhibits the progression of ESCC by directly inhibiting the stemness of tumor cells Article Swipe

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Yanghui Bi , Yanfang Yang , Yong Zhang , Caixia Cheng , Peisen Tang , Heng Xiao , Fajia Yuan , Weiwei Wu , Bin Yang ·

YOU? · · 2023 · Open Access · · DOI: https://doi.org/10.4149/neo_2023_230104n8

F-box and WD repeat domain containing 7 (FBXW7) is an aboriginal and high-frequency mutant gene associated with esophageal squamous cell carcinoma (ESCC). This study was designed to determine the clinical value and molecular mechanisms of FBXW7 in the development of ESCC. The clinical significance of FBXW7 was analyzed in ESCC from TCGA data. The effects of FBXW7 on proliferation, colony formation, migration and invasion, angiogenesis, and apoptosis were tested in ESCC cells. PCR-array, sphere formation assay, and quantitative real-time polymerase chain reaction (qPCR) were used to explore the mechanism of FBXW7. FBXW7 was a significantly mutated gene in ESCC. It was an independent and potential predictor for survival in ESCC patients. In addition, FBXW7 overexpression significantly inhibited ESCC cell proliferation, migration, invasion, angiogenesis, and promoted cell apoptosis. PCR array revealed that FBXW7 overexpression leads to a significant change of gene expressions associated with angiogenesis, cell senescence, and DNA damage and repair. Sphere formation assay and qPCR showed FBXW7 was associated with ESCC stem cell formation. Our results suggest that FBXW7 may act as a tumor suppressor by repressing cancer stem cell formation and regulating tumor angiogenesis, cell senescence, DNA damage, and repair in ESCC.

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Angiogenesis Cancer research Cell growth Biology Apoptosis Cell Senescence Stem cell Molecular biology Cell biology Genetics

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Type: article
Language: en
Landing Page: https://doi.org/10.4149/neo_2023_230104n8
PDF: http://www.elis.sk/download_file.php?product_id=8201&session_id=3qei8316dis1sj0051p8jb4td0
OA Status: hybrid
Cited By: 2
References: 56
Related Works: 10
OpenAlex ID: https://openalex.org/W4389087728

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OpenAlex ID: https://openalex.org/W4389087728

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DOI: https://doi.org/10.4149/neo_2023_230104n8

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Title: FBXW7 inhibits the progression of ESCC by directly inhibiting the stemness of tumor cells

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Type: article

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Language: en

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Publication year: 2023

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Publication date: 2023-11-28

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Authors: Yanghui Bi, Yanfang Yang, Yong Zhang, Caixia Cheng, Peisen Tang, Heng Xiao, Fajia Yuan, Weiwei Wu, Bin Yang

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Landing page: https://doi.org/10.4149/neo_2023_230104n8

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PDF URL: https://www.elis.sk/download_file.php?product_id=8201&session_id=3qei8316dis1sj0051p8jb4td0

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Concepts: Angiogenesis, Cancer research, Cell growth, Biology, Apoptosis, Cell, Senescence, Stem cell, Molecular biology, Cell biology, Genetics

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Cited by: 2

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