Feasibility, Implementation and Early Adoption of an Omega-3 Test-and-Treat Program to Reduce Preterm Birth Article Swipe
Karen Best
,
Celine Northcott
,
Lucy Simmonds
,
Philippa Middleton
,
Lisa N Yelland
,
Vanessa Moffa
,
Khoa Lam
,
Penelope Coates
,
Cornelia Späth
,
Carol Wai-Kwan Siu
,
Karen Glover
,
R. H. Smith
,
Robert A. Gibson
,
Maria Makrides
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1101/2025.06.12.25329455
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1101/2025.06.12.25329455
Objective To evaluate the feasibility and early adoption of the Omega-3 Test-and-Treat Program, a targeted intervention to reduce preterm birth in women with low omega-3 levels, implemented within routine antenatal care. Design A prospective implementation study using the Quality Enhancement Research Initiative (QUERI) framework, conducted between April 19, 2021, and June 30, 2022. Setting Antenatal care settings in South Australia, leveraging the South Australia (SA) Pathology, South Australian Serum Antenatal Screening (SAMSAS) program. Participants Pregnant women with singleton pregnancies 20 weeks’ and 58 (1.2%) from multiple pregnancies. Conclusion Early evaluations show the Omega-3 Test-and-Treat Program is feasible and integrates effectively into routine antenatal care. This real-world approach demonstrates strong potential to reduce preterm birth rates through targeted nutritional intervention, supporting its scalability and broader implementation. SUMMARY BOX The known: Preterm birth is a leading cause of infant morbidity and mortality. Omega-3 supplementation reduces preterm birth risk in women with low omega-3 levels, yet no standardised protocol exists for identifying and treating omega-3 levels during pregnancy. The new: The Omega-3 Test and Treat Program is feasible, integrates effectively into routine antenatal care, and has broad reach, with maternal characteristics of tested women consistent with those not tested. The implications: This scalable program has the potential to reduce preterm birth rates. Strong early adoption, high fidelity, and community engagement highlight its potential for broader implementation.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2025.06.12.25329455
- https://www.medrxiv.org/content/medrxiv/early/2025/06/13/2025.06.12.25329455.full.pdf
- OA Status
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- References
- 35
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4411268175
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4411268175Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2025.06.12.25329455Digital Object Identifier
- Title
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Feasibility, Implementation and Early Adoption of an Omega-3 Test-and-Treat Program to Reduce Preterm BirthWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-06-13Full publication date if available
- Authors
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Karen Best, Celine Northcott, Lucy Simmonds, Philippa Middleton, Lisa N Yelland, Vanessa Moffa, Khoa Lam, Penelope Coates, Cornelia Späth, Carol Wai-Kwan Siu, Karen Glover, R. H. Smith, Robert A. Gibson, Maria MakridesList of authors in order
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https://doi.org/10.1101/2025.06.12.25329455Publisher landing page
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https://www.medrxiv.org/content/medrxiv/early/2025/06/13/2025.06.12.25329455.full.pdfDirect link to full text PDF
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YesWhether a free full text is available
- OA status
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greenOpen access status per OpenAlex
- OA URL
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https://www.medrxiv.org/content/medrxiv/early/2025/06/13/2025.06.12.25329455.full.pdfDirect OA link when available
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Omega, Test (biology), Medicine, Computer science, Philosophy, Biology, Linguistics, PaleontologyTop concepts (fields/topics) attached by OpenAlex
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.provide | 111 |
| abstract_inverted_index.reduces | 290 |
| abstract_inverted_index.routine | 29, 249, 326 |
| abstract_inverted_index.samples | 204, 224 |
| abstract_inverted_index.strong, | 219 |
| abstract_inverted_index.tested. | 179, 343 |
| abstract_inverted_index.testing | 216 |
| abstract_inverted_index.through | 263 |
| abstract_inverted_index.(SAMSAS) | 72 |
| abstract_inverted_index.ABSTRACT | 0 |
| abstract_inverted_index.Measures | 124 |
| abstract_inverted_index.Pregnant | 75 |
| abstract_inverted_index.Program, | 13 |
| abstract_inverted_index.Research | 41 |
| abstract_inverted_index.adopters | 133 |
| abstract_inverted_index.adoption | 8 |
| abstract_inverted_index.analysed | 208 |
| abstract_inverted_index.approach | 254 |
| abstract_inverted_index.compared | 134 |
| abstract_inverted_index.criteria | 142, 217 |
| abstract_inverted_index.evaluate | 3 |
| abstract_inverted_index.feasible | 244 |
| abstract_inverted_index.fidelity | 197 |
| abstract_inverted_index.guidance | 114 |
| abstract_inverted_index.identify | 101 |
| abstract_inverted_index.maternal | 334 |
| abstract_inverted_index.multiple | 233 |
| abstract_inverted_index.ordering | 91 |
| abstract_inverted_index.program. | 73 |
| abstract_inverted_index.protocol | 303 |
| abstract_inverted_index.reported | 160 |
| abstract_inverted_index.scalable | 347 |
| abstract_inverted_index.settings | 57 |
| abstract_inverted_index.standard | 211 |
| abstract_inverted_index.targeted | 15, 264 |
| abstract_inverted_index.testing. | 95 |
| abstract_inverted_index.treating | 308 |
| abstract_inverted_index.weeks’ | 81, 146, 228 |
| abstract_inverted_index.Adherence | 214 |
| abstract_inverted_index.Antenatal | 55, 70 |
| abstract_inverted_index.Australia | 64 |
| abstract_inverted_index.Objective | 1 |
| abstract_inverted_index.Screening | 71 |
| abstract_inverted_index.adherence | 139 |
| abstract_inverted_index.adopters, | 182 |
| abstract_inverted_index.adoption, | 359 |
| abstract_inverted_index.antenatal | 30, 84, 250, 327 |
| abstract_inverted_index.community | 363 |
| abstract_inverted_index.conducted | 45 |
| abstract_inverted_index.feasible, | 322 |
| abstract_inverted_index.fidelity, | 361 |
| abstract_inverted_index.gestation | 82 |
| abstract_inverted_index.highlight | 365 |
| abstract_inverted_index.moderate, | 189 |
| abstract_inverted_index.morbidity | 285 |
| abstract_inverted_index.potential | 257, 351, 367 |
| abstract_inverted_index.pregnancy | 109 |
| abstract_inverted_index.providers | 88 |
| abstract_inverted_index.screening | 85 |
| abstract_inverted_index.singleton | 78 |
| abstract_inverted_index.(singleton | 143 |
| abstract_inverted_index.Australia, | 60 |
| abstract_inverted_index.Australian | 68 |
| abstract_inverted_index.Conclusion | 235 |
| abstract_inverted_index.Initiative | 42 |
| abstract_inverted_index.Pathology, | 66, 163 |
| abstract_inverted_index.clinically | 174 |
| abstract_inverted_index.comparable | 175 |
| abstract_inverted_index.consistent | 165, 339 |
| abstract_inverted_index.engagement | 364 |
| abstract_inverted_index.fidelity), | 129 |
| abstract_inverted_index.framework, | 44 |
| abstract_inverted_index.healthcare | 87 |
| abstract_inverted_index.integrates | 246, 323 |
| abstract_inverted_index.leveraging | 61 |
| abstract_inverted_index.mortality. | 287 |
| abstract_inverted_index.pregnancy. | 312 |
| abstract_inverted_index.real-world | 253 |
| abstract_inverted_index.structured | 98 |
| abstract_inverted_index.sufficient | 193 |
| abstract_inverted_index.supporting | 267 |
| abstract_inverted_index.timeframe. | 213 |
| abstract_inverted_index.undergoing | 83 |
| abstract_inverted_index.Enhancement | 40 |
| abstract_inverted_index.effectively | 247, 324 |
| abstract_inverted_index.evaluations | 237 |
| abstract_inverted_index.feasibility | 5, 126 |
| abstract_inverted_index.gestation), | 147 |
| abstract_inverted_index.identifying | 306 |
| abstract_inverted_index.implemented | 27 |
| abstract_inverted_index.nutritional | 265 |
| abstract_inverted_index.population, | 138 |
| abstract_inverted_index.pregnancies | 79, 144, 226 |
| abstract_inverted_index.prospective | 34 |
| abstract_inverted_index.responsible | 89 |
| abstract_inverted_index.scalability | 269 |
| abstract_inverted_index.Intervention | 96 |
| abstract_inverted_index.Participants | 74 |
| abstract_inverted_index.demonstrates | 255 |
| abstract_inverted_index.facilitating | 93 |
| abstract_inverted_index.intervention | 16 |
| abstract_inverted_index.pregnancies. | 234 |
| abstract_inverted_index.standardised | 302 |
| abstract_inverted_index.distribution. | 151 |
| abstract_inverted_index.implications: | 345 |
| abstract_inverted_index.intervention, | 266 |
| abstract_inverted_index.Test-and-Treat | 12, 241 |
| abstract_inverted_index.evidence-based | 112 |
| abstract_inverted_index.implementation | 35 |
| abstract_inverted_index.characteristics | 335 |
| abstract_inverted_index.demographically | 172 |
| abstract_inverted_index.implementation. | 272, 370 |
| abstract_inverted_index.supplementation | 113, 289 |
| abstract_inverted_index.representativeness | 130 |
| cited_by_percentile_year | |
| corresponding_author_ids | https://openalex.org/A5073901691 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 14 |
| corresponding_institution_ids | https://openalex.org/I4210137740, https://openalex.org/I5681781 |
| citation_normalized_percentile.value | 0.34671616 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |